Skip to main content
SpringerLink
Log in

Hepatobiliary Pseudotumors Consisting of Nonneoplastic Hematopoietic Cells and Cells of the Macrophage Lineage

  • Living reference work entry
  • First Online:
Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

  • 243 Accesses

Abstract

The hepatobiliary tract can develop tumor-like lesions or pseudotumors that consist of hematopoietic tissue or macrophage accumulations. Extramedullary hematopoiesis can occur in the liver and may result in macroscopically visible nodular lesions (nodular extramedullary hematopoiesis). Macroscopically, the lesions may have several cm in diameter and usually show a red-brown or tan color. One variant is characterized by the production of an abundant fibrous stroma (sclerosing extramedullary hematopoietic tumor). The liver can be the site of various eosinophilic pseudotumors and eosinophilic necrosis. Macrophage-rich lesions of the liver that can result in tumor-like nodular lesions comprise lipogranulomas, xanthomatous lesions, rheumatoid nodules, malakoplakia, and accumulations of Gaucher cells in Gaucher’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Abbitt PL, Teates CD (1989) The sonographic appearance of extramedullary hematopoiesis in the liver. J Clin Ultrasound 17:280–282

    Article  CAS  PubMed  Google Scholar 

  • Abedin et al. 2003. http://www.ncbi.nlm.nih.gov/pubmed/12714580

  • Ackerman et al. 1982. http://www.ncbi.nlm.nih.gov/pubmed/7042896

  • Ackerman et al. 2002. http://www.ncbi.nlm.nih.gov/pubmed/11834744

  • Addison T, Gull W (1851) On a certain affection of the skin, Vitiligoidea – A. plana, B. tuberosa, with remarks. Guys Hosp Rev 7:265

    Google Scholar 

  • Agnarsdottir M, Willen R, El Hag IA (2004) Three cases of malacoplakia of the gallbladder. Ups J Med Sci 109:255–259

    Article  PubMed  Google Scholar 

  • Altshuler CH, Angevine DM (1949) Histochemical studies on the pathogenesis of fibrinoid. Am J Pathol 25:1061–1077

    CAS  PubMed  PubMed Central  Google Scholar 

  • Altwegg M, Hinrickson HP (1999) Shigella boydii as cause of malakoplakia in a human immunodeficiency virus-infected patient. Clin Infect Dis 29:1602

    Article  CAS  PubMed  Google Scholar 

  • Andersen T, Christoffersen P, Gluud C (1984) The liver in consecutive patients with morbid obesity: a clinical, morphological, and biochemical study. Int J Obes 8:107–115

    CAS  PubMed  Google Scholar 

  • Anderson JM (2000) Multinucleated giant cells. Curr Opin Hematol 7:40–47

    Article  CAS  PubMed  Google Scholar 

  • Andresen B, Blum J, von Weymarn A, Burge M, Steinbrich W, Duewell S (2000) Hepatic fascioliasis: report of two cases. Eur Radiol 10:1713–1715

    Article  CAS  PubMed  Google Scholar 

  • Ask-Upmark E (1945) Tumours simulating intrathoracic heterotopia of bone marrow. Acta Radiol 26:425–440

    Article  Google Scholar 

  • Aterman K, Remmele W, Smith M (1988) Karl Touton and his “xanthelamatic giant cell”. A selective review of multinucleated giant cells. Am J Dermatopathol 10:257–269

    Article  CAS  PubMed  Google Scholar 

  • Aytac S, Fitoz S, Akyar S, Atasoy C, Erekul S (1999) Focal intrahepatic extramedullary hematopoiesis: color Doppler US and CT findings. Abdom Imaging 24:366–368

    Article  CAS  PubMed  Google Scholar 

  • Azuma et al. 2002. http://www.ncbi.nlm.nih.gov/pubmed/12041704

  • Bajema IM, Bruijn JA (2000) What stuff is this! A historical perspective on fibrinoid necrosis. J Pathol 191:235–238

    Article  CAS  PubMed  Google Scholar 

  • Bajema IM, Hagen EC, de Heer E, Bruijn JA (1998) The PAF-Halmi staining distinguishes two types of glomerular fibrinoid necrosis in systemic vasculitis. J Am Soc Nephrol 9:532A

    Google Scholar 

  • Banerjee 1990. http://www.ncbi.nlm.nih.gov/pubmed/2317437

  • Bar J, Linke T, Ferlinz K, Neumann U, Schuchman EH, Sandhoff K (2001) Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Hum Mutat 17:199–209

    Article  CAS  PubMed  Google Scholar 

  • Ben Rejeb A, Haouala H, Ben Hammadi F, Ben Othman M, Khelil A, Gueddiche M, Ben Cheikh M, Rokbani L (1992) Pseudotumor extramedullary hematopoiesis. Report of 3 cases and review of literature (in French). Ann Pathol 12:183–187

    CAS  PubMed  Google Scholar 

  • Benbow EW (1990) Xanthogranulomatous cholecystitis. Br J Surg 77:255–256

    Article  CAS  PubMed  Google Scholar 

  • Bendikov-Bar I, Horowitz M (2012) Gaucher disease paradigm: from ERAD to comorbidity. Hum Mutat 33:1398–1407

    Article  CAS  PubMed  Google Scholar 

  • Berney T, Chautems R, Ciccarelli O, Latinne D, Pirson Y, Squifflet JP (1999) Malakoplakia of the caecum in a kidney-transplant recipient: presentation as acute tumoral perforation and fatal outcome. Transpl Int 12:293–296

    Article  CAS  PubMed  Google Scholar 

  • Bhatia and Sarin 1994. http://www.ncbi.nlm.nih.gov/pubmed/8147371

  • Blewitt RW, Bradbury K, Greenall MJ et al (1977) Hepatic damage associated with mineral oil deposits. Gut 18:476–479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bohte et al. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23554863

  • Burns and Sarkany 1979. http://www.ncbi.nlm.nih.gov/pubmed/535175

  • Byrne et al. 1976. http://www.ncbi.nlm.nih.gov/pubmed/999311

  • Boitnott JK, Margolis S (1970) Saturated hydrocarbons in human tissues: III. Oil droplets in the liver and spleen. Johns Hopkins Med J 127:65–78

    CAS  PubMed  Google Scholar 

  • Bothe AE, van Dussen L, Akkerman EM, Nederveen AJ, Sinkus R, Jansen PL, Stoker J et al (2013) Liver fibrosis in type I Gaucher disease: magnetic resonance imaging, transient elastography and parameters of iron storage. PLoS One 8:e57507

    Article  CAS  Google Scholar 

  • Botros N, Yan SR, Wanless IR (2014) Malakoplakia of liver: report of two cases. Pathol Res Pract 210:459–462

    Article  PubMed  Google Scholar 

  • Boucher LD, Aoki M, Lee EY, Cibull ML (1994) Malakoplakia of liver associated with a perforated colonic diverticulum. A case report and review of the literature. J Clin Gastroenterol 19:318–320

    Article  CAS  PubMed  Google Scholar 

  • Bradley MJ, Metreweli C (1990) Sonography of extramedullary hematopoiesis of the liver. AJR Am J Roentgenol 154:900–901

    Article  CAS  PubMed  Google Scholar 

  • Breiden-Langen et al. 1991. http://www.ncbi.nlm.nih.gov/pubmed/16511436

  • Caffey J, Silverman WA (1945) Infantile cortical hyperostosis: preliminary report on a new syndrome. AJR Am J Roentgenol 54:1–16

    Google Scholar 

  • Caterino-de-Araujo A, de los Santos-Fortuna E, Zandona-Meleiro MC, Calore EE, Perez Calore NM (2000) Detection of the 20-kDA virulence-associated antigen of Rhodococcus equi in malakoplakia-like lesion in pleural tissue obtained from an AIDS patient. Pathol Res Pract 196:321–327

