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Sleep Disorders in Children pp 281–304Cite as

Disorders Associated with Increased Sleepiness

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Abstract

Sleepiness presents as increased likelihood of falling asleep during the day; however, in young children, behavioral problems such as irritability and impulsiveness can prevail. Consequence of excessive daytime sleepiness includes cognitive impairment accompanied by inattentiveness, academic difficulties, and mood changes. The most frequent causes of increased sleepiness are insufficient nocturnal sleep in obstructive sleep apnea, periodic leg movements, and restless legs syndrome (RLS). Alteration of circadian rhythms, predominantly sleep delay associated with chronic sleep loss, has a substantial role in increased daytime sleepiness in adolescence. The main topics of this chapter are disorders connected with central hypersomnolence. Narcolepsy type 1 is characterized by excessive daytime sleepiness and signs of REM-sleep dissociation, the most specific of which is cataplexy. It is connected with hypocretin deficiency in the cerebrospinal fluid. Narcolepsy type 2 has no cataplexy, and hypocretin level is usually normal. Childhood narcolepsy, particularly in young children, has some specific features. Sleep attacks may last several hours, and cataplexy may affect mainly muscles of the face. Idiopathic hypersomnia occurs rather rarely and starts usually in adolescence similarly to narcolepsy. Nocturnal sleep may be excessively long with difficult waking up and long-lasting daily naps. Multiple sleep latency test without sleep-onset REM periods (SOREMs) differentiates this disease from narcolepsy. Kleine-Levin syndrome is characterized by relapsing-remitting episodes of severe hypersomnolence, usually in association with cognitive, psychiatric, and behavioral disturbances. Secondary hypersomnolence includes cases due to medical disorders, such as brain injury, genetic disorders, and brain tumors, or due to psychiatric disorder or medication and other substance abuses.

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References

  1. Stores G, Montgomery P, Wiggs L. The psychosocial problems of children with narcolepsy and those with excessive daytime sleepiness of uncertain origin. Pediatrics. 2006;118:1116–23.

    Article  Google Scholar 

  2. Walters AS, Silvestri R, Zucconi M, et al. Review of the possible relationship and hypothetical links between attention deficit hyperactivity disorder (ADHD) and simple sleep related movement disorders, parasomnias, hypersomnias and circadian rhythm disorders. J Clin Sleep Med. 2008;4:591–600.

    PubMed  PubMed Central  Google Scholar 

  3. American Academy of Sleep Medicine. International classification of sleep disorders-ICSD, 3rd ed. Westchester: American Academy of Sleep Medicine; 2014.

    Google Scholar 

  4. Kotagal S. Hypersomnia in children: interface with psychiatric disorders. Child Adolesc Psychiatr Clin N Am. 2009;18:967–77.

    Article  PubMed  Google Scholar 

  5. Kothare SV, Kaleyias J. The clinical and laboratory assessment of the sleepy child. Semin Pediatr Neurol. 2008;15:61–9.

    Article  PubMed  Google Scholar 

  6. Saarenpaa OS, Laippala P, Koivikko M. Subjective sleepiness in children. Fam Pract. 2000;17:129–33.

    Article  Google Scholar 

  7. Gaina A, Sekine M, Hamanishi S, et al. Daytime sleepiness and associated factors in Japanese school children. J Pediatr. 2007;151:518–22.

    Article  PubMed  Google Scholar 

  8. Gibson ES, Powles AC, Thabane I, et al. Sleepiness is serious in adolescence: two surveys of 3235 Canadian students. BMC Public Health. 2006;6:116.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kothare SV, Kaleyias J. Sleepiness in children. In: Thorpy MJ, Billiard M, editors. Sleepiness: causes, consequences and treatment. Cambridge: Cambridge University; 2011;262–76.

    Google Scholar 

  10. Hirshkowitz M, Whiton K, Albert SM, et al. National sleep foundation´s sleep time duration recommendations: methodology and results summary. Sleep Health. 2015;1:40–3.

    Article  Google Scholar 

  11. Kohyma J. A newly proposed disease condition produced by light exposure during night: asynchronization. Brain Dev. 2009;31:255–73.

    Article  Google Scholar 

  12. Gradisar M, Gardner G, Dohnt H. Recent worldwide sleep patterns and problems during adolescence: a review and meta-analysis of age, region, and sleep. Sleep Med. 2011;12:110–8.

    Article  PubMed  Google Scholar 

  13. O’Brien LM. The neurocognitive effects of sleep disruption in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2009;18:813–23.

