Skip to main content
SpringerLink
Log in

Neuroprotective Effects Associated with Wine and Its Phenolic Constituents

  • Chapter
  • First Online:
Wine Safety, Consumer Preference, and Human Health

Abstract

Epidemiological evidences suggest an inverse correlation between wine consumption and the incidence of neurodegenerative disorders. Although wine is a complex matrix, such benefit is believed to be in large part attributable to the intake of specific polyphenols present in great quantity in wine. Red wines contain between 900 and 1400 mg/L of polyphenols; meanwhile white wines are generally lower in polyphenol content (50–300 mg/L). Nevertheless, Champagne wine has been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. Recent evidences suggest that both red wine and Champagne polyphenols may express their beneficial properties through their interaction with cellular signalling pathways and related machinery that mediate cell function under both normal and pathological conditions. The use of grape-derived phenolic extracts and pure phenolic compounds constitutes a good approach to study the effects of wine consumption in neuroprotection. In this chapter, we aim to provide an overview of the role that wine consumption plays in maintaining cognitive function. We discuss epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions and we consider how their biological mechanisms at the cellular level may underpin their physiological effects. Together, these data indicate that polyphenols present in wine may hold neuroprotective potential in delaying the onset of degenerative disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abraham J, Johnson RW. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res. 2009;12(6):445–53.

    Article  CAS  Google Scholar 

  • Anderson JL, Head SI, Rae C, Morley JW. Brain function in Duchenne muscular dystrophy. Brain. 2002;125(Pt 1):4–13.

    Article  CAS  Google Scholar 

  • Arntzen KA, Schirmer H, Wilsgaard T, Mathiesen EB. Moderate wine consumption is associated with better cognitive test results: a 7 year follow up of 5033 subjects in the Tromsø Study. Acta Neurol Scand. 2010;122 Suppl 190:23–9.

    Article  Google Scholar 

  • Artero A, Artero A, Tarín JJ, Cano A. The impact of moderate wine consumption on health. Maturitas. 2015;80:3–13.

    Article  CAS  Google Scholar 

  • Assunção M, Santos-Marques MJ, De Freitas AV, Carvalho BF, Andrade CJP, Lukoyanova ANV, Paula-Barbosa MM. Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral study. Neuroscience. 2007;146:1581–92.

    Article  Google Scholar 

  • Bastianetto S. Red wine consumption and brain aging. Nutrition. 2002;18(5):432–3.

    Article  CAS  Google Scholar 

  • Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. Int Immunopharmacol. 2005;5(1):185–93.

    Article  CAS  Google Scholar 

  • Bianchini F, Vainio H. Wine and resveratrol: mechanisms of cancer prevention? Eur J Cancer Prevent. 2004;12:417–25.

    Article  Google Scholar 

  • Blanchet J, Longpré F, Bureau G, Morissette M, DiPaolo T, Bronchti G, Martinoli MG. Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5):1243–50.

    Article  CAS  Google Scholar 

  • Bureau G, Longpré F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res. 2008;86(2):403–10.

    Article  CAS  Google Scholar 

  • Chamkha M, Cathala B, Cheynier V, Douillard R. Phenolic composition of champagnes from Chardonnay and Pinot Noir vintages. J Agric Food Chem. 2003;51(10):3179–84.

    Article  CAS  Google Scholar 

  • Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C, Atkinson J. Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat. J Cardiovasc Pharmacol. 2008;51(3):304–10.

    Article  CAS  Google Scholar 

  • Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem. 2005;280:40364–74.

    Article  CAS  Google Scholar 

  • Chen WQ, Zhao XL, Hou Y, Li ST, Hong Y, Wang DL, Cheng YY. Protective effects of green tea polyphenols on cognitive impairments induced by psychological stress in rats. Behav Brain Res. 2009;202(1):71–6.

    Article  CAS  Google Scholar 

  • Cheng D, Xi Y, Cao J, Cao D, Ma Y, Jiang W. Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat. Neurotoxicology. 2014;45:111–20.

    Article  CAS  Google Scholar 

  • Choi DY, Lee YJ, Hong JT, Lee HJ. Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer’s disease. Brain Res Bull. 2012;87(2–3):144–53.

    Article  CAS  Google Scholar 

  • Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF. Intake of flavonoids and risk of dementia. Eur J Epidemiol. 2000;16(4):357–63.

    Article  CAS  Google Scholar 

  • Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. 1997;8(10):645–9.

    Article  CAS  Google Scholar 

  • Corder R. Red wine, chocolate and vascular health: developing the evidence base. Heart. 2008;94(7):821–3.

