Synonyms
Ameloblastoma of mucosal origin; Ameloblastoma of the gingiva; Basal cell carcinoma of the gingiva; Extraosseous ameloblastoma; Peripheral ameloblastoid hamartoma; Soft tissue ameloblastoma
Definition
The peripheral ameloblastoma is an uncommon benign odontogenic neoplasm, exhibiting histopathologic features of conventional intraosseous solid and multicystic ameloblastoma but arising within the soft tissue overlying tooth-bearing areas of the jaws. The lesion likely originates from rests of the dental lamina or basal epithelial cells of the surface epithelium. Compared to its intraosseous counterpart, the peripheral ameloblastoma exhibits a more limited growth potential and lower recurrence rate. Because of its relatively innocuous clinical behavior, some investigators have proposed that the lesion may represent a hamartoma, although most authorities prefer to regard it as a true neoplasm.
There are a few lesions that have been reported as “basal cell carcinomas of the...
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References and Further Reading
Buchner, A., & Sciubba, J. J. (1987). Peripheral epithelial odontogenic tumours: A review. Oral Surgery, Oral Medicine, and Oral Pathology, 63(6), 688–697.
Koutlas, I. G., Koch, C. A., Vickers, R. A., Brouwers, F. M., & Vortmeyer, A. O. (2009). An unusual ostensible example of intraoral basal cell carcinoma. Journal of Cutaneous Pathology, 36(4), 464–470.
Lentini, M., Simone, A., & Carrozza, G. (2004). Peripheral amleoblastoma: Use of cytokeratin 19 and Ber-EP4 to distinguish it from basal cell carcinoma. Oral Oncology Extra, 40, 79–80.
Nodit, L., Barnes, L., Childers, E., Finkelstein, S., Swalsky, P., & Hunt, J. (2004). Allelic loss of tumour suppressor genes in ameloblastic tumours. Modern Pathology, 17(9), 1062–1067.
Philipsen, H. P., Reichart, P. A., Nikai, H., Takata, T., & Kudo, Y. (2001). Peripheral ameloblastoma: Biological profile based on 160 cases from the literature. Oral Oncology, 37(1), 17–27.
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Chi, A. (2016). Ameloblastoma, Peripheral. In: Slootweg, P.J. (eds) Dental and Oral Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28085-1_655
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DOI: https://doi.org/10.1007/978-3-319-28085-1_655
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