    Article  PubMed  Google Scholar 

  14. Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, et al. Learning, attention/hyperactivity, and conduct problems as sequelae of excessive daytime sleepiness in a general population study of young children. Sleep. 2012;35:627–32.

    Google Scholar 

  15. Perez-Chada D, Perez-Lloret S, Videla AJ, et al. Sleep disordered breathing and daytime sleepiness are associated with poor academic performance in teenagers. A study using the Pediatric Daytime Sleepiness Scale (PDSS). Sleep. 2007;30:1698–703.

    Google Scholar 

  16. Nevsimalova S. The diagnosis and treatment of pediatric narcolepsy. Cur Neurol Neurosci Rep. 2014;14:469–78.

    Article  Google Scholar 

  17. Silber MH, Krahn LE, Olson E, Pankratz VS. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep. 2002;25:197–202.

    PubMed  Google Scholar 

  18. Longstreth Jr WT, Koepsell TD, Ton TG, et al. The epidemiology of narcolepsy. Sleep. 2007;30:13–26.

    PubMed  Google Scholar 

  19. Nevsimalova S, Buskova J, Kemlink D, et al. Does age at the onset of narcolepsy influence the course and severity of the disease? Sleep Med. 2009;10:967–72.

    Article  PubMed  Google Scholar 

  20. Guilleminault C, Pelayo R. Narcolepsy in prepubertal children. Ann Neurol. 1998;43:135–42.

    Article  CAS  PubMed  Google Scholar 

  21. Serra L, Montagna P, Mignot E, et al. Cataplexy features in childhood narcolepsy. Mov Dis. 2008;23:858–65.

    Article  Google Scholar 

  22. Einen MA, Aran A, Mignot E, Nishino S. Pre-versus post-pubertal narcolepsy in children. Sleep. 2009;32(Suppl):A249–50.

    Google Scholar 

  23. Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, et al. Post-H1NH1 narcolepsy-cataplexy. Sleep. 2010;33:1428–30.

    PubMed  PubMed Central  Google Scholar 

  24. Han F, Lin L, Warby SC, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol. 2011;70:410–7.

    Article  PubMed  Google Scholar 

  25. Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS One. 2012;7:e33723.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Nohynek H, Jokinen J, Partinen M, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One. 2012;7:e33536.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Szakács A, Darin N, Hallböök T. Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination. Neurology. 2013;80:1315–21.

    Article  PubMed  Google Scholar 

  28. Heier MS, Gautvik KM, Wannag E, et al. Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A. Sleep Med. 2013;14:867–71.

    Article  CAS  PubMed  Google Scholar 

  29. Nevsimalova S. Childhood narcolepsy and H1N1 vaccination: stirring up a sleeping menance? Sleep Med. 2014;15:159–60.

    Article  PubMed  Google Scholar 

  30. Nevsimalova S, Jara C, Prihodova I, et al. Clinical features of childhood narcolepsy. Can cataplexy be foretold? Eur J Paed Neuro. 2011;15:320–5.

    Article  Google Scholar 

  31. Vendrame M, Havaligi N, Matedeen-Ali C, et al. Narcolepsy in children: a single-center clinical experience. Pediatr Neurol. 2008;38:314–20.

    Article  PubMed  Google Scholar 

  32. Andlauer O, Moore H, Rico T, et al. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep. 2012;35:1247–55.

    PubMed  PubMed Central  Google Scholar 

  33. Peterson PC, Husain AM. Pediatric narcolepsy. Brain Dev. 2008;30:609–23.

    Article  PubMed  Google Scholar 

  34. Challamel MJ. Hypersomnia in children. In: Billiard M, editor. Sleep-physiology, investigation and medicine. New York: Kluwer Academic/Plenum Publishers; 2003. p. 457–68.

    Google Scholar 

  35. Wise MS. Child Narcolepsy. 1998;50 Suppl 1:S37–42.

    CAS  Google Scholar 

  36. Nevsimalova S. Narcolepsy in childhood. Sleep Med Rev. 2009;13:169–80.

    Article  PubMed  Google Scholar 

  37. Plazzi G, Pizza F, Palaia V, et al. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011;134:3480–92.

    Article  Google Scholar 

  38. Pizza F, Franceschini C, Peltola H, et al. Clinical and polysomnographic course of childhood narcolepsy with cataplexy. Brain. 2013;136:3787–95.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Aran A, Lin L, Nevsimalova S, et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep. 2009;32:979–83.