    Article  CAS  PubMed  Google Scholar 

  • Chantranuwat C (2004) Systemic form of juvenile xanthogranuloma: report of a case with liver and bone marrow involvement. Pediatr Dev Pathol 7:646–648

    Article  PubMed  Google Scholar 

  • Charpentier P, Prade M, Bognel C, Gadenne C, Duvillard P (1983) Malacoplakia of the gallbladder. Hum Pathol 14:827–828

    Article  CAS  PubMed  Google Scholar 

  • Chen M, Wang J (2008) Gaucher disease: review of the literature. Arch Pathol Lab Med 132:851–853

    PubMed  Google Scholar 

  • Chen CS, Lai MK, Hsueh S, Hwang TL, Chuang CK (1994) Renal malacoplakia with secondary hepato-duodenal involvement. J Urol 151:982–985

    CAS  PubMed  Google Scholar 

  • Cho TJ, Moon HJ, Cho DY, Park MS, Lee DY, Yoo WJ, Chung CY, Choi IH (2008) The c.3040C > T mutation in COL1A1 is recurrent in Korean patients with infantile cortical hyperostosis (Caffey disease). J Hum Genet 53:947–949

    Article  CAS  PubMed  Google Scholar 

  • Cho ES, Yu JS, Kim MJ, Kim JH, Chung JJ, Kim KW (2010) Focal eosinophilic necrosis on superparamagnetic iron oxide-enhanced MRI. AJR Am J Roentgenol 194:1296–1302

    Article  PubMed  Google Scholar 

  • Choi JI, Lee JM, Kim SH, Lee JY, Lee MW, Han CK, Choi BI (2009) Differentiating focal eosinophilic necrosis of the liver from hepatic metastases using unenhanced and portal venous phase computed tomographic imagings: results of univariate and multivariate statistical analyses. J Comput Assist Tomogr 33:705–709

    Article  PubMed  Google Scholar 

  • Christensen AH, Ishak KG (1970) Benign tumors and pseudotumors of the gallbladder. Report of 180 cases. Arch Pathol 90:423–432

    CAS  PubMed  Google Scholar 

  • Christoffersen P, Braendstrup O, Juhl E, Poulsen H (1971) Lipogranulomas in human liver biopsies with fatty change. A morphological, biochemical and clinical investigation. Acta Pathol Microbiol Scand A 79:150–158

    CAS  PubMed  Google Scholar 

  • Chvostek F (1911) Xanthelasma und Ikterus. Ztschr f Klein Med 73:476

    Google Scholar 

  • Cohen PR (2009) Neutrophilic dermatoses: a review of current treatment options. Am J Clin Dermatol 10:301–312

    Article  PubMed  Google Scholar 

  • Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC et al (2003) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348:1201–1214

    Article  CAS  PubMed  Google Scholar 

  • Cools J, Stover EH, Wlodarska I, Marynen P, Gilliland DG (2004) The FIP1L1-PDGFRalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia. Curr Opin Hematol 11:51–57

    Article  CAS  PubMed  Google Scholar 

  • Couret M, Combe B, Chuong VT, Leroux JL, Blotman F, Sany J (1988) Rheumatoid nodulosis: report of two cases and discussion of diagnostic criteria. J Rheumatol 15:1427–1430

    CAS  PubMed  Google Scholar 

  • Coutre S, Gotlib J (2004) Targeted treatment of hypereosinophilic syndromes and chronic eosinophilic leukemias with imatinib mesylate. Semin Cancer Biol 14:23–31

    Article  CAS  PubMed  Google Scholar 

  • Da Costa JL, Loh YS, Hanam E (1974) Extramedullary hemopoiesis with multiple tumor-simulating mediastinal masses in hemoglobin E-thalassemia disease. Chest 65:210–212

    Article  PubMed  Google Scholar 

  • Damjanov I, Moriber Katz S (1981) Malakoplakia. Pathol Annu 16:103–126

    CAS  PubMed  Google Scholar 

  • Dardi LE, Marzano M, Froula E (1990) Fine needle aspiration cytologic diagnosis of focal intrahepatic extramedullary hematopoiesis. Acta Cytol 34:567–569

    CAS  PubMed  Google Scholar 

  • Dasgupta P, Womack C, Turner AG, Blackford HN (1999) Malacoplakia: von Hansemann’s disease. BJU Int 84:464–469

    Article  CAS  PubMed  Google Scholar 

  • De Fost M, vom Dahl S, Weverling GJ, Brill N, Brett S, Häussinger D et al (2006) Increased incidence of cancer in adult Gaucher disease in Western Europe. Blood Cells Mol Dis 36:53–58

    Article  PubMed  Google Scholar 

  • De Rycke L, Baeten D, Foell D et al (2005) Differential expression and response to anti-TNF alpha treatment by infiltrating versus resident tissue macrophage subsets in autoimmune arthritis. J Pathol 206:17–27

    Article  PubMed  CAS  Google Scholar 

  • De Saint-Maur P, Gallot D (1990) Hepatic malacoplakia as a complication of polycystosis (in French). Ann Pathol 10:50–51

    PubMed  Google Scholar 

  • De Vincentiis C (1883) Endothelioma adiposo. Riv Clin 35:481–501

    Google Scholar 

  • Debnath CR, Debnath MR, Nabi N, Khan NA, Chakraborty S (2013) A case of Gaucher’s disease progressing to liver cirrhosis. Mymensingh Med J 22:394–396

    CAS  PubMed  Google Scholar 

  • Delbrel X, Germain P, Fach J, Etienne G, Beylot C, Parrens M, De Mascarel A, Le Bras M et al (2001) Cutaneous pyoderma gangrenosum with hepatosplenic localization and monoclonal gammopathy. A case report (in French). Ann Med Interne (Paris) 152:65–67

    CAS  Google Scholar 

  • Delladetsima JK, Horn T, Poulsen H (1987) Portal tract lipogranulomas in liver biopsies. Liver 7:9–17

    Article  CAS  PubMed  Google Scholar 

  • Desmet VJ (1995) Histopathology of cholestasis. Verh Dtsch Ges Pathol 79:233–240

    CAS  PubMed  Google Scholar 

  • Dewar G, Leung NWY, Ng HK, Bradley M, Li AKC (1990) Massive, solitary, intrahepatic, extramedullary hematopoietic tumor in thalassemia. Surgery 107:704–707

    CAS  PubMed  Google Scholar 

  • Di Tommaso L, Arizzi C, Roncalli M (2005) Malacoplakia of the gallbladder. Histopathology 46:474–475

    Article  PubMed  Google Scholar 

  • Dincsoy HP, Weesner RE, MacGee J (1982) Lipogranulomas in non-fatty human livers. A mineral oil induced environmental disease. Am J Clin Pathol 78:35–41

    Article  CAS  PubMed  Google Scholar 

  • Dyer et al. 1997. http://www.ncbi.nlm.nih.gov/pubmed/9119387

  • Ehlert K, Frosch M, Fehse N, Zander A, Roth J, Vormoor J (2007) Farber disease: clinical presentation, pathogenesis and a new approach to treatment. Pediatr Rheumatol 5:15

    Article  Google Scholar 

  • el Bawab S, Mao C, Obeid LM, Hannun YA (2002) Ceramidases in the regulation of ceramide levels and function. Subcell Biochem 36:187–205

    Article  PubMed  Google Scholar 

  • Eriguchi N, Aoyagi S, Horiuchi H, Tamae T, Uchida S, Hiraki M, Nishimura K, Kawabata M, Hamada S (2002) Xanthogranulomatous cholecystitis with a liver abscess and metastatic endophthalmitis: report of a case. Surg Today 32:285–288

