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Extracellular Matrix and Tissue Regeneration

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Regenerative Medicine - from Protocol to Patient

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Abstract

Extracellular matrix (ECM) is an important component of stem cell niche areas, which provide residence, regulate stem cell pool size and control stem cell mobilization. ECM is a complex interlinked composite of collagenous molecules, non-collagenous molecules and water-rich mucopolysaccharide ground substance. Cells are integrated to their matrix via integrin and non-integrin receptors, which control adhesion, migration, division, growth, anoikis, transdifferentiation and other cellular behaviour. ECM safeguard cells and tissue architecture and strength, but also growth factor deposits, which proteinases as signalling scissors can release in a site- and process-specific manner. Selected processes, like wound healing, cartilage and heart ECM, and tumor growth are used to exemplify participation of ECM in tissue regenerative processes.

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Aknowledgements

This work was supported EU Matera grant “Bioactive Nanocomposite Constructs for Regeneration of Articular Cartilage”, European Science Foundation “Regenerative Medicine” RNP, Danish Council for Strategic Research, Finska Lakaresallskapet, Orion Foundation and EU COST 533 Biotribology Action.

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Authors and Affiliations

  1. Department of Regenerative Medicine, State Research Institute Center for Innovative Medicine, Santariškių Str.5, LT-08406, Vilnius, Lithuania

    Zygmunt Mackiewicz

  2. Department of Medicine, Institute of Clinical Medicine, Haartmaninkatu 8, 00029 HUS, Helsinki, Finland

    Yrjö Tapio Konttinen, Emilia Kaivosoja, Vasily Stegajev & Jaakko Levón

  3. COXA Hospital for Joint Replacement, Biokatu 6 b, 33520, Tampere, Finland

    Yrjö Tapio Konttinen

  4. ORTON Orthopaedic Hospital, ORTON Foundation, Tenholantie 10, 00280, Helsinki, Finland

    Yrjö Tapio Konttinen & Veli-Matti Tiainen

  5. Department of Materials and Interfaces, Weizmann Institute of Science, 76100, Rehovot, Israel

    Hanoch Daniel Wagner

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  1. Zygmunt Mackiewicz
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  2. Yrjö Tapio Konttinen
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  3. Emilia Kaivosoja
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  5. Hanoch Daniel Wagner
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  7. Veli-Matti Tiainen
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Correspondence to Zygmunt Mackiewicz .

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  1. Department of Cardiac Surgery and Refere, University of Rostock, Rostock, Mecklenburg-Vorpomm., Germany

    Gustav Steinhoff

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Mackiewicz, Z. et al. (2016). Extracellular Matrix and Tissue Regeneration. In: Steinhoff, G. (eds) Regenerative Medicine - from Protocol to Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-27583-3_1

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