    PubMed  PubMed Central  Google Scholar 

  40. Natarajan N, Jain SV, Chaudhry H, et al. Narcolepsy-cataplexy: is streptococcal infection a trigger? J Clin Sleep Med. 2013;9:269–70.

    PubMed  PubMed Central  Google Scholar 

  41. Challamel MJ, Mazzola ME, Nevšímalová S, et al. Sleep. 1994;17 Suppl 8:S17–20.

    CAS  PubMed  Google Scholar 

  42. Pisko J, Pastorek L, Buskova J, et al. Nightmares in narcolepsy – under-investigated symptom? Sleep Med. 2014;15:967–72.

    Article  PubMed  Google Scholar 

  43. Nevsimalova S, Prihodova I, Kemlink D, et al. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Med. 2007;8:784–6.

    Article  PubMed  Google Scholar 

  44. Vernet C, Arnulf A. Narcolepsy with long sleep time: a specific entity? Sleep. 2009;32:1229–35.

    PubMed  PubMed Central  Google Scholar 

  45. Kotagal S, Krahn LE, Slocumb N. A putative link between childhood narcolepsy and obesity. Sleep Med. 2004;5:147–50.

    Article  PubMed  Google Scholar 

  46. Inocente CO, Lavault S, Lecendreux M, et al. Impact of obesity in children with narcolepsy. CNS Neurosci Ther. 2013;19:521–8.

    Article  PubMed  Google Scholar 

  47. Lammers GJ, Pijl H, Iestra J, et al. Spontaneous food choice in narcolepsy. Sleep. 1996;19:75–6.

    CAS  PubMed  Google Scholar 

  48. Kok SW, Overeem S, Visscher TL, et al. Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity. Obes Res. 2003;11:1147–54.

    Article  CAS  PubMed  Google Scholar 

  49. Plazzi G, Parmeggiani A, Mignot E, et al. Narcolepsy-cataplexy associated with precocious puberty. Neurology. 2006;66:1577–9.

    Article  CAS  PubMed  Google Scholar 

  50. Poli F, Pizza F, Mignot E, et al. High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy. Sleep. 2013;36:175–81.

    PubMed  PubMed Central  Google Scholar 

  51. Inocente CO, Gustin MP, Lauvault S, Perret AG, Christol N, et al. Quality of life in children with narcolepsy. CNS Neurosci Ther. 2014;20:763–71.

    Article  PubMed  Google Scholar 

  52. Kubota H, Kanbayashi T, Tanabe Y, et al. Decreased cerebrospinal fluid hypocretin-1 levels near the onset of narcolepsy in 2 prepubertal children. Sleep. 2003;26:555–7.

    PubMed  Google Scholar 

  53. Savvidou A, Knudsen S, Olsson-Engman M, et al. Hypocretin deficiency develops during onset of human narcolepsy with cataplexy. Sleep. 2013;36:147–8.

    PubMed  PubMed Central  Google Scholar 

  54. Mignot E, Hayduk R, Black J, et al. HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep. 1997;20:1012–20.

    CAS  PubMed  Google Scholar 

  55. Kotagal S, Hartse KM, Walch JK. Characteristics of narcolepsy in pre-teenaged children. Pediatrics. 1990;85:205–9.

    CAS  PubMed  Google Scholar 

  56. Han F, Lin L, Li J, et al. Presentation of primary hypersomnia in Chinese children. Sleep. 2011;5:627–32.

    Google Scholar 

  57. Jambhekar SK, Com G, Jones E, et al. Periodic limb movements during sleep in children with narcolepsy. J Clin Sleep Med. 2011;7:597–601.

    PubMed  PubMed Central  Google Scholar 

  58. Dauvilliers Y, Montplaisir Molinari N, et al. Age at onset of narcolepsy in two large populations of patients in France and Quebeck. Neurology. 2001;57:2029–33.

    Article  CAS  PubMed  Google Scholar 

  59. Dauvilliers Y, Gosselin A, Paquet J, et al. Effect of age on MSLT results in patients with narcolepsy-cataplexy. Neurology. 2004;62:46–50.

    Article  CAS  PubMed  Google Scholar 

  60. Aran A, Einen M, Lin L, et al. Clinical and therapeutic aspects of childhood-narcolepsy-cataplexy: a retrospective study of 51 children. Sleep. 2010;33:1457–64.

