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Nuclear Oncology pp 1–30Cite as

Radioguided Surgery: Novel Applications

Abstract

A few years ago, the concept of Guided intraOperative Scintigraphic Tumor Targeting (GOSTT) was introduced to encompass the whole spectrum of basic and advanced nuclear medicine procedures required for providing a roadmap for radioguided surgery. This concept included the use of interventional nuclear medicine imaging to depict targets to be resected by radioguided surgery. With the incorporation of SPECT/CT and PET/CT, three-dimensional roadmaps to guide surgical procedures became possible. On the other side, new intraoperative portable imaging devices (gamma cameras and other tools) were added to conventional modalities such as gamma probes and blue dye. More recently, the development of hybrid tracers integrating radioactivity and fluorescence in one single signature has enabled the additional use of near-infrared cameras. All these advances have facilitated the extension of radioguided sentinel lymph node biopsy procedures from the classical applications in cutaneous melanoma and breast cancer to other fields such as oral cavity, gastrointestinal, urological, and gynecological malignancies. At present, three GOSTT working models can be defined in relation to radiotracer administration: intralesional without tracer migration for occult lesion localization, intralesional with tracer migration for occult lesion localization and sentinel lymph node biopsy, and systemic to enable excisional biopsy of primary lesions and recurrences as well as isolated regional and distant metastases. The latter is probably the field with the largest potential due to the continuous introduction of new PET and SPECT tracers. Novel modalities like luminescence detection and tracked image-guided navigation will further reinforce the role of GOSTT and radioguided intervention procedures.

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Abbreviations

[18F]FDG:

2-Deoxy-2-[18F]fluoro-d-glucose

99mTc-MAA:

99mTc-macroaggregated albumin

AJCC:

American Joint Committee on Cancer

CT:

X-ray computed tomography

GOSTT:

Guided intraOperative Scintigraphic Tumor Targeting

ICG:

Indocyanine green

M:

Metastasis status according to the AJCC/UICC TNM staging system

MEN:

Multiple endocrine neoplasm

MIBG:

meta-Iodobenzylguanidine

MIP:

Maximum intensity projection

MPR:

Multiplanar reconstruction

N:

Lymph node status according to the AJCC/UICC TNM staging system

NET:

Neuroendocrine tumor

NIR:

Near-infrared

PET:

Positron emission tomography

PET/CT:

Positron emission tomography/Computed tomography

PSMA:

Prostate-specific membrane antigen

ROLL:

Radioguided occult lesion localization

RSL:

Radioguided 125I seed localization

SLN:

Sentinel lymph node

SNOLL:

Combined sentinel lymph node biopsy and radioguided occult lesion localization

SPECT:

Single-photon emission computed tomography

SPECT/CT:

Single photon emission computed tomography/Computed tomography

T:

Tumor status according to the AJCC/UICC TNM staging system

UICC:

Union Internationale Contre le Cancer (International Union Against Cancer)

References

  1. Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery – a comprehensive team approach. New York: Springer; 2008.

    Google Scholar 

  2. Zaknun JJ, Giammarile F, Valdés Olmos RA, Vidal-Sicart S, Mariani G. Changing in radioguided surgery and intraoperative imaging: the GOSTT concept. Eur J Nucl Med Mol Imaging. 2012;39:1–3.

    Article  PubMed  Google Scholar 

  3. Valdés Olmos RA, Vidal-Sicart S, Giammarile F, Zaknun JJ, van Leeuwen FWB, Mariani G. The GOSTT concept and hybrid mixed/virtual/augmented reality environment radioguided surgery. Q J Nucl Med Mol Imaging. 2014;58:207–15.

    PubMed  Google Scholar 

  4. International Atomic Energy Agency (IAEA), editor. Guided Intraoperative Scintigraphic Tumour Targeting (GOSTT): implementing advanced hybrid molecular imaging and non-imaging probes for advanced cancer management. Vienna: IAEA; 2014.

    Google Scholar 

  5. Cabañas RM. An approach for the treatment of penile carcinoma. Cancer. 1977;39:456–66.

    Article  PubMed  Google Scholar 

  6. Boni G, Manca G, Melfi FMA, Lucchi M, Mussi A, Mariani G. Sentinel lymph node biopsy in non-small-cell lung cancer. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery: a comprehensive team approach. New York: Springer; 2008. p. 166–71.

    Chapter  Google Scholar 

  7. Kitagawa Y, Saha S, Kitajima M. Sentinel lymph node biopsy in cancers of the gastrointestinal tract. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery – a comprehensive team approach. New York: Springer; 2008. p. 148–56.

    Google Scholar 

  8. Levenback CF. Status of sentinel lymph node biopsy in gynecological cancers. Ann Surg Oncol. 2008;15:18–20.

    Article  PubMed  Google Scholar 

  9. Sugi K, Kobayashi S, Yagi R, Matsuoka T. Usefulness of sentinel lymph node biopsy for the detection of lymph node micrometastasis in early lung cancer. Interact Cardiovasc Thorac Surg. 2008;7:913–5.

    Article  PubMed  Google Scholar 

  10. Anand SM, Gologan O, Rochon L, Tamilia M, How J, Hier MP, Black MJ, et al. The role of sentinel lymph node biopsy in differentiated thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2009;135:1199–204.

    Article  PubMed  Google Scholar 

  11. Dragan R, Nebojsa M, Dejan S, Ivan P, Dragos S, Damir J, Predrag S, Vladan Z. Clinical application of sentinel lymph node biopsy for staging, treatment and prognosis of colon and gastric cancer. Hepatogastroenterology. 2009;56:1606–11.

    PubMed  Google Scholar 

  12. Holl G, Dorn R, Wengenmair H, Weckermann D, Sciuk J. Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients. Eur J Nucl Med Mol Imaging. 2009;36:1377–82.

    Article  CAS  PubMed  Google Scholar 

  13. Mistrangelo M, Morino M. Sentinel lymph node biopsy in anal cancer: a review. Gastroenterol Clin Biol. 2009;33:446–50.

    Article  CAS  PubMed  Google Scholar 

  14. Sloan P. Head and neck sentinel lymph node biopsy: current state of the art. Head Neck Pathol. 2009;3:231–7.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Thompson R, Hunter KD, et al. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European multicenter trial. Ann Surg Oncol. 2010;17:2459–64.

    Article  PubMed  Google Scholar 

  16. Paganelli G, De Cicco C, Gatti G, Luini A. Radioguided occult lesion localization in the breast. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery – a comprehensive team approach. New York: Springer; 2008. p. 81–91.