    Article  PubMed  Google Scholar 

  • Erikson A (1986) Gaucher disease – Norrbottnian type (III). Neuropaediatric and neurobiological aspects of clinical patterns and treatment. Acta Paediatr Scand Suppl 326:1–42

    Article  CAS  PubMed  Google Scholar 

  • Esparza AR, Mckay DB, Cronan JJ et al (1981) Renal parenchymal malakoplakia. Histologic spectrum and its relationship to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis. Am J Surg Pathol 13:225–236

    Article  Google Scholar 

  • Fahr Th (1918) Zur Frage des Rheumatismus nodosus. Zbl Path 29:625

    Google Scholar 

  • Ferrazzi V, Rivière S, Sany J (1996) Association of pyoderma gangrenosum with hepato-pancreatic involvement in rheumatoid polyarthritis (in French). Rev Med Interne 17:266–267

    Article  CAS  PubMed  Google Scholar 

  • Ferrell LD, Lee R, Brixko C, Bass NM, Lake JR, Roberts JP, Ascher N, Rabkin J (1995) Hepatic granulomas following liver transplantation. Clinicopathologic features in 42 patients. Transplantation 60:926–933

    Article  CAS  PubMed  Google Scholar 

  • Fleming KA, Zimmerman H, Shubnik P (1998) Granulomas in the livers of humans and Fischer rats associated with the ingestion of mineral hydrocarbons: a comparison. Regul Toxicol Pharmacol 27:75–81

    Article  CAS  Google Scholar 

  • Franco V, Aragona F, Genova G, Florena AM, Stella M, Campesi G (1990) Xanthogranulomatous cholecystitis. Histopathological study and classification. Pathol Res Pract 186:383–390

    Article  CAS  PubMed  Google Scholar 

  • Fried K, Manor A, Pajewski M, Starinsky R, Vure E (1981) Autosomal dominant inheritance with incomplete penetrance in Caffey disease (infantile cortical hyperostosis). Clin Genet 19:271–274

    Article  CAS  PubMed  Google Scholar 

  • Futcher TB (1905) Xanthelasma and chronic jaundice. Am J Med Sci 130:939–951

    Article  Google Scholar 

  • Gans O (1964) Zur Geschichte der Vereinigung südwestdeutscher Dermatologen. Hautarzt 15:623–625

    CAS  PubMed  Google Scholar 

  • Garcia-Patos V (2007) Rheumatoid nodule. Semin Cutan Med Surg 26:100–107

    Article  CAS  PubMed  Google Scholar 

  • Gensure RC, Mäkitie O, Barcklay C, Chan C, DePalma SR, Bastepe M, Abuzahra H et al (2005) A novel COL1A1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. J Clin Invest 115:1250–1257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gil-Fernandez JJ, Martinez-Chamorro C, Tomas JF (2001) The irreplaceable image: a giant hepatic mass of myeloid metaplasia in a patient without myelofibrosis. Haematologica 86:445

    CAS  PubMed  Google Scholar 

  • Ginsberg MH, Genant HK, Yu TF, McCarty DJ (1975) Rheumatoid nodulosis: an unusual variant of rheumatoid disease. Arthritis Rheum 18:49–58

    Article  CAS  PubMed  Google Scholar 

  • Gitlin D, Craig JM, Janeway CA (1957) Studies on the nature of fibrinoid in the collagen diseases. Am J Pathol 33:55–77

    CAS  PubMed  PubMed Central  Google Scholar 

  • Glorieux FH (2005) Caffey disease: an unlikely collagenopathy. J Clin Invest 115:1142–1144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goldberg GM, Saphir O (1960) Lipidosis of the liver portal spaces: I. A study of its relationship to the lymphatics of the liver. Arch Pathol Lab Med 69:586–593

    CAS  Google Scholar 

  • Goni MA, Scheines EJ, Paira SO, Barcelo HA, Maldonado Cocco JA (1992) Rheumatoid nodulosis: a puzzling variant of rheumatoid arthritis. Clin Rheumatol 11:396–401

    Article  CAS  PubMed  Google Scholar 

  • Gotlib J, Cools J, Malone JM, Schrier SL, Gilliland DG, Coutre SE (2004) The FIP1L1-PDGFR(alpha) fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and managment. Blood 104:2879–2891

    Article  CAS  Google Scholar 

  • Gougerot M (1935) Karl Touton. Bull Soc Fr Dermatol Syphiligr 42:413–415

    Google Scholar 

  • Green et al. 1985. http://www.ncbi.nlm.nih.gov/pubmed/4067029

  • Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R (2003) Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A 100:7830–7835

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gruber GB (1930) 6. Die Leber bei Erkrankungen des blut-und lymphbildenden Gewebs-Apparates. In: Henke F, Lubarsch O (eds) Handbuch der speziellen pathologischen Anatomie und Histologie, Vol. 5, Verdauungsdrüsen, Erster Teil, Leber. Julius Springer, Berlin, pp 669–672

    Google Scholar 

  • Gualco G, Ojopi EB, Chioato L, Cordeiro DL, Negretti F, Bacchi CE (2010) Postsplenectomy sclerosing extramedullary hematopoietic tumor with unexpected good clinical evolution: morphologic, immunohistochemical, and molecular analysis of one case and review of the literature. Appl Immunohistochem Mol Morphol 18:291–295

    Article  CAS  PubMed  Google Scholar 

  • Guerrero MF, Ramos JM, Renedo G, Gadea I, Alix A (1999) Pulmonary malacoplakia associated with Rhodococcus equi infection in patients with AIDS: case report and review. Clin Infect Dis 28:1334–1336

    Article  CAS  PubMed  Google Scholar 

  • Gupta P, Naran A, Auh YH, Chung JS (2004) Focal intrahepatic extramedullary hematopoiesis presenting as fatty lesions. AJR Am J Roentgenol 182:1031–1032

    Article  PubMed  Google Scholar 

  • Hadas-Halpem I, Deeb M, Abrahamov A, Zimran A, Elstein D (2010) Gaucher disease: spectrum of sonographic findings in the liver. J Ultrasound Med 29:727–733

    Google Scholar 

  • Han JK, Choi BI, Cho JM, Chung KB, Han MC, Kim CW (1993) Radiological findings of human fascioliasis. Abdom Imaging 18:261–264

    Article  CAS  PubMed  Google Scholar 

  • Han JK, Han D, Choi BI, Han MC (1996) MR findings in human fascioliasis. Trop Med Int Health 1:367–372

    Article  CAS  PubMed  Google Scholar 

  • Han JK, Jang HJ, Choi BI, Kim SH, Kim TK, Won HJ, Kim YI, Cho SY (1999) Experimental hepatobiliary fascioliasis in rabbits: a radiology-pathology correlation. Invest Radiol 34:99–108

    Article  CAS  PubMed  Google Scholar 

  • Hardaway W (1884) Xanthoma multiplex. J Cutan Vener Dis 354:20

    Google Scholar 

  • Hart FD (1994) Rheumatoid nodules. Ann Rheum Dis 53:83

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hartman G, Yong SL, Chejfec G (2002) Malakoplakia of liver diagnosed by a needle core biopsy: a case report and review of the literature. Arch Pathol Lab Med 126:372–374

    PubMed  Google Scholar 

  • Hastier P, Caroli-Bosc FX, Bartel HR, Harris AG, Maes B, Arpurt JP, Taillan B, Bodock I et al (1996) Pyoderma gangrenosum with hepatopancreatic manifestations in a patient with rheumatoid arthritis. Dig Dis Sci 41:594–597

    Article  CAS  PubMed  Google Scholar 

  • Hayashi et al. 1999. http://www.ncbi.nlm.nih.gov/pubmed/10475929

  • Heimpel H, Dührsen U, Hofbauer P, Rigamonti-Wermlinger V, Kreuser ED, Schwarz K et al (2009) Bulky extramedullary hematopoiesis is not a rare complication of congenital dyserythropoietic anemia. Ann Hematol 88:937–941