    PubMed  PubMed Central  Google Scholar 

  61. Nevsimalova S, Roth B, Zouhar A, Zemanova H. The occurrence of narcolepsy-cataplexy and periodic hypersomnia in early childhood. In: Koella WP, Obal F, Schulz H, Wisser P, editors. Sleep ’86. Stuttgart: Gustav Fisher Verlag; 1988. p. 399–401.

    Google Scholar 

  62. Bouvier E, Arnulf I, Claustrat B, et al. Do children with idiopathic narcolepsy have a long sleep time? Sleep. 2009;32(Suppl):A97.

    Google Scholar 

  63. Mignot E. Genetic and familial aspects of narcolepsy. Neurology. 1998;50 Suppl 1:S16–22.

    Article  CAS  PubMed  Google Scholar 

  64. Martinez-Orozco FJ, Vicario JL, Villalibre-Valderrey I, et al. J Sleep Res. 2014;23:414–9.

    Article  PubMed  Google Scholar 

  65. Nevšímalová S, Mignot E, Šonka K, Arrigoni JL. Genetic aspects of narcolepsy-cataplexy in the Czech Republic. Sleep. 1997;20:1021–6.

    PubMed  Google Scholar 

  66. Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human marcoleptic brains. Nat Med. 2000;6:991–7.

    Article  CAS  PubMed  Google Scholar 

  67. Guilleminault C, Fromherz S. Narcolepsy. diagnosis and management. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier Sounders; 2007. p. 780–90.

    Google Scholar 

  68. Greenhil LL, Pliszka S, Dulcan MK, et al. Practice parameter for the use of stimulant medication in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry. 2002;41 Suppl 2:26S–49.

    Article  Google Scholar 

  69. Lecendreux M, Bruni O, Franco P, et al. Clinical experience suggests that modafinil is an effective and safe treatment for paediatric narcolepsy. J Sleep Res. 2012;21:481–3.

    Article  PubMed  Google Scholar 

  70. Davies M, Wilton L, Shakir S. Safety profile of modafinil across a range of prescribing indications, including off-label use, in a primary care setting in England. Drug Saf. 2013;36:237–46.

    Article  PubMed  Google Scholar 

  71. Lecendreux M, Poli F, Oudertte D, et al. Tolerance and efficacy of sodium oxybate in childhood narcolepsy with cataplexy: a retrospective study. Sleep. 2012;35:709–11.

    PubMed  PubMed Central  Google Scholar 

  72. Mansukhani MP, Kotagal S. Sodium oxybate in the treatment of childhood narcolepsy-cataplexy: a retrospective study. Sleep Med. 2012;13:606–10.

    Article  PubMed  Google Scholar 

  73. Kotagal S. Hypersomnia in children. Sleep Med Clin. 2012;7:379–89.

    Article  Google Scholar 

  74. American Academy of Sleep Medicine. International classification of sleep disorders. Diagnostic and coding manual. 2nd ed. Westchester: American Academy of Sleep Medicine; 2005.

    Google Scholar 

  75. Billiard M. From narcolepsy with cataplexy to idiopathic hypersomnia without long sleep time. Sleep Med. 2009;10:943–4.

    Article  PubMed  Google Scholar 

  76. Sonka K, Susta M, Billiard M. Narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time: a cluster analysis. J Sleep Res. 2015;16:225–31.

    Google Scholar 

  77. Roth B, Nevsimalova S, Sagova V, et al. Neurological, psychological and polygraphic findings in sleep drunkenness. Schweiz Arch Neurol Neurochir Psychiatr. 1981;129:209–22.

    CAS  PubMed  Google Scholar 

  78. Billiard M, Merle C, Carlander B, et al. Idiopathic hypersomnia. Psychiatr Clin Neurosci. 1998;52:125–9.

    Article  CAS  Google Scholar 

  79. Kanbayashi T, Inoue Y, Chiba S, et al. CSF hypocretin-1 (orexin-A) concentration in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res. 2002;11:91–3.

    Article  PubMed  Google Scholar 

  80. Nevsimalova S, Blazejova K, Illnerova H, et al. A contribution to pathophysiology of idiopathic hypersomnia. In: Ambler Z, Nevsimalova S, Kadanka Z, Rossini PM, editors. Clinical neurophysiology at the beginning of the 21st century. Suppl Clin Neurophysiol. 2000;53:366–70.

    Google Scholar 

  81. Billiard M, Dauvilliers Y. Idiopathic hypersomnia. Sleep Med Rev. 2001;5:349–58.

    Article  PubMed  Google Scholar 

  82. Billiard M. Idiopathic hypersomnia. In: Thorpy MJ, Billiard M, editors. Sleepiness: causes, consequences and treatment. Cambridge: Cambridge University Press; 2011. p. 126–35.

