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Drug Delivery Systems for Ocular Use

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Pharmacology of Ocular Therapeutics

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Abstract

Various static and dynamic ocular barriers in conjunction with membrane transporters pose a significant challenge for ocular drug therapy. These challenges present unique opportunities for understanding the barriers and overcoming it using novel/innovative drug delivery systems. Recently in response to advent of potent and versatile therapeutic agents, the diversity of conventional ocular formulations has gradually evolved, extending well beyond simple solutions, suspensions and ointments. The field includes a variety of innovative carriers that have shown the capacity to encapsulate wide variety of drugs and macromolecules and maintain extended drug effect in targeted tissues. Vesicular carriers, polymeric and lipid nanoparticles, dendrimers, nanoplexes, nanoemulsions, cubosomes, nanoassemblies, nanomicelles and various hybrid hydrogels as well as drug delivery enhancement devices have been widely explored to overcome various hurdles. This chapter presents an overview about the importance of understanding the blood ocular barriers for developing strategies for appropriate drug delivery systems and applications of innovative carriers for ocular delivery of drugs or macromolecules.

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Authors and Affiliations

  1. School of Materials Science & Engineering, NTU-Northwestern Nanomedicine Institute@NTU, Nanyang Technological University, Singapore, Singapore

    Jayabalan Nirmal PhD

  2. Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India

    Gaurav K. Jain PhD

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  2. Gaurav K. Jain PhD
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Correspondence to Jayabalan Nirmal PhD .

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  1. Ocular Pharmacology and Pharmacy, Dr. RP Centre for Ophthalmic Sciences, New Delhi, India

    Thirumurthy Velpandian

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Nirmal, J., Jain, G.K. (2016). Drug Delivery Systems for Ocular Use. In: Velpandian, T. (eds) Pharmacology of Ocular Therapeutics. Adis, Cham. https://doi.org/10.1007/978-3-319-25498-2_19

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