Abstract
Tumour necrosis factor-α (TNF) has been discovered as a major regulator of inflammation. This protein was also identified as an essential role player in the cytokine network. As a pluripotent mediator, TNF- α affects number of cellular/molecular pathways including adhesion, migration, angiogenesis and apoptosis. It is a member of TNF family which is largely produced by T-cells and macrophages. Its main function is the regulation of immune system by activating T-cells, B-cells and macrophages in order to induce other cytokine’s expression and cell adhesion molecules. Furthermore, the prominent expression of TNF- α in blood vessels endothelial cells reflects its role during wound healing. It has been reported that TNF- α has an indirect angiogenic role, depending on the synthesis of secondary mediators such as vascular endothelial growth factor (VEGF). However, its dual angiogenic (pro/anti) roles in different conditions have been made it difficult to understand. Overall, TNF- α dysregulation has been connected to various human inflammatory diseases in addition to several malignancies.
Dr. Haleh Vosgha contributed equally with Dr. Ali Salajegheh.
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Salajegheh, A. (2016). Tumour Necrosis Factor-α (TNF-α). In: Angiogenesis in Health, Disease and Malignancy. Springer, Cham. https://doi.org/10.1007/978-3-319-28140-7_56
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DOI: https://doi.org/10.1007/978-3-319-28140-7_56
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