    Chapter  Google Scholar 

  83. Nevsimalova-Bruhova S, Roth B. Heredofamilial aspects of narcolepsy and hypersomnia. Schweiz Arch Neurol Neurochir Psychiat. 1972;110:45–54.

    CAS  Google Scholar 

  84. Janackova S, Motte J, Bakchine S, Sforza E. Idiopathic hypersomnia: a report of three adolescent-onset cases in a two-generation family. J Child Neurol. 2011;26:522–5.

    Article  PubMed  Google Scholar 

  85. Nevsimalova S. Idiopathic hypersomnia. In: Chokroverty S, Billiard M, editors. Sleep medicine. a comprehensive guide to its development, clinical milestones, and advances in treatment. New York: Springer; 2015. p. 223–8.

    Google Scholar 

  86. Lavault S, Dauvilliers Y, Drouot X, et al. Benefit and risk of modafinil in idiopathic hypersomnia vs. narcolepsy. Sleep Med. 2011;12:550–6.

    Article  PubMed  Google Scholar 

  87. Mayer G, Benes H, Young P, et al. Modafinil in the treatment of idiopathic hypersomnia without long sleep time – a randomized, double-blind, placebo-controlled study. J Sleep Res. 2015;24:74–81.

    Article  PubMed  Google Scholar 

  88. Remdurg S. Kleine-Levin syndrome: etiology, diagnosis, and treatment. Ann Indian Acad Neurol. 2010;13:241–6.

    Article  Google Scholar 

  89. Arnulf I, Zeitzer JM, File J, et al. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain. 2005;2763–76.

    Google Scholar 

  90. Arnulf I, Lin L, Gadoth N, et al. Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol. 2008;63:482–92.

    Article  CAS  PubMed  Google Scholar 

  91. Ramnath B, Kalaniti K. Kleine-Levin syndrome. Indian Pediatr. 2008;45:1007.

    CAS  PubMed  Google Scholar 

  92. Nevšímalová S, Roth B, Zouhar A, Zemanová H. The occurrence of narcolepsy-cataplexy and periodic hypersomnia in infancy and early childhood. In: Koella WP, Obal F, Schultz H, Visser P, editors. Sleep 1986. Stuttgart: Gustav Fischer Verlag; 1988. p. 399–401.

    Google Scholar 

  93. Huang YS, Lin YH, Guilleminault C. Polysomnography in Kleine-Levin syndrome. Neurology. 2008;70:795–801.

    Article  PubMed  Google Scholar 

  94. Sethi S, Bhargava SC. Kleine-Levin syndrome and encephalitis. Indian J Pediatr. 2002;69:999–1000.

    Article  PubMed  Google Scholar 

  95. Das A, Radhakrishnan A. A case of PANDAS with Kleine-Levin type hypersomnia. Sleep Med. 2012;13:319–20.

    Article  PubMed  Google Scholar 

  96. Huang JC, Liao HT, Yeh GC, Hung KL. Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome. J Clin Neurosci. 2012;19:628–30.

    Article  CAS  PubMed  Google Scholar 

  97. Dauvilliers Y, Baumann CR, Carlander B, et al. CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiat. 2003;74:1167–73.

    Article  Google Scholar 

  98. Kas A, Lavault S, Habert MO, Arnulf I. Feeling unreal: a functional imaging study in patients with Kleine-Levin syndrome. Brain. 2014;137:2077–87.

    Article  PubMed  Google Scholar 

  99. Huang YS, Guilleminault C, Kao PF, Liu FY. SPECT findings in Kleine-Levin syndrome. Sleep. 2005;28:955–60.

    PubMed  Google Scholar 

  100. Billiard M, Jaussent I, Dauvilliers Y, Besset A, et al. Recurrent hypersomnias: a review of 339 cases. Sleep Med Rev. 2011;15:247–57.

    Article  PubMed  Google Scholar 

  101. Loganathan S, Manjunath S, Jhirwal OP, et al. Lithium prophylaxis in Kleine-Levin syndrome. J Neuropsychiatry Clin Neurosci. 2009;21:107–8.

    Article  PubMed  Google Scholar 

  102. Mukaddes NM, Kora ME, Bilge S. Carbamazepine for Kleine-Levin syndrome. J Am Acad Child Adolesc Psychiatry. 1999;38:791.

