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Reactive Bile Duct Alterations Mimicking Biliary Cancer: Inflammatory Conditions

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract
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Abstract

Several inflammatory conditions of the biliary tract can mimic biliary cancer, resulting in biliary obstruction and jaundice. Following ulcerating cholangitis, granulation tissue formation can result in inflammatory polyps that may grow to rather large size to obstruct bile duct lumen. In part of cases, foreign bodies such as suture material induces granulation tissue polyps. Mass-forming lesions are also produced by various types of granulomatous cholangitis, including sarcoidosis, Crohn’s disease, and tuberculosis. Duct stenosis may be caused by numerous mucosal lymph follicles (follicular cholangitis). A distinct form of recurrent cholangitis that may result in bile duct scarring and associated with stone casts is oriental cholangitis. Similar to the gallbladder, large bile ducts can undergo xanthogranulomatous inflammation. A rare condition is cholesterolosis of bile ducts, which can produce cholesterol polyps.

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Zimmermann, A. (2016). Reactive Bile Duct Alterations Mimicking Biliary Cancer: Inflammatory Conditions. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26587-2_142-1

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