    Article  PubMed  Google Scholar 

  • Herman TE (1996) Antenatal-onset cortical hyperostosis and nonimmune hydrops. J Perinatol 16:137–139

    CAS  PubMed  Google Scholar 

  • Hervé S, Savoye G, Savoye-Collet C, Behbahani A, Auliac JB, Bota S, François A, Lerebours E (2001) Intrahepatic extramedullary hematopoiesis as a manifestation of a malignant thymoma: an unusual cause of nodular hepatomegaly (in French). Gastroenterol Clin Biol 25:711–713

    PubMed  Google Scholar 

  • Herxheimer K (1935) Karl Touton. Dermatol Zschr 70:247–248

    Article  Google Scholar 

  • Hide G, Desai S, Bloxham CA (2001) Malakoplakia of the gallbladder: imaging and histological features. Clin Radiol 56:326–328

    Article  CAS  PubMed  Google Scholar 

  • Highton J, Kean A, hessian P, Wilsher M (2000) Cells expressing dendritic cell markers are present in the rheumatic nodule. J Rheumatol 27:339–346

    CAS  PubMed  Google Scholar 

  • Highton J, Hessian PA, Stamp L (2007) The rheumatoid nodule: peripheral or central to rheumatoid arthritis? Rheumatology (Oxford) 46:1385–1387

    Article  CAS  Google Scholar 

  • Ho KJ (1979) Michaelis-Gutmann bodies. Arch Pathol Lab Med 103:488–489

    CAS  PubMed  Google Scholar 

  • Holubar K (1990) Looking back…Paul Langerhans, Theodor Langhans, and Carl Touton – contemporary histopathologists. Am J Dermatopathol 12:534–535

    Article  CAS  PubMed  Google Scholar 

  • Hruska KS, LaMarca ME, Scott CR, Sidransky E (2008) Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA). Hum Mutat 29:567–583

    Article  CAS  PubMed  Google Scholar 

  • Hulkova H, Ledvinova J, Poupetova H, Kohout A, Malinova V, Elleder M (2009) Autopsy case of Gaucher disease type I in a patient on enzyme replacement therapy. Comments on the dynamics of persistent storage process. J Inherit Metab Dis 32:551–559

    Article  CAS  PubMed  Google Scholar 

  • Hur J, Park MS, Yu JS, Lim JS, Hong SW, Kim KW (2005) Focal eosinophilic necrosis versus metastasis in the liver: the usefulness of two-phase dynamic CT. AJR Am J Roentgenol 184:1085–1090

    Article  PubMed  Google Scholar 

  • Iversen K, Christoffersen P, Poulsen H (1970) Epithelioid cell granulomas in liver biopsies. Scand J Gastroenterol Suppl 7:61–67

    CAS  PubMed  Google Scholar 

  • Jang HJ, Lee WJ, Lee SJ, Kim SH, Lim HK, Lim JH (2002) Focal eosinophilic necrosis of the liver in patients with underlying gastric or colorectal cancer: CT differentiation from metastasis. Korean J Radiol 3:240–244

    Article  PubMed  PubMed Central  Google Scholar 

  • Jelali MA, Luciani A, Kobeiter H, Zafrani S, Anglade MC, Zegai B et al (2006) MRI features of intrahepatic extramedullary haematopoiesis in sickle cell anaemia. Cancer Imaging 6:182–185

    Article  PubMed  PubMed Central  Google Scholar 

  • Kamishima T, ito K, Awaya H, Mitchell DG (2000) MR imaging of bilateral renal malakoplakia after liver transplantation. AJR Am J Roentgenol 175:919–920

    Article  CAS  PubMed  Google Scholar 

  • Kamoun-Goldrat A, le Merrer M (2008) Infantile cortical hyperostosis (Caffey disease). A review. J Oral Maxillofac Surg 66:2145–2150

    Article  PubMed  Google Scholar 

  • Kamoun-Golsdrat A, Martinovic J, Saada J, Sonigo-Cohen P, Razavi F, Munnich A, Le Mercier M (2008) Prenatal cortical hyperostosis with COL 1A1 gene mutation. Am J Med Genet A 146A:1820–1824

    Article  CAS  Google Scholar 

  • Kaye BR, Kaye RL, Bobrove A (1984) Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases. Am J Med 76:279–292

    Article  CAS  PubMed  Google Scholar 

  • Keen ME, Engstrand DA, Hafez GR (1985) Hepatic lipogranulomatosis simulating veno-occlusive disease of the liver. Arch Pathol Lab Med 109:70–72

    CAS  PubMed  Google Scholar 

  • Keitel W (2008) The pathologists: Aschoff, Klinge and Gräff (in German). Z Rheumatol 67:165–171

    Article  CAS  PubMed  Google Scholar 

  • Kim KA, Lim HK, Kim SH, Lee WJ, Lim JH (1999) Necrotic granuloma of the liver by human fascioliasis: imaging findings. Abdom Imaging 24:462–464

    Article  CAS  PubMed  Google Scholar 

  • Kim et al. 2002. http://www.ncbi.nlm.nih.gov/pubmed/12191679

  • Kim WH, Kim SH, Kim YH, Youn SH, Kang WJ, Kim MA, Han JK, Choi BI (2010) Fluorine-18-FDG PET findings of focal eosinophilic liver disease: correlation with CT and/or MRI, laboratory, and pathologic findings. Abdom Imaging 35:437–446

    Article  PubMed  Google Scholar 

  • Klatskin G (1977) Hepatic granulomata: problems in interpretation. Mt Sinai J Med 44:798–812

    CAS  PubMed  Google Scholar 

  • Klinger H (1932) Grenzformen der Periarteriitis nodosa. Frankf Z Pathol 42:455–480

    Google Scholar 

  • Klion AD, Noel P, Akin C, Law MA, Gilliland DG, Cools J, Metcalfe DD, Nutman TB (2003) Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood 101:4660–4666

    Article  CAS  PubMed  Google Scholar 

  • Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M, Metcalfe DD, Dunbar C, Nutman TB (2004a) Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood 103:473–478

    Article  CAS  PubMed  Google Scholar 

  • Klion AD, Law MA, Riemenschneider W, McMaster ML, Brown MR, Horne M, Karp B, Robinson M, Sachdev V et al (2004b) Familial eosinophilia: a benign disorder? Blood 103:4050–4055

    Article  CAS  PubMed  Google Scholar 

  • Koch J, Gartner S, Li CM, Quintern LE, Bernardo K, Levran O, Schnabel D, Desnick RJ, Schuchman EH, Sandhoff K (1996) Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification of the first molecular lesion causing Farber disease. J Biol Chem 271:33110–33115

    Article  CAS  PubMed  Google Scholar 

  • Koga M, Ishihara T, Uchino F, Fujiwaki T (1992) An autopsy case of Farber’s lipogranulomatosis in a Japanese boy with gastrointestinal involvement. Acta Pathol Jpn 42:42–48

    CAS  PubMed  Google Scholar 

  • Kopecky KK, Moriarty AT, Antony AC, Baker MK (1986) Extramedullary hematopoiesis in acute lymphocytic leukemia masquerading as hepatic, renal, and splenic microabscesses. AJR Am J Roentgenol 147:846–847

    Article  CAS  PubMed  Google Scholar 

  • Kumar A, Aggarwal S, de Tilly LN (1995) Case of the season: thalassemia major with extramedullary hematopoiesis in the liver. Semin Roentgenol 2:99–101

    Article  Google Scholar 

  • Kuriwaki K, Yoshida H (1999) Morphological characteristics of lipid accumulation in liver-constituting cells of acid lipase deficiency rats (Wolman’s disease model rats). Pathol Int 49:291–297

