Abstract
Bioactive polymers, by their structural configuration and conformation, possess the ability to exert biological activities and consequently elicit responses from cells and tissues. Intelligent polymers are smart polymers which respond to internal and external stimuli in order to propel the release or modify the release of drugs. Natural polymers are biogenic, biocompatible, biodegradable, and safe for consumption. Consequently, they present as suitable materials that the human body can identify with and not treat as foreign bodies, thereby reducing the complications encountered when dealing with synthetic polymers. Natural polymers have been shown to be bioactive, exhibiting biological activities such as antitumor, anticoagulant, antioxidant, antimicrobial, antiulcer, anti-inflammatory, and antirheumatic. In addition, natural polymers are meritorious materials for the fabrication of self-regulated or externally regulated drug delivery systems. These systems respond to the state of the environment for efficacious therapy. Drug delivery technology is shifting from the controlled release of drugs over time to the release of drugs when and where needed, especially for chronic diseases. Indeed, intelligent polymers are choice polymers for such delivery systems. Their synthetic counterparts were actually synthesized to mimic these natural polymers which further buttress the need to revert to nature for intelligent and bioactive polymers. The contexts of natural bioactive and intelligent polymers have unique applications in drug delivery, embracing nanobiotechnology. This would ultimately benefit drug delivery systems in benchmarking new drug formulations.
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References
Ngwuluka NC, Ochekpe NA, Aruoma OI (2014) Polymers 6:1312–1332
Ngwuluka NC, Ochekpe N (2015) In: Mishra M (ed) Encyclopedia of biomedical polymers and polymeric biomaterials. Taylor & Francis, New York, NY, 11 volume set
Sullivan R, Smith JE, Rowan NJ (2006) Perspect Biol Med 49:159–170
Taguchi T, Furue H, Kimura T, Kondo T, Hattori T, Itoh I et al (1985) Gan To Kagaku Ryoho 12:366–378
Kidd PM (2000) Altern Med Rev 5:4–27
Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME (1999) Proc Soc Exp Biol Med 221:281–293
Kimura Y, Tojima H, Fukase S, Takeda K (1994) Acta Otolaryngol 114:192–195
Niimoto M, Hattori T, Tamada R, Sugimachi K, Inokuchi K, Ogawa N (1988) Jpn J Surg 18:681–686
Nakazato H, Koike A, Saji S, Ogawa N, Sakamoto J, Nakazato H et al (1994) The Lancet 343:1122–1126
Okudaira Y, Sugimachi K, Inokuchi K, Kai H, Kuwano H, Matsuura H (1982) Jpn J Surg 12:249–256
Ogoshi K, Satou H, Isono K, Mitomi T, Endoh M, Sugita M (1995) Cancer Invest 13:363–369
Go P, Chung C (1989) J Int Med Res 17:141–149
Torisu M, Hayashi Y, Ishimitsu T, Fujimura T, Iwasaki K, Katano M et al (1990) Cancer immunology. Immunotherapy 31:261–268
Mitomi T, Tsuchiya S, Iijima N, Aso K, Suzuki K, Nishiyama K et al (1992) Dis Colon Rectum 35:123–130
Si-Iiojima SKK, Furuta M, Niibe H (1993) Anticancer Res 13:1815–1820
Liu J, Zhou J (1993) Anonymous PSP international symposium, Fudan University Press, Hong Kong, pp 183
Sun Z, Yang Q, Fei H (1999) In: Yang, Q. (ed), Advanced Research in PSP. Hong Kong Association for Health Care Ltd., Hong Kong, pp. 304–307.