    Google Scholar 

  17. Boni G, Melfi FMA, Manca G, Lucchi M, Mussi A, Mariani G. Radioguided surgery of solitary pulmonary lesions. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery: a comprehensive team approach. New York: Springer; 2008. p. 262–8.

    Chapter  Google Scholar 

  18. Feggi Feggi L, Basaglia E, Corcione S, Querzoli P, Soliani G, Ascanelli S, Prandini N, Bergossi L, Carcoforo P. An original approach in the diagnosis of early breast cancer: use of the same radiopharmaceutical for both non-palpable lesions and sentinel node localisation. Eur J Nucl Med. 2001;28:1589–96.

    Article  PubMed  CAS  Google Scholar 

  19. van Rijk MC, Tanis PJ, Nieweg OE, Loo CE, Valdés Olmos RA, Oldenburg HS, Rutgers EJ, Hoefnagel CA, Kroon BB. Sentinel node biopsy and concomitant probe-guided tumor excision of nonpalpable breast cancer. Ann Surg Oncol. 2007;14:627–32.

    Article  PubMed  Google Scholar 

  20. Strong VE, Humm J, Russo P, Jungbluth A, Wong WD, Daghighian F, Old L, Fong Y, Larson SM. A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes. Surg Endosc. 2008;22:386–91.

    Article  PubMed  Google Scholar 

  21. Thorek DL, Riedl CC, Grimm J. Clinical Cerenkov luminescence imaging of 18F-FDG. J Nucl Med. 2014;55:95–8.

    Article  CAS  PubMed  Google Scholar 

  22. Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127:392–9.

    Article  CAS  PubMed  Google Scholar 

  23. Nieweg OE, Tanis PJ, Kroon BB. The definition of a sentinel node. Ann Surg Oncol. 2001;8:538–41.

    Article  CAS  PubMed  Google Scholar 

  24. Valdés Olmos RA, Hoefnagel CA, Nieweg OE, Jansen L, Rutgers EJ, Border J, et al. Lymphoscintigraphy in oncology: a rediscovered challenge. Eur J Nucl Med. 1999;26:S2–10.

    Article  PubMed  Google Scholar 

  25. Orsini F, Guidoccio F, Vidal-Sicart S, Valdés Olmos RA, Mariani G. General concepts on radioguided sentinel lymph node biopsy: preoperative imaging, intraoperative gamma-probe guidance, intraoperative imaging, and multimodality imaging. In: Mariani G, Manca G, Orsini F, Vidal-Sicart S, Valdés Olmos RA, editors. Atlas of lymphoscintigraphy and sentinel node mapping. Milan: Springer; 2013. p. 95–110.

    Chapter  Google Scholar 

  26. Nieweg OE. The sentinel lymph node concept in oncologic surgery. In: Mariani G, Manca G, Orsini F, Vidal-Sicart S, Valdés Olmos RA, editors. Atlas of lymphoscintigraphy and sentinel node mapping. Milan: Springer; 2013. p. 87–93.

    Chapter  Google Scholar 

  27. Krag DN, Weaver DL, Alex JC, Fairbank JT. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol. 1993;2:335–9.

    Article  CAS  PubMed  Google Scholar 

  28. Valdés Olmos RA, Vidal-Sicart S, Nieweg OE. SPECT-CT and real-time intraoperative imaging: new tools for sentinel node localization and radioguided surgery. Eur J Nucl Med Mol Imaging. 2009;36:1–5.

    Article  Google Scholar 

  29. Valdés Olmos RA, Vidal-Sicart S, Nieweg OE. Technological innovation in the sentinel node procedure: towards 3-D intraoperative imaging. Eur J Nucl Med Mol Imaging. 2010;37:1449–51.

    Article  PubMed  Google Scholar 

  30. Vidal-Sicart S, van Leeuwen FW, van den Berg NS, Valdés Olmos RA. Fluorescent radiocolloids: are hybrid tracers the future for lymphatic mapping? Eur J Nucl Med Mol Imaging. 2015;42:1627–30.

    Article  PubMed  Google Scholar 

  31. Kapteijn BAE, Nieweg OE, Valdés Olmos RA, Liem IH, Panday RKLB, Hoefnagel CA, et al. Reproducibility of lymphoscintigraphy for lymphatic mapping in cutaneous melanoma. J Nucl Med. 1996;37:972–5.

    CAS  PubMed  Google Scholar 

  32. Vidal M, Vidal-Sicart S, Torrents A, Perissinotti A, Navales I, Paredes P, et al. Accuracy and reproducibility of lymphoscintigraphy for sentinel node detection in patients with cutaneous melanoma. J Nucl Med. 2012;53:1193–9.

    Article  PubMed  Google Scholar 

  33. Tanis PJ, Valdés Olmos RA, Muller SH, Nieweg OE. Lymphatic mapping in patients with breast carcinoma: reproducibility of lymphoscintigraphic results. Radiology. 2003;228:546–51.

    Article  PubMed  Google Scholar 

  34. Kroon BK, Valdés Olmos RA, Nieweg OE, Horenblas S. Reproducibility of lymphoscintigraphy for lymphatic mapping in patients with penile carcinoma. J Urol. 2005;174:2214–7.

    Article  PubMed  Google Scholar 

  35. Valdés Olmos RA, Vidal-Sicart S, Rietbergen DDD. SPECT/CT and sentinel node lymphoscintigraphy. Clin Transl Imaging. 2014;2:491–504.

    Article  Google Scholar 

  36. Lerman H, Metser U, Lievshitz G, Sperber F, Shneebaum S, Even-Sapir E. Lymphoscintigraphic sentinel node identification in patients with breast cancer: the role of SPECTCT. Eur J Nucl Med Mol Imaging. 2006;33:329–37.

    Article  CAS  PubMed  Google Scholar 

  37. Mariani G, Bruselli L, Kuwert T, Kim EE, Flotats A, Israel O, Dondi M, Watanabe N. A review on the clinical uses of SPECT/CT. Eur J Nucl Med Mol Imaging. 2010;37:1959–85.

    Article  PubMed  Google Scholar 

  38. Vermeeren L, van der Ploeg IM, Valdés Olmos RA, Meinhardt W, Klop WM, Kroon BB, Nieweg OE. SPECT/CT for preoperative sentinel node localization. J Surg Oncol. 2010;101:184–90.

    PubMed  Google Scholar 

  39. Kobayashi K, Ramirez PT, Kim EE, et al. Sentinel node mapping in vulvovaginal melanoma using SPECT/CT lymphoscintigraphy. Clin Nucl Med. 2009;34:859–61.