    Article  CAS  PubMed  Google Scholar 

  • Kwak HS, Lee JM (2000) CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis. J Korean Med Sci 15:460–462

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwak HS, Han YM, Lee JM (2004) Focal eosinophilic infiltration of the liver mimicking hepatocellular carcinoma; case reports. Clin Imaging 28:36–39

    Article  PubMed  Google Scholar 

  • Kwon Y, Yu E, Huh J, Lee SK, Ro JY (2004) Sclerosing extramedullary hematopoietic tumor involving the lesser omentum and ligamentum teres in liver explant. Ann Diagn Pathol 8:227–232

    Article  PubMed  Google Scholar 

  • La Fianza A, van der Byl G, Maccabelli G, Torretta L, Calliada F (2010) CT and MR findings in extramedullary haematopoiesis with biliary system encasement: a case report. J Radiol Case Rep 4:1–8

    PubMed  PubMed Central  Google Scholar 

  • Laghi F, Catalano O, Maresca M, Sandomenico F, Siani A (2010) Indeterminate, subcentimetric focal liver lesions in cancer patients: additional role of contrast-enhanced ultrasound. Ultraschall Med 31:283–288

    Article  CAS  PubMed  Google Scholar 

  • Landas SK, Mitros FA, Furst DE, LaBrecque DR (1992) Lipogranulomas and gold in the liver in rheumatoid arthritis. Am J Surg Pathol 16:171–174

    Article  CAS  PubMed  Google Scholar 

  • Lear JT, Atherton MT, Byrne JP (1997) Neutrophilic dermatosis: pyoderma gangrenosum and Sweet’s syndrome. Postgrad Med J 73:65–68

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lecolier B, Bercau G, Gonzalez M, Afriat R, Rambaud D, Mulliez N, de Kermadec S (1992) Radiographic, haematological, and biochemical findings in a fetus with Caffey disease. Prenat Diagn 12:637–641

    Article  CAS  PubMed  Google Scholar 

  • Lee WJ, Lim HK, Lim JH, Kim SH, Choi SH, Lee SJ (1999) Foci of eosinophil-related necrosis in the liver: imaging findings and correlation with eosinophilia. AJR Am J Roentgenol 172:1255–1261

    Article  CAS  PubMed  Google Scholar 

  • Lee IJ, Kim SH, Kim DS, Lee JM, Han JK, Choi BI (2008) Intrahepatic extramedullary hematopoiesis mimicking a hypervascular hepatic neoplasm on dynamic – and SPIO-enhanced MRI. Korean J Radiol 9(Suppl):S34–S38

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee MH, Kim SH, Kim H, Lee MW, Lee WJ (2011) Differentiating focal eosinophilic infiltration from metastasis in the liver with gadoxetic acid-enhanced magnetic resonance imaging. Korean J Radiol 12:439–449

    Article  PubMed  PubMed Central  Google Scholar 

  • Lefkowitch JH, Haythe JH, Regent N (2002) Kupffer cell aggregation and perivenular distribution in steatohepatitis. Mod Pathol 15:699–704

    Article  PubMed  Google Scholar 

  • Leiferman KM, Gleich GJ (2004) Hypereosinophilic syndrome: case presentation and update. J Allergy Clin Immunol 113:50–58

    Article  PubMed  Google Scholar 

  • Lemos LB, Baliga M, Benghuzzi HA, Cason Z (1997) Nodular hematopoiesis of the liver diagnosed by fine-needle aspiration cytology. Diagn Cytopathol 16:51–54

    Article  CAS  PubMed  Google Scholar 

  • Leonidas DD, Elbert BL, Zhou Z, Leffler H, Ackerman SJ, Acharya KR (1995) Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins. Structure 3:1379–1393

    Article  CAS  PubMed  Google Scholar 

  • Li CM, Park JH, Simonaro CM, He X, Gordon RE, Friedman AH, Ehleiter D, Paris F, Manova K, Hepbildikler S et al (2002) Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics 79:218–224

    Article  CAS  PubMed  Google Scholar 

  • Lim JH, Lee WJ, Lee DH, Nam KJ (2000) Hypereosinophilic syndrome: CT findings in patients with hepatic lobar or segmental involvement. Korean J Radiol 1:98–103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ma SK, Au WY (1999) Images in haematology. Hepatic haemopoiesis in beta-thalassemia trait. Br J Haematol 107:1

    Article  CAS  PubMed  Google Scholar 

  • Malamos B, Papavisiliou C, Avramidis A (1962) Tumor-simulating intrathoracic extramedullary hemopoiesis. Acta Radiol 57:227–231

    Article  CAS  PubMed  Google Scholar 

  • Marshall et al. 1978. http://www.ncbi.nlm.nih.gov/pubmed/285688

  • Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (1992) Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 1. Genomics 13:240–242

    Article  CAS  PubMed  Google Scholar 

  • Matsumura Y, Nishiwaki F, Morita N, Kore-Eda S, Miyachi Y (2011) Pyoderma gangrenosum in a patient with myelodysplastic syndrome followed by possible extracutaneous manifestations in the gallbladder, liver, bone and lung. J Dermatol 38:1102–1105

    Article  PubMed  Google Scholar 

  • McCarty DJ (1991) Complete reversal of rheumatoid nodulosis. J Rheumatol 18:736–737

    CAS  PubMed  Google Scholar 

  • McClure J, Cameron CHS, Garrett R (1981) The ultrastructural features of malakoplakia. J Pathol 134:13–25

    Article  CAS  PubMed  Google Scholar 

  • McCoy JJ, Vila R, Petrossian G, McCall RA, Reddy KS (1976) Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc 72:78–79

    PubMed  Google Scholar 

  • McNally AK, Anderson JM (1995) Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am J Pathol 147:1487–1499

    CAS  PubMed  PubMed Central  Google Scholar 

  • Meynet C (1875) Rhumatisme articulaire subaigu avec productions de tumeures multiples dans les tissus fibreux périarticulaires et sur le périoste d’un grand nombre d’os. Lyon Med 20:495

    Google Scholar 

  • Michaelis L, Gutmann C (1902) Ueber Einschlüsse in Blasentumoren. Z Klin Med 47:208–215

    Google Scholar 

  • Moldavskii MI, Rustamov IR (1984) Multichamber pseudocyts of the liver with malacoplakia (in Russian). Klin Khir 9:64–65

    PubMed  Google Scholar 

  • Morita Y, Ueno T, Sasaki N, Kuhara K, Yoshioka S, Tateishi Y, Nagata E, Kage M, Sata M (2005) Comparison of liver histology between patients with non-alcoholic steatohepatitis and patients with alcoholic steatohepatitis in Japan. Alcohol Clin Exp Res 29(12 Suppl):277S–281S

    Article  PubMed  Google Scholar 

  • Moschella SL (1970) Xanthomatosis, associated with multiple myeloma. Arch Dermatol 102:121–123

    Article  CAS  PubMed  Google Scholar 

  • Moskovitz B, Malberger E, Brenner B, Gaitini D, Vardi Y, Bolkier M (1991) Renal extramedullary hematopoiesis simulating hypernephroma. Eur Urol 19:343–345

    CAS  PubMed  Google Scholar 

  • Moxon W (1873) Simple stricture of hepatic duct, causing chronic jaundice and xanthelasma. Trans Path Soc Lond 129:129–134

    Google Scholar 

  • Muramatsu T, Sakai N, Yanagihara I, Yamada M, Nishigaki T, Kokubu C, Tsukamoto H, Ito M, Inui K (2002) Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease. J Inherit Metab Dis 25:585–592

