Abstract
A distinct spectrum of disorders causing biliary obstruction is characterized by eosinophilic infiltration. Eosinophilic cholangiopathy denotes an alteration characterized by an increased infiltration of bile duct walls with eosinophils, associated with stenosing bile duct fibrosis. The disorder may be combined with eosinophilic cholecystitis. In part of cases, bile duct fibrosis is severe, mimicking sclerosing cholangitis. Rare forms show additional granuloma formation that also involves liver tissue (eosinophilic granulomatous cholangiohepatitis). In forms that extend into the liver substance, eosinophilic abscesses may develop. These intraparenchymal lesions can develop a vigorous inflammatory reaction followed by inflammatory fibrosis, ending up in mass lesions mimicking liver tumors (eosinophilic pseudotumors).
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Zimmermann, A. (2017). Reactive Bile Duct Alterations Mimicking Biliary Cancer: Eosinophilic Cholangitis/Cholangiopathy and Other Eosinophilic Disorders. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_143
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