    Article  PubMed  Google Scholar 

  40. Leijte JA, van der Ploeg IM, Valdés Olmos RA, Nieweg OE, Horenblas S. Visualization of tumor blockage and rerouting of lymphatic drainage in penile cancer patients by use of SPECT/CT. J Nucl Med. 2009;50:364–7.

    Article  PubMed  Google Scholar 

  41. van der Ploeg IM, Valdés Olmos RA, Kroon BB, et al. The yield of SPECT/CT for anatomical lymphatic mapping in patients with melanoma. Ann Surg Oncol. 2009;16:1537–42.

    Article  PubMed  Google Scholar 

  42. Sieira-Gil R, Paredes P, Martí-Pagès C, Ferrer-Fuertes A, García-Díez E, Cho-Lee GY, et al. SPECT-CT and intraoperative portable gamma-camera detection protocol for sentinel lymph node biopsy in oral cavity squamous cell carcinoma. J Craniomaxillofac Surg. 2015;43:2205–13.

    Article  PubMed  Google Scholar 

  43. Vermeeren L, Valdés Olmos RA, Meinhardt W, et al. Value of SPECT/CT for detection and anatomic localization of sentinel lymph nodes before laparoscopic sentinel node lymphadenectomy in prostate carcinoma. J Nucl Med. 2009;50:865–70.

    Article  PubMed  Google Scholar 

  44. Pandit-Taskar N, Gemignani ML, Lyall A, Larson SM, Barakat RR, Abu Rustum NR. Single photon emission computed tomography SPECT-CT improves sentinel node detection and localization in cervical and uterine malignancy. Gynecol Oncol. 2010;117:59–64.

    Article  PubMed  Google Scholar 

  45. Vermeeren L, Meinhardt W, Valdes Olmos RA. Prostatic lymphatic drainage with sentinel nodes at the ventral abdominal wall visualized with SPECT/CT: a case series. Clin Nucl Med. 2010;35:71–3.

    Article  PubMed  Google Scholar 

  46. Vermeeren L, Valdés Olmos RA, Klop WM, van der Ploeg IM, Nieweg OE, Balm AJ, van den Brekel MW. SPECT/CT for sentinel lymph node mapping in head and neck melanoma. Head Neck. 2011;33:1–6.

    Article  PubMed  Google Scholar 

  47. Valdés Olmos RA, Vidal-Sicart S. SPECT/CT image generation and criteria for sentinel node imaging. In: Mariani G, Manca G, Orsini F, Vidal-Sicart S, Valdés Olmos RA, editors. Atlas of lymphoscintigraphy and sentinel node mapping. Milan: Springer; 2013. p. 111–9.

    Chapter  Google Scholar 

  48. Goldstein RE, Billheimer D, Martin WH, Richards K. Sestamibi scanning and minimally invasive radioguided parathyroidectomy without intraoperative parathyroid hormone measurement. Ann Surg. 2003;237:722–31.

    PubMed  PubMed Central  Google Scholar 

  49. Shafiei B, Hoseinzadeh S, Fotouhi F, Malek H, Azizi F, Jahed A, et al. Preoperative 99mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism and concomitant nodular goiter: comparison of SPECT-CT, SPECT, and planar imaging. Nucl Med Commun. 2012;33:1070–6.

    Article  CAS  PubMed  Google Scholar 

  50. Mariani G, Moresco L, Viale G, Villa G, Bagnasco M, Canavese G, Buscombe J, Strauss HW, Paganelli G. Radioguided sentinel lymph node biopsy in breast cancer surgery. J Nucl Med. 2001;42:1198–215.

    CAS  PubMed  Google Scholar 

  51. Obenaus E, Erba PA, Chinol M, Van de Wiele C, Janoki GA, Dierckx RA, Scopinaro F, Signore A. Radiopharmaceuticals for radioguided surgery. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery – a comprehensive team approach. New York: Springer; 2008. p. 3–11.

    Google Scholar 

  52. Vera DR, Wallace AM, Hoh CK, Mattrey RF. A synthetic macromolecule for sentinel node detection: 99mTc-DTPA-mannosyl-dextran. J Nucl Med. 2001;42:951–9.

    CAS  PubMed  Google Scholar 

  53. Marcinow AM, Hall N, Byrum E, Teknos TN, Old MO, Agrawal A. Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study. JAMA Otolaryngol Head Neck Surg. 2013;139:895–902.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Sondak VK, King DW, Zager JS, Schneebaum S, Kim J, Leong SP, et al. Combined analysis of phase III trials evaluating [99mTc]tilmanocept and vital blue dye for identification of sentinel lymph node(s) in clinically node-negative cutaneous melanoma. Ann Surg Oncol. 2013;20:680–8.

    Article  PubMed  Google Scholar 

  55. Wallace AM, Han LK, Povoski SP, Deck K, Schneebaum S, Hall NC, et al. Comparative evaluation of [99mTc]-tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials. Ann Surg Oncol. 2013;20:2590–9.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Brouwer OR, Vermeeren L, Klop WMC, Balm AJM, van der Poel HG, van Rhijn BW, et al. Comparing the hybrid fluorescent-radioactive tracer indocyanine green-99mTc-nanocolloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT/CT. J Nucl Med. 2012;53:1034–40.

    Article  CAS  PubMed  Google Scholar 

  57. Van den Berg NS, Brouwer OR, Klop WMC, Karakulluckcu B, Zuur CL, Tan IB, et al. Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-99mTc-nanocolloid. Eur J Nucl Med Mol Imaging. 2012;39:1128–36.

    Article  CAS  PubMed  Google Scholar 

  58. Mathéron HM, van den Berg NS, Brouwer OR, Kleinjan GH, van Driel WJ, Trum JW, Vegt E, Kenter G, van Leeuwen FW, Valdés Olmos RA. Multimodal surgical guidance towards the sentinel node in vulvar cancer. Gynecol Oncol. 2013;131:720–5.

    Article  PubMed  Google Scholar 

  59. Brouwer OR, van den Berg NS, Mathéron HM, van der Poel HG, van Rhijn BW, Bex A, et al. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. Eur Urol. 2014;65:600–9.

    Article  CAS  PubMed  Google Scholar 

  60. Kleinjan GH, van den Berg NS, Brouwer OR, de Jong J, Acar C, Wit EM, et al. Optimisation of fluorescence guidance during robot-assisted laparoscopic sentinel node biopsy for prostate cancer. Eur Urol. 2014;66:991–8.