    Article  CAS  PubMed  Google Scholar 

  • Murrell et al. 1997. http://www.ncbi.nlm.nih.gov/pubmed/9105307

  • Nam KJ, Jung WJ, Choi JC, Koo BS, Park BH, Lee KN, Han SY, Shin WW, Han SS (1999) Hepatic involvement in hypereosinophilia: sonographic findings. J Ultrasound Med 18:475–479

    CAS  PubMed  Google Scholar 

  • Navarro M, Crespo C, Perez L, Martinez C, Galant J, Gonzalez I (2000) Massive intrahepatic extramedullary hematopoiesis in myelofibrosis. Abdom Imaging 25:184–186

    Article  CAS  PubMed  Google Scholar 

  • Neumann E (1880) Die Picrocarminfärbung und ihre Anwendung auf die Entzündungslehre. Arch Mikrosk Anat 18:130–150

    Article  Google Scholar 

  • Nochomovitz LE, Uys CJ, Epstein S (1975) Massive deposition of mineral oil after prolonged ingestion. S Afr Med J 49:2187–2190

    CAS  PubMed  Google Scholar 

  • Noi I, Loberant N, Cohen I (1994) Inflammatory pseudotumor of the liver. Clin Imaging 18:283–285

    Article  CAS  PubMed  Google Scholar 

  • O’Malley DP (2007) Benign extramedullary myeloid proliferations. Mod Pathol 20:405–415

    Article  PubMed  Google Scholar 

  • Ourahma S, Barrou B, Bitker MO, Sylla C, Mouquet C, Chatelain C (1996) Rectal malakoplakia in a renal transplant recipient. Transplant Proc 28:2824

    CAS  PubMed  Google Scholar 

  • Palmer DG, Hogg N, Highton J, Hessian PA, Denholm I (1987a) Macrophage migration and maturation within rheumatoid nodules. Arthritis Rheum 30:729–736

    Article  Google Scholar 

  • Palmer DG, Hogg N, Allen CA, Highton J, Hessian PA (1987b) A mononuclear phagocyte subset associated with cell necrosis in rheumatoid nodules: identification with monoclonal antibody 5.5. Clin Immunol Immunopathol 45:17–28

    Article  CAS  PubMed  Google Scholar 

  • Papavisiliou C, Sfikakis P (1964) Tumour-simulating intrathoracic marrow heterotopia in thalassaemia major. Thorax 19:121–124

    Article  Google Scholar 

  • Pardanani A, Ketterling RP, Brockman SR, Flynn HC, Paternoster SF, Shearer BM et al (2003) CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood 102:3093–3096

    Article  CAS  PubMed  Google Scholar 

  • Parra JA, Acinas O, Bueno J, Guezmes A, Fernandez MA, Farinas MC (2000) Xanthogranulomatous cholecystitis: clinical, sonographic, and CT findings in 26 patients. AJR Am J Roentgenol 174:979–983

    Article  CAS  PubMed  Google Scholar 

  • Parwani AV, Ali SZ (2003) Pathologic quiz case. A 52-year-old woman with a liver mass. Arch Pathol Lab Med 127:631–632

    PubMed  Google Scholar 

  • Petersen P, Christoffersen P (1979) Ultrastructure of lipogranulomas in human fatty liver. Acta Pathol Microbiol Scand A 87:45–49

    Article  CAS  PubMed  Google Scholar 

  • Pettus BJ, Chalfant CE, Hannun YA (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 1585:114–125

    Article  CAS  PubMed  Google Scholar 

  • Pinocy J, Lange A, Konig C, Kaiserling E, Becker HD, Krober SM (2003) Xanthogranulomatous cholecystitis resembling carcinoma with extensive tumorous infiltration of the liver and colon. Langenbecks Arch Surg 388:48–51

    PubMed  Google Scholar 

  • Poll LW, vom Dahl S (2009) Image of the month. Hepatic gaucheroma mimicking focal nodular hyperplasia. Hepatology 50:985–986

    Article  PubMed  Google Scholar 

  • Poll LW, Koch JA, vom Dahl S, Loxtermann E, Sarbia M, Niederau C et al (2000) Extraosseous manifestation of Gaucher’s disease type I: MR and histological appearance. Eur Radiol 10:1660–1663

    Article  CAS  PubMed  Google Scholar 

  • Poll LW, Willers R, Häussinger D, Mödder U, vom Dahl S (2010) MRI bone marrow findings in 63 patients with type I Gaucher disease. Rofo 182:979–985

    Article  CAS  PubMed  Google Scholar 

  • Powell FC, Su WP, Pemy HO (1996) Pyoderma gangrenosum: classification and management. J Am Acad Dermatol 34:395–409

    Article  CAS  PubMed  Google Scholar 

  • Pulpeiro JR, Armesto V, Varela J, Corredoira J (1991) Fascioliasis: findings in 15 patients. Br J Radiol 64:798–801

    Article  CAS  PubMed  Google Scholar 

  • Pye Smith PH (1873) Xanthelasma (Vitiligoidea plana) of skin, peritoneum and mucous membrane, associated with jaundice: autopsy. Trans Path Soc Lond 24:250–253

    Google Scholar 

  • Raab SS, Silverman JF, McLeod DL, Geisinger KR (1993) Fine-needle aspiration cytology of extramedullary hematopoiesis (myeloid metaplasia). Diagn Cytopathol 9:522–526

    Article  CAS  PubMed  Google Scholar 

  • Raguin G, nemeth J, Wassef M et al (1999) Identification of Shigella boydii in colonic malakoplakia by universal bacterial 16S ribosomal DNA-based amplification in a human immunodeficiency virus-infected patient. Clin Infect Dis 28:142–143

    Article  CAS  PubMed  Google Scholar 

  • Rayer PFO (1835) Traité théorique et pratique des maladies de la peau. Baillière, Paris

    Google Scholar 

  • Reed A, Ryan C, Schwartz SI (1994) Xanthogranulomatous cholecystitis. J Am Coll Surg 179:249–252

    CAS  PubMed  Google Scholar 

  • Regragui A, Amrani M, Gamra L, Alaoui Belabbas M (2003) Malacoplakia of the biliary tract and duodenum. Case report (in French). Gastroenterol Clin Biol 27:655–656

    PubMed  Google Scholar 

  • Remstein ED, Kurtin PJ, Nascimento AG (2000) Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders. Am J Surg Pathol 24:51–55

    Article  CAS  PubMed  Google Scholar 

  • Riedlinger WF, Lairmore TC, Balfe DM, Dehner LP (2005) Tumefactive necrobiotic granulomas (nodulosis) of the pancreas in an adult with long-standing rheumatoid arthritis. Int J Surg Pathol 13:207–210

    Article  PubMed  Google Scholar 

  • Robertson SJ, Higgins RB, Powell C (1991) Malacoplakia of liver: a case report. Hum Pathol 22:1294–1295

    Article  CAS  PubMed  Google Scholar 

  • Roberts-Thomson PJ, Venables GS, Onitiri AC, Lewis B (1975) Polymeric IgA myeloma, hyperlipidemia and xanthomatosis: a further case and review. Postgrad Med J 51:44–51

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocha N, Suguiama EH, Maia D, Costa H, Coelho KI, Franco M (1997) Intestinal malakoplakia associated with paracoccidiodomycosis: a new association. Histopathology 30:79–83

    Article  CAS  PubMed  Google Scholar 

  • Rodot S, Lacour JP, Van Elslande L, Cognard C, Castanet J, Ortonne JP (1996) Extracutaneius manifestations of neutrophilic dermatosis (in French). Ann Dermatol Venereol 123:129–134

    CAS  PubMed  Google Scholar 

  • Ron et al. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20643691

  • Rosenbloom BE, Weinreb NJ (2013) Gaucher disease: a comprehensive review. Crit Rev Oncog 18:163–1975