    Article  CAS  PubMed  Google Scholar 

  103. Itokawa K, Fukui M, Ninomiya M, et al. Gabapentin for Kleine-Levin syndrome. Inter Med. 2009;48:1183–5.

    Article  Google Scholar 

  104. Ortega-Albas JJ, Diaz JR, Lopez-Bernabe R, et al. Treatment of Kleine-Levin syndrome with sodium oxybate. Sleep Med. 2011;12:730–1.

    Article  PubMed  Google Scholar 

  105. Osorio MB, Kurowski BG, Beebe D, et al. Association of daytime somnolence with executive functioning in the first 6 months after adolescent traumatic injury. PM R. 2013;5:554–662.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Milroy G, Dorris L, McMillan TM. Sleep disturbance following mild traumatic brain injury in childhood. J Pediatr Psychol. 2008;33:242–7.

    Article  CAS  PubMed  Google Scholar 

  107. Stores G, Stores R. Sleep disorders in children with traumatic brain injury: a case of serious neglect. Dev Med Child Neurol. 2013;55:797–805.

    Article  PubMed  Google Scholar 

  108. Owens JA, Fernando S, Mc Guinn M. Sleep disturbance and injury risk in young children. Behav Sleep Med. 2005;3:18–31.

    Article  PubMed  Google Scholar 

  109. Li Y, Jin H, Owens JA, Hu C. The association between sleep and injury among school-aged children in rural China: a case control study. Sleep Med. 2008;9:142–8.

    Article  PubMed  Google Scholar 

  110. Rafii F, Oskouie F, Shoghi M. The association between sleep and injury among school-aged children in Iran. Sleep Dis. 2013. http://dx.doi.org/10.1155/2013/891090.

  111. Nevsimalova S, Malinova V. Cataplexy and sleep disorders in Niemann-Pick disease type C. Curr Neurol Neurosci Rep. 2015;15:522–9.

    Article  PubMed  CAS  Google Scholar 

  112. Rosen GM, Bendel AE, Neglia JP, et al. Sleep in children with neoplasms of the central nervous system: a case review of 14 children. Pediatrics. 2003;112:e46–54.

    Article  PubMed  Google Scholar 

  113. Gapstur R, Gross CR, Ness K. Factors associated with sleep-wake disturbances in child and adult survivors of pediatric brain tumors: a review. Oncol Nurs Forum. 2009;36:723–31.

    Article  PubMed  Google Scholar 

  114. Verberne LM, Maurice-Stam H, Grootenhuis MA, et al. Sleep disorders in children after treatment for a CNS tumour. J Sleep Res. 2012;21:461–9.

    Article  PubMed  Google Scholar 

  115. Poretti A, Grotzer MA, Ribi K, et al. Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol. 2004;46:220–9.

    Article  PubMed  Google Scholar 

  116. Muller HL, Muller-Stover S, Gebhardt U, et al. Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. J Pediatr Endocrinol. 2006;19 Suppl 1:423–9.

    Google Scholar 

  117. Marcus CL, Trescher WH, Halbower AS, Lutz J. Secondary narcolepsy in children with brain tumors. Sleep. 2002;25:435–9.

    PubMed  Google Scholar 

  118. Muller HK, Handwerker G, Gebhardt U, et al. Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control. 2006;17:583–9.

    Article  PubMed  Google Scholar 

  119. Muller HK, Handwerker G, Wollny B, et al. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metab. 2002;87:3993–6.

    Article  CAS  PubMed  Google Scholar 

  120. Kothare SV, Kaleyias J. Sleep and epilepsy in children and adolescents. Sleep Med. 2010;11:674–85.

    Article  PubMed  Google Scholar 

  121. Izumi N, Mizuguchi H, Umehara, et al. Evaluation on efficacy and sedative profiles of H(1) antihistamines by large-scale surveillance using the visual analogue scale (VAS). Allergol Intern. 2008;57:257–63.

    Article  Google Scholar 

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  1. Department of Neurology, Charles University and General Teaching Hospital, Katerinska 30, Prague, Czech Republic

    Soňa Nevšímalová

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  1. Department of Neurology, Charles University and General Teaching Hospital, Prague, Czech Republic

    Soňa Nevšímalová

  2. Sapienza University, S. Andrea Hospital, Department of Developmental and Social Psychology, Rome, Roma, Italy

    Oliviero Bruni

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Nevšímalová, S. (2017). Disorders Associated with Increased Sleepiness. In: Nevšímalová, S., Bruni, O. (eds) Sleep Disorders in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-28640-2_13

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