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The Renaissance of Neurospora crassa: How a Classical Model System is Used for Applied Research

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Gene Expression Systems in Fungi: Advancements and Applications

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

One major focus in fungal biotechnological research is the elucidation of plant biomass degradation. Filamentous fungi have the capacity to produce large amounts of enzymes for lignocellulose deconstruction that release fermentable sugars from the plant cell walls. The most commonly used fungi for this purpose are Trichoderma reesei and several Aspergilli. However, the saprophytic ascomycete Neurospora crassa has already made undeniable contributions to fundamental science in the past, and due to the availability of versatile tools for genetics, biochemistry and molecular biology, it is well suited to be applied also to industrially relevant questions. In this review, we try to highlight not only the capacity of Neurospora crassa as a biomass degrader and how recent advances in genomic, proteomic and transcriptomic studies promote the understanding of the underlying processes, but also to introduce the biotechnological potential of Neurospora crassa itself.

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Acknowledgement

We thank Louise Glass, Morgann Reilly, Jamie Cate, and Tian Chaoguang for critical reading of the manuscript, and we are grateful to John Taylor for advice with Fig. 1.

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  1. Holzforschung München, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany

    Tanja Seibert M.Sc., Nils Thieme M.Sc. & J. Philipp Benz

  2. Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany

    Tanja Seibert M.Sc.

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  1. Tanja Seibert M.Sc.
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  2. Nils Thieme M.Sc.
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  3. J. Philipp Benz
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Correspondence to J. Philipp Benz .

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  1. and Environment-Bioresources, AIT Austrian Institute of Technology Department of Health, Tulln, Australia

    Monika Schmoll

  2. and Environment-Bioresources, AIT Austrian Institute of Technology Department of Health, Tulln, Australia

    Christoph Dattenböck

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Seibert, T., Thieme, N., Benz, J.P. (2016). The Renaissance of Neurospora crassa: How a Classical Model System is Used for Applied Research. In: Schmoll, M., Dattenböck, C. (eds) Gene Expression Systems in Fungi: Advancements and Applications. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-319-27951-0_3

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