    Article  PubMed  Google Scholar 

  • Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113:11–28

    Article  CAS  PubMed  Google Scholar 

  • Rull R, Grande L, Garcia-Valdecasas JC, Bombi JA, Alos LL, Fuster J, Lacy AM, Cugat E et al (1995) Malakoplakia in the gastrointestinal tract of a liver transplant recipient. Transplantation 59:1492–1494

    Article  CAS  PubMed  Google Scholar 

  • Sahel J, Scheiner C, Lebreuil G, Sarles H (1976) Malacoplasia of the cystic duct (in French). Arch Fr Mal App Dig 65:585–590

    CAS  PubMed  Google Scholar 

  • Sakakibara et al. 2002. http://www.ncbi.nlm.nih.gov/pubmed/12132528

  • Sampson et al. 1982. http://www.ncbi.nlm.nih.gov/pubmed/7183305

  • Schäfer A, Harzer K, Kattner E, Schafer HJ, Stoltenburg G, Lietz H (1996) Disseminated lipogranulomatosis (Farber disease) with hydrops fetalis (in German). Pathologe 17:145–149

    Article  PubMed  Google Scholar 

  • Scheuer PJ, Lefkowitch JH (2006) Liver biopsy interpretation, 7th edn. Elsevier Sanders, Philadelphia

    Google Scholar 

  • Schweiger S, Chaoui R, Tennstedt K, Mudlos S, Tinschert S (2003) Antenatal onset of cortical hyperostosis (Caffey disease): case report and review. Am J Med Genet 120A:547–552

    Article  PubMed  Google Scholar 

  • Smith B (1965) Malakoplakia of the urinary tract: a study of twenty-four cases. Am J Clin Pathol 43:409–417

    Article  CAS  PubMed  Google Scholar 

  • Smits JG, Kooijman CD (1986) Rheumatoid nodules in liver. Histopathology 10:1211–1213

    Article  CAS  PubMed  Google Scholar 

  • Stanton JM, Maxted W (1981) Malacoplakia: a study of the literature and current concepts of pathogenesis, diagnosis and treatment. J Urol 125:139–146

    CAS  PubMed  Google Scholar 

  • Stein P, Yu H, Jain D, Mistry PK (2010) Hyperferritinemia and iron overload in type 1 Gaucher disease. Am J Hematol 85:472–476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stenzel P, Weeks DA (2013) Abundant hepatic Gaucher-like cells following chemotherapy and bone marrow transplantation for hematologic malignancy: report of two cases. Int J Surg Pathol 21:89–92

    Article  PubMed  Google Scholar 

  • Stryker WA (1941) Absorption of liquid petrolatum (mineral oil) from the intestine: a histologic and chemical study. Arch Pathol Lab Med 29:691–699

    Google Scholar 

  • Sukov WR, Remstein ED, Nascimento AG, Sethi S, Lewin M (2009) Sclerosing extramedullary hematopoietic tumor: emphasis on diagnosis by renal biopsy. Ann Diagn Pathol 13:127–131

    Article  PubMed  Google Scholar 

  • Tai YS, Lin PW, Chen SG, Chang KC (1998) Inflammatory pseudotumor of the liver in a patient with human immunodeficiency virus infection. Hepatogastroenterology 45:1760–1763

    CAS  PubMed  Google Scholar 

  • Tamiolakis D, Ptassolopoulos P, Simopoulos C, Kotini A, Venizelos J, Alexiadis G, Manavis J, Papadopoulos N (2003) Renal extramedullary hematopoietic tumor diagnosed by fine needle aspiration: a case report. Acta Clin Belg 58:299–301

    Article  CAS  PubMed  Google Scholar 

  • Tamiolakis D, Venizelos J, Prassopoulos P, Simopoulos S, Bolioti S, Tsiapali M, Papadopoulos N (2004) Intrahepatic extramedullary hematopoietic tumor mimicking metastatic carcinoma from a colonic primary. Onkologie 27:65–67

    CAS  PubMed  Google Scholar 

  • Tamm EP, Rabushka LS, Fishman EK, Hruban RH, Diehl AM, Klein A (1995) Intrahepatic, extramedullary hematopoiesis mimicking hemangioma on technetium-99m red blood cell SPECT examination. Clin Imaging 19:88–91

    Article  CAS  PubMed  Google Scholar 

  • Tanino M, Ohta G (1981) An autopsy case of xanthogranuloma in the liver (in Japanese). Nippon Shokakibyo Zasshi 78:1803–1806

    CAS  Google Scholar 

  • Taylor JS, Lewis LA, Battle JD, Butkus A, Robertson AL, Deodhar S, Roenigk HH (1978) Plane xanthoma and multiple myeloma with lipoprotein-paraprotein complexing. Arch Dermatol 114:425–431

    Article  CAS  PubMed  Google Scholar 

  • Thannhauser SJ, Magendantz H (1938) The different clinical groups of xanthomatous diseases: a clinical physiological study of 22 cases. Ann Intern Med 11:1662–1746

    Article  CAS  Google Scholar 

  • Thinda S, Tomlinson JS (2009) Mesenteric rheumatoid nodules masquerading as an intraabdominal malignancy: a case report and review of the literature. World J Surg Oncol 7:59

    Article  PubMed  PubMed Central  Google Scholar 

  • Touton K (1885) Ueber das Xanthom, insbesondere dessen Histiologie und Histiogenese. Vierteljahrschr Dermatol Syph 12:3.53

    Article  Google Scholar 

  • Trivalle C, Profit P, Bonnet B, Manchon ND, Ducastelle T, Hemet J, Bercoff E, Bourreille J (1991) Liver lipogranulomas with long-term fever caused by paraffin oil (in French). Gastroenterol Clin Biol 15:551–553

    CAS  PubMed  Google Scholar 

  • Ung KA, Remotti H, Olsson R (2000) Eosinophilic hepatic necrosis in hypereosinophilic syndrome. J Clin Gastroenterol 31:323–327

    Article  CAS  PubMed  Google Scholar 

  • Urano S, Kodama H, Kato K, Nogura K (1995) Pyoderma gangrenosum with systemic involvement. J Dermatol 22:515–519

    Article  CAS  PubMed  Google Scholar 

  • Vadillo M, Jucgla A, Podzamczer D, Rufi G, Domingo A (1999) Pyoderma gangrenosum with liver, spleen and bone involvement in a patient with chronic myelomonocytic leukaemia. Br J Dermatol 141:541–543

    Article  CAS  PubMed  Google Scholar 

  • Valente AI, Pinto HC, Ramalho F, Cabrita PF, Catarino C, Serejo F, Baptista A, Saragoca A, Bordalo O, Moura MC (1997) Idiopathic hypereosinophilic syndrome presenting as cholestatic liver disease. Eur J Gastroenterol Hepatol 9:815–817

    Article  CAS  PubMed  Google Scholar 

  • Van Crevel R, Curfs J, van der Ven AJ, Assmann K, Meis JF, van der Meer JW (1998) Functional and morphological monocyte abnormalities in a patient with malakoplakia. Am J Med 105:74–77

    Article  PubMed  Google Scholar 

  • Verani R, Olson J, Moak JL (1980) Intrathoracic extramedullary hematopoiesis: report of a case in a patient with sickle-cell disease-beta-thalassemia. Am J Clin Pathol 73:133–137

    Article  CAS  PubMed  Google Scholar 

  • Verola O, de Roquancourt A, Chanu B, Rouffy J, Brocheriou C (1983) Hepatic cholesterolosis. Histological, histochemical and ultrastructural study of 2 cases (in French). Sem Hop 59:1753–1759

    CAS  PubMed  Google Scholar 

  • Vogt R (1998) Das Hieracium-Herbar von Karl Touton. Willdenowia 28:253–261

    Article  Google Scholar 

  • Von Hansemann D (1903) Ueber Malakoplakie der Harnblase. Virchows Arch Pathol Anat 173:302–308