    Article  PubMed  Google Scholar 

  61. van den Berg NS, Brouwer OR, Schaafsma BE, Mathéron HM, Klop WM, Balm AJ, et al. Multimodal surgical guidance during sentinel node biopsy for melanoma: combined gamma tracing and fluorescence imaging of the sentinel node through use of the hybrid tracer indocyanine green-99mTc-nanocolloid. Radiology. 2015;275:521–9.

    Article  PubMed  Google Scholar 

  62. De Cicco C, Pizzamiglio M, Trifirò G, Luini A, Ferrari M, Prisco G, et al. Radioguided occult lesion localisation (ROLL) and surgical biopsy in breast cancer. Technical aspects. Q J Nucl Med. 2002;46:145–51.

    PubMed  Google Scholar 

  63. Gallegos Hernandez JF, Tanis PJ, Deurloo EE, Nieweg OE, Th Rutgers EJ, Kroon BB, Valdés Olmos RA. Radio-guided surgery improves outcome of therapeutic excision in non-palpable invasive breast cancer. Nucl Med Commun. 2004;25:227–32.

    Article  CAS  PubMed  Google Scholar 

  64. Gray RJ, Salud C, Nguyen K, Dauway E, Friedland J, Berman C, Peltz E, Whitehead G, Cox CE. Randomized prospective evaluation of a novel technique for biopsy or lumpectomy of nonpalpable breast lesions: radioactive seed versus wire localization. Ann Surg Oncol. 2001;8:711–5.

    Article  CAS  PubMed  Google Scholar 

  65. Van der Noordaa ME, Pengel KE, Groen E, van Werkhoven E, Rutgers EJ, Loo CE, et al. The use of radioactive iodine-125 seed localization in patients with non-palpable breast cancer: a comparison with the radioguided occult lesion localization with 99m technetium. Eur J Surg Oncol. 2015;41:553–8.

    Article  PubMed  Google Scholar 

  66. Donker M, Drukker CA, Valdés Olmos RA, Rutgers EJ, Loo CE, Sonke GS, et al. Guiding breast-conserving surgery in patients after neoadjuvant systemic therapy for breast cancer: a comparison of radioactive seed localization with the ROLL technique. Ann Surg Oncol. 2013;20:2569–75.

    Article  PubMed  Google Scholar 

  67. Giles YŞ, Sarıcı IS, Tunca F, Sormaz IC, Salmaslıoğlu A, Adalet I, et al. The rate of operative success achieved with radioguided occult lesion localization and intraoperative ultrasonography in patients with recurrent papillary thyroid cancer. Surgery. 2014;156:1116–26.

    Article  PubMed  Google Scholar 

  68. Aydogan F, Ozben V, Atasoy D, Yilmaz MH, Halaç M, Celik V. Excision of axillary lymph node recurrences in breast cancer patients with axillary ROLL (A-ROLL). J Surg Oncol. 2010;101:141–4.

    PubMed  Google Scholar 

  69. Donker M, Straver ME, Wesseling J, Loo CE, Schot M, Drukker CA, et al. Marking axillary lymph nodes with radioactive iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI procedure. Ann Surg. 2015;261:378–82.

    Article  PubMed  Google Scholar 

  70. Jansen L, Nieweg OE, Valdés Olmos RA, Rutgers EJ, Peterse JL, de Vries J, et al. Improved staging of breast cancer through lymphatic mapping and sentinel node biopsy. Eur J Surg Oncol. 1998;24:445–6.

    Article  CAS  PubMed  Google Scholar 

  71. Povoski SP, Hall NC, Murrey Jr DA, Wright CL, Martin Jr EW. Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma. BMC Cancer. 2015;15:378.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  72. Molina MA, Goodwin WJ, Moffat FL, Serafini AN, Sfakianakis GN, Avisar E. Intra-operative use of PET probe for localization of FDG avid lesions. Cancer Imaging. 2009;9:59–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Wang YZ, Diebold A, Woltering E, King H, Boudreaux JP, Anthony LB, et al. Radioguided exploration facilitates surgical cytoreduction of neuroendocrine tumors. J Gastrointest Surg. 2012;16:635–40.

    Article  PubMed  Google Scholar 

  74. Van Hulsteijn LT, Corssmit EPM, van der Hiel B, Smit JWA, Stokkel MP. Is there a role for radioguided surgery with iodine-labeled metaiodobenzylguanidine in resection of neuroendocrine tumors? Clin Nucl Med. 2012;37:1083–8.

    Article  PubMed  Google Scholar 

  75. Castaldi P, Rufini V, Treglia G, Bruno I, Perotti G, Stifano G, et al. Impact of 111In-DTPA-octreotide SPECT/CT fusion in the management of neuroendocrine tumours. Radiol Med. 2008;113:1056–67.

    Article  CAS  PubMed  Google Scholar 

  76. Kaemmerer D, Prasad V, Daffner W, Haugvik SP, Senftleben S, Baum RP, et al. Radioguided surgery in neuroendocrine tumors using Ga-68-labeled analogs: a pilot study. Clin Nucl Med. 2012;37:142–7.

    Article  PubMed  Google Scholar 

  77. Delbeke D, Coleman RE, Guiberteau MJ, Brown ML, Royal HD, Siegel BA, et al. Procedure guidelines for SPECT/CT imaging. J Nucl Med. 2006;47:1227–34.

    PubMed  Google Scholar 

  78. Fishman EK, Ney DR, Heath DG, Corl FM, Horton KM, Johnson PT. Volume rendering versus maximum intensity projection in CT angiography: what works best, when, and why. Radiographics. 2006;26:905–22.

    Article  PubMed  Google Scholar 

  79. Vidal-Sicart S, Paredes P, Zanón G, Pahisa J, Martinez-Román S, Caparrós X, et al. Added value of intraoperative real-time imaging in searches for difficult-to-locate sentinel nodes. J Nucl Med. 2010;51:1219–25.

    Article  PubMed  Google Scholar 

  80. Fuster D, Vidal-Sicart S, Torregrosa JV, Paredes P, Rubello D, Pons F. What is the role of preoperative scintigraphic imaging and the intraoperative gamma probe in secondary hyperparathyroidism? Nucl Med Commun. 2014;35:443–5.

    Article  PubMed  Google Scholar 

  81. Hellingman D, de Wit-van der Veen LJ, Klop WM, Valdés Olmos RA. Detecting near-the-injection-site sentinel nodes in head and neck melanomas with a high-resolution portable gamma camera. Clin Nucl Med. 2015;40:e11–6.

    Article  PubMed  Google Scholar 

  82. Hellingman D, Vidal-Sicart S, de Wit-van der Veen LJ, Paredes P, Valdés Olmos RA. Clin Nucl Med. 2016;41:e39–43.

    Article  PubMed  Google Scholar 

  83. Lees JE, Bugby SL, Bhatia BS, Jambi LK, Alqahtani MS, McKnight WR, et al. A small field of view camera for hybrid gamma and optical imaging. J Instrum. 2014;9:C12020.

    Article  Google Scholar 

  84. Wendler T, Herrmann K, Schnelzer A, Lasser T, Traub J, Kutter O, et al. First demonstration of 3-D lymphatic mapping in breast cancer using freehand SPECT. Eur J Nucl Med Mol Imaging. 2010;37:1452–61.

    Article  PubMed  Google Scholar 

  85. Bluemel C, Schnelzer A, Okur A, Ehlerding A, Paepke S, Scheidhauer K, et al. Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer. Eur J Nucl Med Mol Imaging. 2013;40:1656–61.

    Article  PubMed  Google Scholar 

  86. Bluemel C, Herrmann K, Müller-Richter U, Lapa C, Higuchi T, Wild V, Buck AK, Kübler A, Linz C. Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma. Head Neck. 2014;36:e112–6.

    Article  PubMed  Google Scholar 

  87. Mihaljevic AL, Rieger A, Belloni B, Hein R, Okur A, Scheidhauer K, Schuster T, Friess H, Martignoni ME. Transferring innovative freehand SPECT to the operating room: first experiences with sentinel lymph node biopsy in malignant melanoma. Eur J Surg Oncol. 2014;40:42–8.

    Article  CAS  PubMed  Google Scholar 

  88. Rahbar K, Colombo-Benkmann M, Haane C, Wenning C, Vrachimis A, Weckesser, et al. Intraoperative 3-D mapping of parathyroid adenoma using freehand SPECT. EJNMMI Res. 2012;2:51.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Milgram P, Kishino F. A taxonomy of mixed reality visual displays. IEICE transactions of information and systems. The institute of electronics. Inf Commun Eng. 1994;E77-D:1321–9.

    Google Scholar 

  90. Brouwer OR, Buckle T, Bunschoten A, Vahrmeijer A, Wendler T, Valdés Olmos RA, et al. Image navigation as a means to expand the boundaries of fluorescence guided surgery. Phys Med Biol. 2012;57:3123–36.

    Article  PubMed  Google Scholar 

  91. Brouwer OR, van den Berg NS, Mathéron HM, Wendler T, van der Poel HG, Horenblas S, et al. Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired single photon emission computerized tomography data: transferring functional imaging to the operating room. J Urol. 2014;192:1810–6.

    Article  PubMed  Google Scholar 

  92. Engelen T, Winkel BM, Rietbergen DD, KleinJan GH, Vidal-Sicart S, Valdés Olmos RA, et al. The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehand SPECT-mobile gamma camera combination. Am J Nucl Med Mol Imaging. 2015;5:233–45.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Pouw B, de Wit-van der Veen LJ, van Duijnhoven F, Rutgers EJ, Stokkel MP, Valdés Olmos RA, et al. Intraoperative 3D navigation for single or multiple 125I-seed localization in breast-preserving cancer surgery. Clin Nucl Med. 2016;41:e216–20.

    Article  PubMed  Google Scholar 

  94. Bluemel C, Cramer A, Grossmann C, Kajdi GW, Malzahn U, Lamp N, et al. iROLL: does 3-D radioguided occult lesion localization improve surgical management in early-stage breast cancer? Eur J Nucl Med Mol Imaging. 2015;42:1692–9.

    Article  CAS  PubMed  Google Scholar 

  95. American Joint Committee on Cancer. Cancer staging handbook. 7th ed. New York: Springer; 2010.

    Book  Google Scholar 

  96. Civantos FJ, Zitsch RP, Schuller DE, Agrawal A, Smith RB, Nason R, et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol. 2010;28:1395–400.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, et al. Lymphatic drainage patterns in oral squamous cell carcinoma: findings of the ACOSOG Z0360 (Alliance) study. Otolaryngol Head Neck Surg. 2015;152:673–7.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Haerle SK, Hany TF, Strobel K, Sidler D, Stoeckli SJ. Is there an additional value of SPECT/CT over planar lymphoscintigraphy for sentinel node mapping in oral/oropharyngeal squamous cell carcinoma? Ann Surg Oncol. 2009;16:3118–24.

    Article  PubMed  Google Scholar 

  99. Bilde A, Von Buchwald C, Mortensen J, Marving J, Hamilton Therkildsen M, Kirkegaard J, et al. The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer. Acta Otolaryngol. 2006;126:1096–103.

    Article  PubMed  Google Scholar 

  100. Klode J, Poeppel T, Boy C, Mueller S, Schadendorf D, Korber A, et al. Advantages of preoperative hybrid SPECT/CT in detection of sentinel lymph nodes in cutaneous head and neck malignancies. J Eur Acad Dermatol Venereol. 2011;25:1213–21.

    Article  CAS  PubMed  Google Scholar 

  101. Zender C, Guo T, Weng C, Faulhaber P, Rezaee R. Utility of SPECT/CT for periparotid sentinel lymph node mapping in the surgical management of head and neck melanoma. Am J Otolaryngol Head Neck Med Surg. 2014;35:12–8.

    Google Scholar 

  102. López-Rodríguez E, García-Gómez FJ, Álvarez-Pérez RM, Martínez-Castillo R, Borrego-Dorado I, Fernández-Ortega P, et al. Role of SPECT-CT in sentinel lymph node biopsy in patients diagnosed with head and neck melanoma. Rev Esp Med Nucl Imagen Mol. 2016;35:22–8.

    PubMed  Google Scholar 

  103. Daisne JF, Installé J, Bihin B, Laloux M, Vander Borght T, Mathieu I, Lawson G. SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: a prospective phase I feasibility study. Radiat Oncol. 2014;9:121.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Borbón-Arce M, Brouwer OR, van den Berg NS, Mathéron H, Klop WM, Balm AJ, et al. An innovative multimodality approach for sentinel node mapping and biopsy in head and neck malignancies. Rev Esp Med Nucl Imagen Mol. 2014;33:274–9.

    PubMed  Google Scholar 

  105. Garcia-Burillo A, Roca Bielsa I, Gonzalez O, Zafon C, Sabate M, Castellvi J, et al. SPECT/CT sentinel lymph node identification in papillary thyroid cancer: lymphatic staging and surgical management improvement. Eur J Nucl Med Mol Imaging. 2013;40:1645–55.

    Article  CAS  PubMed  Google Scholar 

  106. Cabrera RN, Chone CT, Zantut-Wittmann D, Matos P, Ferreira DM, Pereira PSG, et al. Value of sentinel lymph node biopsy in papillary thyroid cancer: initial results of a prospective trial. Eur Arch Otorhinolaryngol. 2015;272:971–9.

    Article  CAS  PubMed  Google Scholar 

  107. Francis CL, Nailey C, Fan C, Bodenner D, Stack BC. 18F-fluorodeoxyglucose and 131I radioguided surgical management of thyroid cancer. Otolaryngol Head Neck Surg. 2012;146:26–32.

    Article  PubMed  Google Scholar 

  108. Dubach P, Oliveira-Santos T, Weber S, Gerber N, Dietz A, Caversaccio M. 18 FDG-PET/CT computer-assisted biopsies for suspected persistent or recurrent malignant skull base disease. Head Neck. 2014. doi:10.1002/hed.23756. [Epub ahead of print].

    PubMed  Google Scholar 

  109. Wong KK, Fig LM, Gross MD, Dwamena BA. Parathyroid adenoma localization with 99mTc-sestamibi SPECT/CT: a meta-analysis. Nucl Med Commun. 2015;36:363–75.

    Article  CAS  PubMed  Google Scholar 

  110. Lezaic L, Rep S, Sever MJ, Kocjan T, Hocevar M, Fettich J. 18F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging. 2014;41:2083–9.

    Article  CAS  PubMed  Google Scholar 

  111. Kluijfhout WP, Vorselaars WM, Vriens MR, Borel Rinkes IH, Valk GD, de Keizer B. Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of 18F-fluorocholine PET-CT. Eur J Radiol. 2015;84:1745–51.

    Article  PubMed  Google Scholar 

  112. Estrems P, Guallart F, Abreu P, Sopena P, Dalmau J, Sopena R. The intraoperative mini gamma camera in primary hyperparathyroidism surgery. Acta Otorrinolaringol Esp. 2012;63:450–7.

    Article  PubMed  Google Scholar 

  113. Casáns-Tormo I, Prado-Wohlwend S, Díaz-Expósito R, Cassinello-Fernández N, Ortega-Serrano J. Initial experience in intraoperative radiolocalization of the parathyroid adenoma with freehand SPECT and comparative assessment with portable gamma-camera. Rev Esp Med Nucl Imagen Mol. 2015;34:116–9.

    PubMed  Google Scholar 

  114. Bluemel C, Kirchner P, Kajdi GW, Werner RA, Herrmann K. Localization of parathyroid adenoma with real-time ultrasound: freehand SPECT fusion. Clin Nucl Med. 2016;41:e141–2.

    Article  PubMed  Google Scholar 

  115. De Bree R, Pouw B, Heuveling DA, Castelijns JA. Fusion of freehand SPECT and ultrasound to perform ultrasound-guided fine-needle aspiration cytology of sentinel nodes in head and neck cancer. AJNR Am J Neuroradiol. 2015;36:2153–8.

    Article  PubMed  Google Scholar 

  116. Horenblas S, Kroon BK, Valdes Olmos RA, Nieweg OE. Dynamic sentinel lymph node biopsy in penile carcinoma. In: Mariani G, Giuliano AE, Strauss HW, editors. Radioguided surgery – a comprehensive team approach. New York: Springer; 2008. p. 117–25.

    Google Scholar 

  117. Leijte JA, Hughes B, Graafland NM, Kroon BK, Valdés Olmos RA, Nieweg OE, et al. Two-center evaluation of dynamic sentinel node biopsy for squamous cell carcinoma of the penis. J Clin Oncol. 2009;27:3325–9.

    Article  PubMed  Google Scholar 

  118. Djajadiningrat RS, Graafland NM, van Werkhoven E, Meinhardt W, Bex A, van der Poel HG, et al. Contemporary management of regional nodes in penile cancer-improvement of survival? J Urol. 2014;191:68–73.

    Article  PubMed  Google Scholar 

  119. Leijte JA, Valdés Olmos RA, Nieweg OE, Horenblas S. Anatomical mapping of lymphatic drainage in penile carcinoma with SPECT-CT: implications for the extent of inguinal lymph node dissection. Eur Urol. 2008;54:885–90.

    Article  PubMed  Google Scholar 

  120. Sadeghi R, Tabasi KT, Bazaz SM, Kakhki VR, Massoom AF, Gholami H, et al. Sentinel node mapping in the prostate cancer. Meta-analysis. Nuklearmedizin. 2011;50:107–15.

    Article  CAS  PubMed  Google Scholar 

  121. Van den Bergh L, Joniau S, Haustermans K, Deroose CM, Isebaert S, Oyen R, et al. Reliability of sentinel node procedure for lymph node staging in prostate cancer patients at high risk for lymph node involvement. Acta Oncol. 2015;54:896–902.

    Article  PubMed  CAS  Google Scholar 

  122. Meinhardt W, van der Poel HG, Valdés Olmos RA, Bex A, Brouwer OR, Horenblas S. Laparoscopic sentinel lymph node biopsy for prostate cancer: the relevance of locations outside the extended dissection area. Prostate Cancer. 2012;2012:751753.

    Article  CAS  PubMed  Google Scholar 

  123. Vermeeren L, Meinhardt W, van der Poel HG, Valdés Olmos RA. Lymphatic drainage from the treated versus untreated prostate: feasibility of sentinel node biopsy in recurrent cancer. Eur J Nucl Med Mol Imaging. 2010;37:2012–26.

    Google Scholar 

  124. Krengli M, Ballare A, Cannillo B, Rudoni M, Kocjancic E, Loi G, et al. Potential advantage of studying the lymphatic drainage by sentinel node technique and SPECT/CT image fusion for pelvic irradiation of prostate cancer. Int J Radiat Oncol Biol Phys. 2006;66:1100–4.

    Article  PubMed  Google Scholar 

  125. Rousseau C, Rousseau T, Campion L, Lacoste J, Aillet G, Potiron E, et al. Laparoscopic sentinel lymph node versus hyperextensive pelvic dissection for staging clinically localized prostate carcinoma; a prospective study of 200 patients. J Nucl Med. 2014;55:753–8.

    Article  PubMed  Google Scholar 

  126. De Bonilla-Damiá A, Brouwer OR, Meinhardt W, Valdés Olmos RA. Lymphatic drainage in prostate carcinoma assessed by lymphoscintigraphy and SPECT/CT: its importance for the sentinel node procedure. Rev Esp Med Nucl Imagen Mol. 2012;31:66–70.

    PubMed  Google Scholar 

  127. Vees H, Steiner C, Dipasquale G, Chouiter A, Zilli T, Velazquez M, et al. Target volume definition in high-risk prostate cancer patients using sentinel node SPECT/CT and 18F-choline PET/CT. Radiat Oncol. 2012;7:134.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Maurer T, Gschwend JE, Rauscher I, Souvatzoglou M, Haller B, Weirich G, et al. Diagnostic efficacy of 68Gallium-PSMA-PET compared to conventional imaging in lymph node staging of 130 consecutive patients with intermediate to high-risk prostate cancer. J Urol. 2016;195:1436–43.

    Article  PubMed  Google Scholar 

  129. Schottelius M, Wirtz M, Eiber M, Maurer T, Wester HJ. [111In]PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery. EJNMMI Res. 2015;5:68.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  130. Liss MA, Noguchi J, Lee HJ, Vera DR, Kader AK. Sentinel lymph node biopsy in bladder cancer: systematic review and technology update. Indian J Urol. 2015;31:170–5.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Brouwer OR, Valdés Olmos RA, Vermeeren L, Hoefnagel CA, Nieweg OE, Horenblas S. SPECT/CT and a portable γ-camera for image-guided laparoscopic sentinel node biopsy in testicular cancer. J Nucl Med. 2011;52:551–4.

    Article  PubMed  Google Scholar 

  132. Bex A, Vermeeren L, Meinhardt W, Prevoo W, Horenblas S, Valdés Olmos RA. Intraoperative sentinel node identification and sampling in clinically node-negative renal cell carcinoma: initial experience in 20 patients. World J Urol. 2011;29:793–9.

    Article  CAS  PubMed  Google Scholar 

  133. Brouwer OR, Noe A, Valdes Olmos RA, Bex A. Lymphatic drainage from renal cell carcinoma along the thoracic duct visualized with SPECT/CT. Lymphat Res Biol. 2013;11:233–8.

    Article  CAS  PubMed  Google Scholar 

  134. Covens A, Vella ET, Kennedy EB, Reade CJ, Jimenez W, Le T. Sentinel lymph node biopsy in vulvar cancer: systematic review, meta-analysis and guideline recommendations. Gynecol Oncol. 2015;137:351–61.

    Article  PubMed  Google Scholar 

  135. Te Grootenhuis NC, van der Zee AG, van Doorn HC, van der Velden J, Vergote I, Zanagnolo V, et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I. Gynecol Oncol. 2016;140:8–14.

    Article  Google Scholar 

  136. Paredes P, Vidal-Sicart S. Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the female reproductive system. In: Mariani G, Manca G, Orsini F, Vidal-Sicart S, Valdés Olmos RA, editors. Atlas of lymphoscintigraphy and sentinel node mapping. Milan: Springer; 2013. p. 249–60.

    Chapter  Google Scholar 

  137. Collarino A, Donswijk ML, van Driel WJ, Stokkel MP, Valdés Olmos RA. The use of SPECT/CT for anatomical mapping of lymphatic drainage in vulvar cancer: possible implications for the extent of inguinal lymph node dissection. Eur J Nucl Med Mol Imaging. 2015;42:2064–71.

    Article  PubMed  Google Scholar 

  138. Doorn HC, van Beekhuizen HJ, Gaarenstroom KN, van der Velden J, van der Zee AG, Oonk M, et al. Repeat sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma is feasible. Gynecol Oncol. 2016. [Epub ahead of print].

    Google Scholar 

  139. Verbeek FP, Tummers QR, Rietbergen DD, Peters AA, Schaafsma BE, van de Velde CJ. Sentinel lymph node biopsy in vulvar cancer using combined radioactive and fluorescence guidance. Int J Gynecol Cancer. 2015;25:1086–93

    Article  PubMed  PubMed Central  Google Scholar 

  140. Kadkhodayan S, Hasanzadeh M, Treglia G, Azad A, Yousefi Z, Zarifmahmoudi L, et al. Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: a systematic review and meta-analysis of the pertinent literature. Eur J Surg Oncol. 2015;41:1–20.

    Article  CAS  PubMed  Google Scholar 

  141. Bats AS, Frati A, Mathevet P, Orliaguet I, Querleu D, Zerdoud S, et al. Contribution of lymphoscintigraphy to intraoperative sentinel lymph node detection in early cervical cancer: analysis of the prospective multicenter SENTICOL cohort. Gynecol Oncol. 2015;137:264–9.

    Article  PubMed  Google Scholar 

  142. Hoogendam JP, Veldhuis WB, Hobbelink MG, Verheijen RH, van den Bosch MA, Zweemer RP. 99mTc SPECT/CT versus planar lymphoscintigraphy for preoperative sentinel lymph node detection in cervical aancer: a systematic review and metaanalysis. J Nucl Med. 2015;56:675–80.

    Article  PubMed  Google Scholar 

  143. Giammarile F, Bozkurt MF, Cibula D, Pahisa J, Oyen WJ, Paredes P, et al. The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers. Eur J Nucl Med Mol Imaging. 2014;41:1463–77.

    Article  PubMed  Google Scholar 

  144. Ansari M, Rad MA, Hassanzadeh M, Gholami H, Yousefi Z, Dabbagh VR, Sadeghi R. Sentinel node biopsy in endometrial cancer: systematic review and meta-analysis of the literature. Eur J Gynaecol Oncol. 2013;34:387–401.

    CAS  PubMed  Google Scholar 

  145. Perissinotti A, Paredes P, Vidal-Sicart S, Torné A, Albela S, Navales I, et al. Use of SPECT/CT for improved sentinel lymph node localization in endometrial cancer. Gynecol Oncol. 2013;129:42–8.

    Article  CAS  PubMed  Google Scholar 

  146. Sawicki S, Kobierski J, Lapinska-Szumczyk S, Lass P, Cytawa W, Bianek-Bodzak A, Wydra D. Comparison of SPECT/CT results and intraoperative detection of sentinel lymph nodes in endometrial cancer. Nucl Med Commun. 2013;34:590–6.

    Article  PubMed  Google Scholar 

  147. Mücke J, Klapdor R, Scheider M, Länger F, Gratz KF, Hillemans P, Hertel H. Isthmocervical labeling and SPECT/CT for optimized sentinel node detection in endometrial cancer: technique, experience and results. Gynecol Oncol. 2014;134:287–92.

    Article  PubMed  Google Scholar 

  148. Kleppe M, Brans B, Van Gorp T, Slangen BF, Kruse AJ, Pooters IN, et al. The detection of sentinel nodes in ovarian cancer: a feasibility study. J Nucl Med. 2014;55:1799–804.

    Article  PubMed  Google Scholar 

  149. Nagaraja V, Eslick GD, Cox MR. Sentinel lymph node in oesophageal cancer – a systematic review and meta-analysis. J Gastrointest Oncol. 2014;5:127–41.

    PubMed  PubMed Central  Google Scholar 

  150. Niihara M, Takeuchi H, Nakahara T, Saikawa Y, Takahashi T, Wada N, et al. Sentinel lymph node mapping for 385 gastric cancer patients. J Surg Res. 2016;200:73–81.

    Article  PubMed  Google Scholar 

  151. Balagué C, Pallarés JL. Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the gastrointestinal tract. In: Mariani G, Manca G, Orsini F, Vidal-Sicart S, Valdés Olmos RA, editors. Atlas of lymphoscintigraphy and sentinel node mapping. Milan: Springer; 2013. p. 231–9.

    Chapter  Google Scholar 

  152. Tehranian S, Treglia G, Krag DN, Dabbagh Kakhki VR, Zakavi SR, Sadeghi R, Keshtgar M. Sentinel node mapping in anal canal cancer: systematic review and meta-analysis. J Gastrointestin Liver Dis. 2013;22:321–8.

    PubMed  Google Scholar 

  153. Ambrogi MC, Melfi F, Zirafa C, Lucchi M, De Liperi A, Mariani G, et al. Radio-guided thoracoscopic surgery (RGTS) of small pulmonary nodules. Surg Endosc. 2012;26:914–9.

    Article  PubMed  Google Scholar 

  154. Galetta D, Bellomi M, Grana C, Spaggiari L. Radio-guided localization and resection of small or ill-defined pulmonary lesions. Ann Thorac Surg. 2015;100:1175–80.

    Article  PubMed  Google Scholar 

  155. Tyng CJ, Nogueira VH, Bitencourt AG, Santos LC, Souza TV, Zilio MB, et al. Computed tomographically guided injection of cyanoacrylate in association with preoperative radioguided occult lesion localization of ground-glass opacities. Ann Thorac Surg. 2015;99:1838–40.

    Article  PubMed  Google Scholar 

  156. Taghizadeh Kermani A, Bagheri R, Tehranian S, Shojaee P, Sadeghi R, Krag DN. Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: systematic review and meta-analysis of the literature. Lung Cancer. 2013;80:5–14.

    Article  PubMed  Google Scholar 

  157. Abele JT, Allred K, Clare T, Bédard EL. Lymphoscintigraphy in early-stage non-small cell lung cancer with technetium-99m nanocolloids and hybrid SPECT/CT: a pilot project. Ann Nucl Med. 2014;28:477–83.

    Article  CAS  PubMed  Google Scholar 

  158. García-Talavera P, Ruano R, Rioja ME, Cordero JM, Razola P, Vidal-Sicart S. Radioguided surgery in neuroendocrine tumors. A review of the literature. Rev Esp Med Nucl Imagen Mol. 2014;33:358–65.

    PubMed  Google Scholar 

  159. Heller S, Zanzonico P. Nuclear probes and intraoperative gamma cameras. Semin Nucl Med. 2011;41:166–81.

    Article  PubMed  Google Scholar 

  160. Bellotti C, Castagnola G, Tierno SM, Centanini F, Sparagna A, Vetrone I, et al. Radioguided surgery with combined use of gamma probe and hand-held gamma camera for treatment of papillary thyroid cancer locoregional recurrences: a preliminary study. Eur Rev Med Pharmacol Sci. 2013;17:3362–6.

    CAS  PubMed  Google Scholar 

  161. KleinJan GH, van den Berg NS, de Jong J, Wit EM, Thygessen H, Vegt E, et al. Multimodal hybrid imaging agents for sentinel node mapping as a means to (re)connect nuclear medicine to advances made in robot-assisted surgery. Eur J Nucl Med Mol Imaging. 2016;43:1278–87.

    Google Scholar 

  162. van Oosterom MN, Simon H, Mengus L, Welling MM, van der Poel HG, van den Berg NS et al. Revolutionizing (robot-assisted) laparoscopic gamma tracing using a drop-in gamma probe technology. Am J Nucl Med Mol Imaging 2016;28:1–17.

    Google Scholar 

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Authors and Affiliations

  1. Nuclear Medicine Section and Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 9600, 2300, Leiden, The Netherlands

    Renato A. Valdés Olmos

  2. Nuclear Medicine Department, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, Netherlands

    Renato A. Valdés Olmos

  3. Department of Nuclear Medicine, “Santa Maria della Carità” University Hospital, Novara, Italy

    Federica Orsini

  4. Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria

    Francesco Giammarile

  5. Nuclear Medicine Department, University Hospital Clinic Barcelona, Barcelona, Spain

    Sergi Vidal-Sicart

  6. Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy

    Giuliano Mariani

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  1. Renato A. Valdés Olmos
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  2. Federica Orsini
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  5. Giuliano Mariani
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Correspondence to Renato A. Valdés Olmos .

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  1. Attending Emeritus, Memorial Sloan-Kettering Cancer Center Dept. Radiology, New York, New York, USA

    H. William Strauss

  2. Professor Emeritus, University of Pisa, Pisa, Italy

    Giuliano Mariani

  3. Associate Professor and Director of Nuclear Medicine, University of Pisa, Pisa, Italy

    Duccio Volterrani

  4. Attending Physician, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Steven M. Larson

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Valdés Olmos, R.A., Orsini, F., Giammarile, F., Vidal-Sicart, S., Mariani, G. (2017). Radioguided Surgery: Novel Applications. In: Strauss, H., Mariani, G., Volterrani, D., Larson, S. (eds) Nuclear Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-26067-9_55-2

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  1. Latest

    Radioguided Surgery: New Applications, Approaches, and Strategies
    Published:
    20 April 2022

    DOI: https://doi.org/10.1007/978-3-319-26067-9_55-3

  2. Radioguided Surgery: Novel Applications
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    DOI: https://doi.org/10.1007/978-3-319-26067-9_55-2

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    Radioguided Surgery: Novel Applications
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    DOI: https://doi.org/10.1007/978-3-319-26067-9_55-1

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