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B-Cell Non-Hodgkin’s Lymphomas with Lymphoplasmacytoid and Plasmacytic Features

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

The liver can be infiltrated in lymphoplasmacytic lymphoma (LPL), a neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, a disease usually involving bone marrow and less commonly lymph nodes and inner organs. LPL is often associated with production of a paraprotein, usually of the IgM type (Waldenström’s disease). LPL of the liver may rarely be a primary process, but in most cases liver infiltration is the manifestation of generalized LPL. Hepatic infiltration is usually located to portal tracts, but rarely large tumor masses can develop, and compression of small blood vessels may cause portal hypertension. LPL is sometimes associated with peliosis hepatis. The liver is a known manifestation organ of plasmacytoma. In most cases, the liver participates in cases with systemic neoplastic disease. Diffuse, nodular, and mixed hepatic growth patterns of plasmacytoma are known. The rare disorder, plasma cell leukemia, can involve the liver, more frequently in primary plasma cell leukemia than in the secondary form that develops in the setting of plasmacytoma.

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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Zimmermann, A. (2017). B-Cell Non-Hodgkin’s Lymphomas with Lymphoplasmacytoid and Plasmacytic Features. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_92

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