    Article  Google Scholar 

  • Wanless IR, Geddie WR (1985) Mineral oil lipogranulomata in liver and spleen. A study of 465 autopsies. Arch Pathol Lab Med 109:283–286

    CAS  PubMed  Google Scholar 

  • Warshauer DM, Schiebler ML (1991) Intrahepatic extramedullary hematopoiesis: MR, CT and sonographic appearance. J Comput Assist Tomogr 15:683–685

    Article  CAS  PubMed  Google Scholar 

  • Wasserman SI, Goetzl EJ, Ellman L, Austen KF (1974) Tumor-associated eosinophilotactic factor. N Engl J Med 21:420–424

    Article  Google Scholar 

  • Weidman FD, Boston LN (1937) Generalized xanthoma tuberosum with xanthomatous changes in fresh scars of an intercurrent zoster. Arch Intern Med 59:793–822

    Article  Google Scholar 

  • Weidman FD, Freeman W (1924) Xanthoma tuberosum. Two necropsies disclosing lesions of the central nervous system and other tissues. Arch Derm Syphilol 9:149–175

    Article  Google Scholar 

  • Weidman FD, Stokes J (1937) Extensive xanthoma tuberosum in childhood due to infectious cirrhosis of the liver. Am J Dis Child 53:1230–1244

    Article  Google Scholar 

  • Weinrach DM, Wang KL, Cisler JJ, Diaz LK (2004) Pathologic quiz case: a 54-year-old liver transplant recipient with diffuse thickening of the sigmoid colon. Malakoplakia of the colon associated with liver transplant. Arch Pathol Lab Med 128:e133–e134

    PubMed  Google Scholar 

  • Wiener MD, Halvorsen RA, Vollmer RT, Foster WL, Roberts L (1987) Focal intrahepatic extramedullary hematopoiesis mimicking neoplasm. AJR Am J Roentgenol 149:1171–1172

    Article  CAS  PubMed  Google Scholar 

  • Willis A, Vanhuse C, Newton KP, Wasserstein M, Morotti RA (2008) Farber’s disease type IV presenting with cholestasis and neonatal liver failure: report of two cases. Pediatr Dev Pathol 11:305–308

    Article  PubMed  Google Scholar 

  • Wisnieski JJ, Askari AD (1981) Rheumatoid nodulosis. A relatively benign rheumatoid variant. Arch Intern Med 141:615–619

    Article  CAS  PubMed  Google Scholar 

  • Wollina U, Haroske G (2011) Pyoderma gangraenosum. Curr Opin Rheumatol 23:50–56

    Article  PubMed  Google Scholar 

  • Won JH, Kim BM, Ji H, Chung JJ, Yoo HS, Lee JT, Park YN, Hong SW (1999) Focal eosinophilic infiltration of the liver: a mimic of hepatic metastasis. Abdom Imaging 24:369–372

    Article  CAS  PubMed  Google Scholar 

  • Wong Y, Chen F, Tai KS, Yip LK, Tsang KW, Chan FL, Ooi GC (1999) Imaging features of focal intrahepatic extramedullary haematopoiesis. Br J Radiol 72:906–910

    Article  CAS  PubMed  Google Scholar 

  • Woollons A, Darley CR (1998) Xanthoma disseminatum: a case with hepatic involvement, diabetes insipidus and type IIb hyperlipidemia. Clin Exp Dermatol 23:277–280

    Article  CAS  PubMed  Google Scholar 

  • Wright JR, Van den Hof MC, Macken MB (2005) Prenatal infantile cortical hyperostosis (Caffey’s disease): a ‘hepatic myeloid hyperplasia-pulmonary hypoplasia sequence’ can explain the lethality of early onset cases. Prenat Diagn 25:939–944

    Article  PubMed  Google Scholar 

  • Xu R, Mistry P, McKenna G, Emre S, Schiano T, Bu-Ghanim M, Levi G, Fiel MI (2005) Hepatocellular carcinoma in type 1 Gaucher disease: a case report with review of the literature. Semin Liver Dis 25:226–229

    Article  PubMed  Google Scholar 

  • Yang X, Bhuiya T, Esposito M (2002) Sclerosing extramedullary hematopoietic tumor. Ann Diagn Pathol 6:183–187

    Article  PubMed  Google Scholar 

  • Yang T, Zhang BH, Zhang J, Zhang YJ, Jiang XQ, Wu MC (2007) Surgical treatment of xanthogranulomatous cholecystitis: experience in 33 cases. Hepatobiliary Pancreat Dis Int 6:504–508

    PubMed  Google Scholar 

  • Yim H, Ahn HJ, Park C, Cheon JY (1995) Xanthoma of the liver in a patient with multiple myeloma associated with hyperlipidemia. A case report. J Korean Med Sci 10:453–456

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoo SY, Han JK, Kim YH, Kim TK, Choi BI, Han MC (2003) Focal eosinophilic infiltration in the liver: radiologic findings and clinical course. Abdom Imaging 28:326–332

    Article  CAS  PubMed  Google Scholar 

  • Yoon KH, Ha HK, Lee JS, Suh JH, Kim MH, Kim PN, Lee MG, Yun KJ, Choi SC, Nah YH, Kim CG, Won JJ, Auh YH (1999) Inflammatory pseudotumor of the liver in patients with recurrent pyogenic cholangitis: CT-histopathologic correlation. Radiology 211:373–379

    Article  CAS  PubMed  Google Scholar 

  • Yoshida T, Nishimori I, Kumon M, Kohsaki T, Taniuchi K, Ohtsuki Y, Onishi S (2003) Inflammatory pseudotumor of the liver: report of a case diagnosed by needle biopsy. Hepatol Res 27:83–86

    Article  PubMed  Google Scholar 

  • Yousef GM, Naghibi B (2007) Malakoplakia outside the urinary tract. Arch Pathol Lab Med 131:297–300

    PubMed  Google Scholar 

  • Yu JS, Yoon SW, Park MS, Lee JH, Kim KW (2005) Eosinophilic hepatic necrosis: magnetic resonance imaging and computed tomography comparison. J Comput Assist Tomogr 29:765–771

    Article  PubMed  Google Scholar 

  • Yuoh G, Hove MG, Wen J, Haque AK (1996) Pulmonary malakoplakia in acquired immunodeficiency syndrome: an ultrastructural study of morphogenesis of Michaelis-Gutmann bodies. Mod Pathol 9:476–483

    CAS  PubMed  Google Scholar 

  • Zeek PM (1952) Periarteritis nodosa: a critical review. Am J Clin Pathol 22:777–790

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z, Mandal AK, Mital A, Popescu N, Zimonjic D, Moser A, Moser H, Mukherjee AB (2000) Human acid ceramidase gene: novel mutations in Farber disease. Mol Genet Metab 70:301–309

    Article  CAS  PubMed  Google Scholar 

  • Zhou et al. 1992. http://www.ncbi.nlm.nih.gov/pubmed/1464731

  • Zhu H, Bodenheimer HC, Clain DJ, Min AD, Theise ND (2010) Hepatic lipogranulomas in patients with chronic liver disease: association with hepatitis C and fatty liver disease. World J Gastroenterol 16:5065–5069

    Article  PubMed  PubMed Central  Google Scholar 

  • Ziff M (1990) The rheumatoid nodule. Arthritis Rheum 33:761–767

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

Authors
  1. Arthur Zimmermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arthur Zimmermann .

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this entry

Cite this entry

Zimmermann, A. (2016). Hepatobiliary Pseudotumors Consisting of Nonneoplastic Hematopoietic Cells and Cells of the Macrophage Lineage. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26587-2_125-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26587-2_125-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-26587-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation