Skip to main content
SpringerLink
Log in

Development of Glutamatergic and GABAergic Synapses

  • Chapter
  • First Online:
Essentials of Cerebellum and Cerebellar Disorders

  • 76k Accesses

Abstract

Due to its stereotyped cellular architecture, the cerebellum has always constituted a useful model system for studying the basic organization and development of synaptic circuits. This chapter describes the current state of knowledge relating to the development of cerebellar glutamate and GABA synapses and reviews recent studies on the molecular and activity-dependent mechanisms that control the spatial specificity of synaptogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Altman J (1972a) Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J Comp Neurol 145:353–398

    Article  CAS  PubMed  Google Scholar 

  • Altman J (1972b) Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol 145:399–464

    Article  CAS  PubMed  Google Scholar 

  • Altman J (1972c) Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer. J Comp Neurol 145:465–514

    Article  CAS  PubMed  Google Scholar 

  • Ango F, di Cristo G, Higashiyama H et al (2004) Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at Purkinje axon initial segment. Cell 119:257–272

    Article  CAS  PubMed  Google Scholar 

  • Ango F, Wu C, Van der Want JJ et al (2008) Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6:e103

    Article  PubMed  PubMed Central  Google Scholar 

  • Briatore F, Patrizi A, Viltono L et al (2010) Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PLoS ONE 5:e12119

    Article  PubMed  PubMed Central  Google Scholar 

  • Cajal S (1890) Sobre ciertos elementos bipolares del cerebelo joven y algunos detalles mas acerca del crecimiento y evolución de las fibras cerebelosas. Gaceta Sanitaria, Barcelona, pp 1–20

    Google Scholar 

  • Cajal S (1911) Histologie du système nerveux de l’homme et des vertébrés. Maloine, Paris

    Google Scholar 

  • Cathala L, Holderith NB, Nusser Z et al (2005) Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs. Nat Neurosci 8:1310–1318

    Article  CAS  PubMed  Google Scholar 

  • Cesa R, Strata P (2009) Axonal competition in the synaptic wiring of the cerebellar cortex during development and in the mature cerebellum. Neuroscience 162:624–632

    Article  CAS  PubMed  Google Scholar 

  • Dugué GP, Dumoulin A, Triller A et al (2005) Target-dependent use of co-released inhibitory transmitters at central synapses. J Neurosci 25:6490–6498

    Article  PubMed  Google Scholar 

  • Eisenman LM, Schalekamp MP, Voogd J (1991) Development of the cerebellar cortical efferent projection: an in-vitro anterograde tracing study in rat brain slices. Dev Brain Res 60:261–266

    Article  CAS  Google Scholar 

  • Garin N, Escher G (2001) The development of inhibitory synaptic specializations in the mouse deep cerebellar nuclei. Neuroscience 105:431–441

    Article  CAS  PubMed  Google Scholar 

  • Hall AC, Lucas FR, Salinas PC (2000) Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 100:525–535

    Article  CAS  PubMed  Google Scholar 

  • Hámori J, Somogyi J (1983) Differentiation of cerebellar mossy fiber synapses in the rat: a quantitative electron microscope study. J Comp Neurol 220:367–377

    Article  Google Scholar 

  • Hashimoto K, Ichikawa R, Kitamura K et al (2009) Translocation of a “winner” climbing fiber to the Purkinje cell dendrite and subsequent elimination of “losers” from the soma in developing cerebellum. Neuron 63:106–118

    Article  CAS  PubMed  Google Scholar 

  • Larramendi LMH (1969) Analysis of synaptogenesis in the cerebellum of the mouse. In: Llinás R (ed) Neurobiology of cerebellar evolution and development. American Medical Association, Chicago

    Google Scholar 

  • Matsuda K, Miura E, Miyazaki T et al (2010) Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328:363–368

    Article  CAS  PubMed  Google Scholar 

  • McLaughlin BJ, Wood JG, Saito K (1975) The fine structural localization of glutamate decarboxylase in developing axonal processes and presynaptic terminals of rodent cerebellum. Brain Res 85:355–371

    Article  CAS  PubMed  Google Scholar 

  • Nakayama H, Miyazaki T, Kitamura K et al (2012) GABAergic inhibition regulates developmental synapse elimination in the cerebellum. Neuron 74:384–396

    Article  CAS  PubMed  Google Scholar 

  • Palay S, Chan-Palay V (1974) Cerebellar cortex: cytology and organization. Springer, Berlin

    Book  Google Scholar 

  • Pouzat C, Hestrin S (1997) Developmental regulation of basket/stellate cell→Purkinje cell synapses in the cerebellum. J Neurosci 17:9104–9112

    CAS  PubMed  Google Scholar 

  • Sajan SA, Waimey KE, Millen KJ (2010) Novel approaches to studying the genetic basis of cerebellar development. Cerebellum 9:272–283

    Article  PubMed  PubMed Central  Google Scholar 

  • Schilling K, Oberdick J, Rossi F et al (2008) Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex. Histochem Cell Biol 130:601–615

    Article  CAS  PubMed  Google Scholar 

  • Sotelo C (2004) Cellular and genetic regulation of the development of the cerebellar system. Prog Neurobiol 72:295–339

    Article  CAS  PubMed  Google Scholar 

  • Sotelo C (2008) Development of “Pinceaux” formations and dendritic translocation of climbing fibers during the acquisition of the balance between glutamatergic and gamma-aminobutyric acidergic inputs in developing Purkinje cells. J Comp Neurol 506:240–262

    Article  CAS  PubMed  Google Scholar 

  • Uemura T, Lee SJ, Yasumura M et al (2010) Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141:1068–1079

    Article  CAS  PubMed  Google Scholar 

  • Umemori H, Linhoff MW, Ornitz DM et al (2004) FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell 118:257–270

    Article  CAS  PubMed  Google Scholar 

  • Viltono L, Patrizi A, Fritschy JM et al (2008) Synaptogenesis in the cerebellar cortex: differential regulation of gephyrin and GABAA receptors at somatic and dendritic synapses of Purkinje cells. J Comp Neurol 508:579–591

    Article  PubMed  Google Scholar 

  • Wang VY, Zoghbi HY (2001) Genetic regulation of cerebellar development. Nat Rev Neurosci 2:484–491

    Article  CAS  PubMed  Google Scholar 

  • Watt AJ, Cuntz H, Mori M et al (2009) Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity. Nat Neurosci 12:463–473

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yuzaki M (2010) Synapse formation and maintenance by C1q family proteins: a new class of secreted synapse organizers. Eur J Neurosci 32:191–197

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroscience, C.so Massimo d’Azeglio, 52, I-10126, Turin, Italy

    Marco Sassoè-Pognetto

Authors
  1. Marco Sassoè-Pognetto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marco Sassoè-Pognetto .

Editor information

Editors and Affiliations

  1. Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. FNRS, ULB-Erasme, Bruxelles, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Jeremy D. Schmahmann

  6. Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China

    Ying Shen

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Sassoè-Pognetto, M. (2016). Development of Glutamatergic and GABAergic Synapses. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_17

Download citation

Publish with us

Policies and ethics

Search

Navigation