Gonzaga MLC, Bezerra DP, Alves APNN, de Alencar NMN, de Oliveira Mesquita R, Lima MW et al (2009) J Nat Med 63:32–40
Yan J, Wang W, Li L, Wu J (2011) Carbohydr Polym 85:753–758
Li N, Li L, Fang JC, Wong JH, Ng TB, Jiang Y et al (2012) Biosci Rep 32:221–228
Nagaoka M, Shibata H, Kimura-Takagi I, Hashimoto S, Aiyama R, Ueyama S et al (2000) Biofactors 12:267
Han S, Lee CW, Kang MR, Yoon YD, Kang JS, Lee KH et al (2006) Cancer Lett 243:264–273
Zong A, Cao H, Wang F (2012) Carbohydr Polym 90:1395–1410
Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher A et al (1999) Carbohydr Res 319:154–165
Dobashi K, Nishino T, Fujihara M, Nagumo T (1989) Carbohydr Res 194:315–320
Colliec S, Fischer A, Tapon-Bretaudiere J, Boisson C, Durand P, Jozefonvicz J (1991) Thromb Res 64:143–154
Cáceres PJ, Carlucci MJ, Damonte EB, Matsuhiro B, Zúñiga EA (2000) Phytochemistry 53:81–86
de Souza MCR, Marques CT, Dore CMG, da Silva FRF, Rocha HAO, Leite EL (2007) J Appl Phycol 19:153–160
Huang Y, Li R (2014) Mar Drugs 12:4379–4398
Rupérez P, Ahrazem O, Leal JA (2002) J Agric Food Chem 50:840–845
Wang J, Zhang Q, Zhang Z, Li Z (2008) Int J Biol Macromol 42:127–132
Kim S, Choi D, Athukorala Y, Jeon Y, Senevirathne M, Rha CK (2007) J Food Sci Nutr 12:65–73
Wijesekara I, Pangestuti R, Kim S (2011) Carbohydr Polym 84:14–21
Lauder RM (2009) Complement Ther Med 17:56–62
Vergés J, Montell E, Herrero M, Perna C, Cuevas J, Dalmau J et al (2005) Dermatol Online J 11:31
Hori Y, Hoshino J, Yamazaki C, Sekiguchi T, Miyauchi S, Horie K (2001) Jpn J Pharmacol 85:155–160
Dumelod BD, Ramirez RPB (1999) Int J Food Sci Nutr 50:283
Jang JS, Lee JS, Lee JH, Kwon DS, Lee KE, Lee SY et al (2010) Arch Pharm Res 33:853–861
Smit AJ (2004) J Appl Phycol 16:245–262
Witvrouw M, De Clercq E (1997) Gen Pharmacol Vascular Syst 29:497–511
Ghosh T, Chattopadhyay K, Marschall M, Karmakar P, Mandal P, Ray B (2009) Glycobiology 19:2–15
Bo S, Muschin T, Kanamoto T, Nakashima H, Yoshida T (2013) Carbohydr Polym 94(2):899–903
Jeon K, Katsuraya K, Inazu T, Kaneko Y, Mimura T, Uryu T (2000) J Am Chem Soc 122:12536–12541
Hirano S, Nagao N (1989) Agric Biol Chem 53:3065–3066
Jeon Y, Park P, Kim S (2001) Carbohydr Polym 44:71–76
Volod’ko AV, Davydova VN, Chusovitin E, Sorokina IV, Dolgikh MP, Tolstikova TG et al (2014) Carbohydr Polym 101:1087–1093
Shibata H, Kimura-Takagi I, Aiyama R, Nagaoka M, Ueyama S, Yokokura T et al (2000) Biofactors 11:235
Panlasigui LN, Baello OQ, Dimatangal JM, Dumelod BD (2003) Asia Pac J Clin Nutr 12:209–214
Tsuge K, Okabe M, Yoshimura T, Sumi T, Tachibana H, Yamada K (2004) Food Sci Technol Res 10:147–151
Pengzhan Y, Quanbin Z, Ning L, Zuhong X, Yanmei W, Zhi’en L (2003) J Appl Phycol 15:21–27
Onishi T, Umemura S, Yanagawa M, Matsumura M, Sasaki Y, Ogasawara T et al (2008) Arch Oral Biol 53:257–260
Gazi MI (1991) J Clin Periodontol 18:75–77
Clark DT, Gazl MI, Cox SW, Eley BM, Tinsley GF (1993) J Clin Periodontol 20:238–243
Moon HJ, Lee SR, Shim SN, Jeong SH, Stonik VA, Rasskazov VA et al (2008) Biol Pharm Bull 31:284–289
Armisen R, Galatas F (1987) In: McHugh DJ (ed) Production and utilization of products from commercial seaweeds, vol 288., pp 1–57
Wu J, Ding X (2001) J Agric Food Chem 49:501–506
Ardizzoni A, Neglia R, Baschieri M, Cermelli C, Caratozzolo M, Righi E et al (2011) J Mater Sci Mater Med 22:2329–2338
Liu M, Wu K, Mao X, Wu Y, Ouyang J (2010) J Ethnopharmacol 127:32–37
Lu J, Chen X, Zhang Y, Xu J, Zhang L, Li Z et al (2013) Int J Mol Med 31:1463–1470
Cheng Y, Tang K, Wu S, Liu L, Qiang C, Lin X et al (2011) PLoS One 6, e27437
Dai H, Jia G, Liu X, Liu Z, Wang H (2014) Environ Toxicol Pharmacol 38:263–271
da Silva BP, Parente JP (2003) Carbohydr Polym 51:239–242
Nakashima H, Yoshida O, Baba M, De Clercq E, Yamamoto N (1989) Antiviral Res 11:233–246
Coombe DR, Harrop HA, Watton J, Mulloy B, Barrowcliffe TW, Rider CC (1995) AIDS Res Hum Retroviruses 11:1393–1396
Guzdek A, Rokita H (1997) Mediators Inflamm 6:58–63
Delattre C, Fenoradosoa TA, Michaud P (2011) Braz Arch Biol Technol 54:1075–1092
Hayashi T, Hayashi K, Maeda M, Kojima I (1996) J Nat Prod 59:83–87
Pujol C, Matulewicz M, Cerezo A, Damonte E (1998) Phytomedicine 5:205–208
Maji PK, Sen IK, Devi KSP, Maiti TK, Sikdar SR, Islam SS (2013) Carbohydr Res 368:22–28
Yoo S, Yoon EJ, Cha J, Lee HG (2004) Int J Biol Macromol 34:37–41
Liu J, Luo J, Ye H, Zeng X (2012) Food Chem Toxicol 50:767–772
Giavasis I (2014) Curr Opin Biotechnol 26:162–173
Shingel KI (2004) Carbohydr Res 339:447–460
Zhong K, Wang Q, He Y, He X (2010) Int J Biol Macromol 47:356–360
Recuenco FC, Kobayashi K, Ishiwa A, Enomoto-Rogers Y, Fundador NGV, Sugi T et al (2014) Scientific Rep 4:4723
Panilaitis B, Johri A, Blank W, Kaplan D, Fuhrman J (2002) Clin Diagn Lab Immunol 9:1240–1247
de Oliveira AJB, Cordeiro LM, Gonçalves RAC, Ceole LF, Ueda-Nakamura T, Iacomini M (2013) Carbohydr Polym 94:179–184
Evans T (2002) Aliment Pharmacol Ther 16:6–11
Liao W-R, Lin J-Y, Shieh W-Y, Jeng W-L, Huang R (2003) J Ind Microbiol Biotechnol 30:433
Teixeira EH, Arruda FVS, do Nascimento KS, Carneiro VA, Nagano CS, da Silva BR et al (2012) In: Chang C-F (ed) Carbohydrates – comprehensive studies on glycobiology and glycotechnology. InTech, Croatia, pp 533–558
Mitsumata T, Suemitsu Y, Fujii K, Fujii T, Taniguchi T, Koyama K (2003) Polymer 44:7103–7111
Aiedeh K, Taha MO (1999) Arch Pharm (Weinheim) 332:103–107
Huang Y, Lam U (2011) J Chin Chem Soc 58:779–785
Ngwuluka NC, Choonara YE, Modi G, du Toit LC, Kumar P, Ndesendo VM et al (2013) AAPS PharmSciTech 14:605–619
Lee SJ, Park K (1996) J Mol Recognit 9:549–557
Brownlee M, Cerami A (1979) Science 206:1190–1191
Jeong SY, Kim SW, Holmberg DL, McRea JC (1985) J Control Release 2:143–152
Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M (2005) J Control Release 103:609–624
Zhang Y, Gao C, Li X, Xu C, Zhang Y, Sun Z et al (2014) Carbohydr Polym 101:171–178
Ying L, Jiali S, Jiang G, Jia Z, Fuxin D (2007) Chin J Chem Eng 15:566–572
Bhattarai N, Gunn J, Zhang M (2010) Adv Drug Deliv Rev 62:83–99
Chen J, Cheng T (2009) Polymer 50:107–116
Fundueanu G, Constantin M, Ascenzi P (2008) Biomaterials 29:2767–2775
Miyazaki S, Suzuki S, Kawasaki N, Endo K, Takahashi A, Attwood D (2001) Int J Pharm 229:29–36
Kim SJ, Shin SR, Lee JH, Lee SH, Kim SI (2003) J Appl Polym Sci 90:91–96
Sun S, Mak AF (2001) J Polym Sci B 39:236–246
Rozier A, Mazuel C, Grove J, Plazonnet B (1997) Int J Pharm 153:191–198
Rozier A, Mazuel C, Grove J, Plazonnet B (1989) Int J Pharm 57:163–168
Itoh K, Yahaba M, Takahashi A, Tsuruya R, Miyazaki S, Dairaku M et al (2008) Int J Pharm 356:95–101
Gao X, Matsui H (2005) Adv Mater 17:2037–2050
Bong DT, Clark TD, Granja JR, Ghadiri MR (2001) Angew Chem Int Ed 40:988–1011
Fernandez-Lopez S (2001) Nature 412:452
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Ngwuluka, N.C., Ochekpe, N.A., Aruoma, O.I. (2016). Functions of Bioactive and Intelligent Natural Polymers in the Optimization of Drug Delivery. In: Hosseini, M., Makhlouf, A. (eds) Industrial Applications for Intelligent Polymers and Coatings. Springer, Cham. https://doi.org/10.1007/978-3-319-26893-4_8
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