    Article  Google Scholar 

  • Corona G, Vauzour D, Hercelin J, Williams CM, Spencer JP. Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation. Antioxid Redox Signal. 2013;19(14):1676–89.

    Article  CAS  Google Scholar 

  • De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV. Alzheimer’s disease. Subcell Biochem. 2012;65:329–52.

    Article  CAS  Google Scholar 

  • Field DT, Williams CM, Butler LT. Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav. 2011;103(3–4):255–60.

    Article  CAS  Google Scholar 

  • Giacoppo S, Galuppo M, Lombardo GE, Ulaszewska MM, Mattivi F, Bramanti P, Mazzon E, Navarra M. Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis. Fitoterapia. 2015;103:171–86.

    Article  CAS  Google Scholar 

  • Glisky EL. Changes in cognitive function in human aging. In: Riddle DR, editor. Brain aging: models, methods, and mechanisms. Frontiers in neuroscience. Boca Raton, FL: CRC Press; 2007. p. 3–20. xix, 384 pp.

    Chapter  Google Scholar 

  • Goda Y. Cadherins communicate structural plasticity of presynaptic and postsynaptic terminals. Neuron. 2002;35(1):1–3.

    Article  CAS  Google Scholar 

  • Harada N, Zhao J, Kurihara H, Nakagata N, Okajima K. Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus. J Nutr Biochem. 2011;22(12):1150–9.

    Article  CAS  Google Scholar 

  • Hayakawa N, Kato H, Araki T. Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector. Mech Ageing Dev. 2007;128(4):311–6.

    Google Scholar 

  • Ho L, Yemula S, Wanga J, Pasinettia GM. Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies. J Alzheimers Dis. 2009a;16(2):433–9.

    CAS  Google Scholar 

  • Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer’s disease-type neuropathology and cognitive deterioration. J Alzheimers Dis. 2009b;16:59–72.

    CAS  Google Scholar 

  • Huang Q, Wu LJ, Tashiro S, Gao HY, Onodera S, Ikejima T.(+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest.J Pharmacol Sci. 2005 May;98(1):16-24. Epub 2005 May 7.

    Google Scholar 

  • Hurley LL, Akinfiresoye L, Kalejaiye O, Tizabi Y. Antidepressant effects of resveratrol in an animal model of depression. Behav Brain Res. 2014;268:1–7.

    Article  CAS  Google Scholar 

  • Hvidtfeldt UA, Frederiksen ME, Thygesen LC, Kamper-Jorgensen M, Becker U, Gronbaek M. Incidence of cardiovascular and cerebrovascular disease in Danish men and women with a prolonged heavy alcohol intake. Alcohol Clin Exp Res. 2008;32(11):1920–4.

    Google Scholar 

  • Jackson DI, Lombard PB. Environmental and management-practices affecting grape composition and wine quality - a review. Am J Enol Viticult. 1993;44(4):409–30.

    CAS  Google Scholar 

  • Jang JH, Surh YJ. Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med. 2003;34:1100–10.

    Article  CAS  Google Scholar 

  • Janle EM, Lila MA, Grannan M, Wood L, Higgins A, Yousef GG, Rogers RB, Kim H, Jackson GS, Ho L, Weaver CM. Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration. J Med Food. 2010;13(4):926–33.

    Article  CAS  Google Scholar 

  • Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int. 2009;54:111–8.

    Article  CAS  Google Scholar 

  • Kim CY, Lee C, Park GH, Jang JH. Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity. Arch Pharm Res. 2009;32:869–81.

    Article  CAS  Google Scholar 

  • Kim J, Lee HJ, Lee KW. Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. J Neurochem. 2010;112:1415–30.

    Article  CAS  Google Scholar 

  • Klatsky AL, Friedman GD, Armstrong MA, Kipp H. Wine, liquor, beer, and mortality. Am J Epidemiol. 2003;15:585–95.

    Article  Google Scholar 

  • Koda T, Kuroda Y, Imai H. Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury. Cell Mol Neurobiol. 2009;29:523–31.

    Article  CAS  Google Scholar 

  • Lee YK, Yuk DY, Lee JW, Lee SY, Ha TY, Oh KW, Yun YP, Hong JT. (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency. Brain Res. 2009;1250:164–74.

    Article  CAS  Google Scholar 

  • Lemeshow S, Letenneur L, Dartigues JF, Lafont S, Orgogozo JM, Commenges D. Illustration of analysis taking into account complex survey considerations: the association between wine consumption and dementia in the PAQUID study. Personnes Ages Quid. Am J Epidemiol. 1998;148(3):298–306.

    Article  CAS  Google Scholar 

  • Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006;440:352–7.

    Article  Google Scholar 

  • Letenneur L. Risk of dementia and alcohol and wine consumption: a review of recent results. Biol Res. 2004;37(2):189–93.

    Article  Google Scholar 

  • Li MH, Jang JH, Sun B, Surh YJ. Protective effects of oligomers of grape seed polyphenols against β-amyloid-induced oxidative cell death. Ann N Y Acad Sci. 2004a;1030:317–29.

    Article  CAS  Google Scholar 

  • Li YJ, Hauser MA, Scott WK, Martin ER, Booze MW, Qin XJ, Walter JW, Nance MA, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Small GW, Mastaglia F, Haines JL, Pericak-Vance JM. Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology. 2004b;62(11):2005–9.

    Article  CAS  Google Scholar 

  • Liu P, Kemper LJ, Wang J, Zahs KR, Ashe KH, Pasinetti GM. Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of tg2576 mice. J Alzheimers Dis. 2011;26:657–66.

    CAS  Google Scholar 

  • Manach C, Scalbert A, Morand C, Remesy C, Jimenez I. Polyphenols: food sources and bioavailablity. Am J Clin Nutr. 2004;79:727–47.

    CAS  Google Scholar 

  • Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides.J Biol Chem. 2005 Nov 11;280(45):37377-82. Epub 2005 Sep 14.

    Google Scholar 

  • Meiergerd SM, Schenk JO. Striatal transporter for dopamine: catechol structure-activity studies and susceptibility to chemical modification. J Neurochem. 1994;62(3):998–1008.

    Article  CAS  Google Scholar 

  • Muntoni F, Mateddu A, Serra G. Passive avoidance behaviour deficit in the mdx mouse. Neuromuscul Disord. 1991;1(2):121–3.

    Article  CAS  Google Scholar 

  • Napoli R, Cozzolino D, Guardasole V, Angelini V, Zarra E, Matarazzo M. Red wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients. Metabolism. 2005;54:306–13.

    Article  CAS  Google Scholar 

  • Nurk E, Refsum H, Drevon CA, Tell GS, Nygaard HA, Engedal K, Smith AD. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J Nutr. 2009;139(1):120–7.

    Article  CAS  Google Scholar 

  • Nurk E, Refsum H, Drevon CA, Tell GS, Nygaard HA, Engedal K, Smith AD. Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. Br J Nutr. 2010;104:1190–201.

    Article  CAS  Google Scholar 

  • Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003;348(14):1356–64.

    Article  CAS  Google Scholar 

  • Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB. Effects of grape seed-derived polyphenols on amyloid beta-protein selfassembly and cytotoxicity. J Biol Chem. 2008;283:32176–87.

    Article  CAS  Google Scholar 

  • Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, Breteler M. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol. 1997;153:185–92.

    CAS  Google Scholar 

  • Panza F, Capurso C, D’Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V. Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. J Alzheimers Dis. 2009;17(1):7–31.

    Google Scholar 

  • Papandreou MA, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res. 2009;198(2):352–8.

    Article  CAS  Google Scholar 

  • Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L. Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment. Biochim Biophys Acta. 2015;1852(6):1202–8.

    Article  CAS  Google Scholar 

  • Polidori MC, Pratico D, Mangialasche F, Mariani E, Aust O, Anlasik T, Mang N, Pientka L, Stahl W, Sies H, Mecocci P, Nelles G. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis. 2009;17:921–7.

    CAS  Google Scholar 

  • Priel A, Tuszynski JA, Woolf NJ. Neural cytoskeleton capabilities for learning and memory. J Biol Phys. 2009;36(1):3–21.

    Article  Google Scholar 

  • Rainey-Smith S, Schroetke LW, Bahia P, Fahmi A, Skilton R, Spencer JP, Rice-Evans C, Rattray M, Williams RJ. Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neurosci Lett. 2008;438(1):29–33.

    Article  CAS  Google Scholar 

  • Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol. 2006;545:51–64.

    Article  CAS  Google Scholar 

  • Rehm JT, Bondy SJ, Sempos CT, Vuong CV. Alcohol consumption and coronary heart disease morbidity and mortality. Am J Epidemiol. 1997;146:495–501.

    Article  CAS  Google Scholar 

  • Rendeiro C, Vauzour D, Kean RJ, Butler LT, Rattray M, Spencer JP, Williams CM. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology (Berl). 2012;223:319.

    Article  CAS  Google Scholar 

  • Rice-Evans CA, Miller NJ. Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans. 1996;24(3):790–5.

    Article  CAS  Google Scholar 

  • Rocha-González HI, Ambriz-Tututi M, Granados-Soto V. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. CNS Neurosci Ther. 2008;14(3):234–47.

    Article  Google Scholar 

  • Sabogal-Guáqueta AM, Muñoz-Manco JI, Ramírez-Pineda JR, Lamprea-Rodriguez M, Osorio E, Cardona-Gomez GP. The flavonoid quercetin ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice. Neuropharmacology. 2015;93:134–45.

    Article  Google Scholar 

  • Scalbert A, Manach C, Morand C, Remesy C, Jimenez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45:287–306.

    Article  CAS  Google Scholar 

  • Schroeter H, Boyd C, Spencer JP, Williams RJ, Cadenas E, Rice-Evans C. MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol Aging. 2002;23(5):861–80.

    Article  CAS  Google Scholar 

  • Shukitt-Hale B, Cheng V, Joseph JA. Effects of blackberries on motor and cognitive function in aged rats. Nutr Neurosci. 2009;12(3):135–40.

    Article  CAS  Google Scholar 

  • Spencer JP. The impact of flavonoids on memory: physiological and molecular considerations. Chem Soc Rev. 2009;38:1152–61.

    Article  CAS  Google Scholar 

  • Spencer JPE, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2012;33:83–97.

    Article  CAS  Google Scholar 

  • Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F. Effects of moderate alcohol consumption on cognitive function in women. N Engl J Med. 2005;352:245–53.

    Article  CAS  Google Scholar 

  • Tang BL. Resveratrol is neuroprotective because it is not a direct activator of SIRT1-A hypothesis. Brain Res Bull. 2010;81:359–61.

    Article  CAS  Google Scholar 

  • Truelsen T, Thudium D, Grønbaek M. Copenhagen City Heart Study. Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology. 2002;59(9):1313–9.

    Article  Google Scholar 

  • Tsai SJ, Chao CY, Yin MC. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. Eur J Pharmacol. 2011;670(2–3):441–7.

    Article  CAS  Google Scholar 

  • Vafeiadou K, Vauzour D, Spencer JP. Neuroinflammation and its modulation by flavonoids. Endocr Metab Immune Disord Drug Targets. 2007;7(3):211–24.

    Article  CAS  Google Scholar 

  • Vaillend C, Ungerer A. Behavioral characterization of mdx3cv mice deficient in C-terminal dystrophins. Neuromuscul Disord. 1999;9(5):296–304.

    Article  CAS  Google Scholar 

  • Vaillend C, Billard JM, Laroche S. Impaired long-term spatial and recognition memory and enhanced CA1 hippocampal LTP in the dystrophin-deficient Dmd(mdx) mouse. Neurobiol Dis. 2004;17(1):10–20.

    Article  CAS  Google Scholar 

  • Valls-Pedret C, Lamuela-Raventos RM, Medina-Remon A, Quintana M, Corella D, Pinto X, Martinez-Gonzalez MA, Estruch R, Ros E. Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimers Dis. 2012;29(4):773–82.

    CAS  Google Scholar 

  • Vauzour D, Vafeiadou K, Corona G, Pollard SE, Tzounis X, Spencer JP. Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J Agric Food Chem. 2007;55(8):2854–60.

    Article  CAS  Google Scholar 

  • Vauzour D, Ravaioli G, Vafeiadou K, Rodriguez-Mateos A, Angeloni C, Spencer JP. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson’s disease and protection by polyphenols. Arch Biochem Biophys. 2008;476(2):145–51.

    Article  CAS  Google Scholar 

  • Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, Spencer JPE. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients. 2010a;2:1106–31.

    Article  CAS  Google Scholar 

  • Vauzour D, Corona G, Spencer JPE. Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Arch Biochem Biophys. 2010b;501:106–11.

    Article  CAS  Google Scholar 

  • Vlkolinsky R, Cairns N, Fountoulakis M, Lubec G. Decreased brain levels of 2′,3′-cyclic nucleotide-3′-phosphodiesterase in Down syndrome and Alzheimer’s disease. Neurobiol Aging. 2001;22(4):547–53.

    Article  CAS  Google Scholar 

  • Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. Moderate consumption of Cabernet Sauvignon attenuates A-beta neuropathology in a mouse model of Alzheimer’s disease. FASEB J. 2006;20:2313–20.

    Article  CAS  Google Scholar 

  • Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM. Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease. J Neurosci. 2008;28:6388–92.

    Article  CAS  Google Scholar 

  • Wang Q, Sun AY, Simonyi A, Miller DK, Smith RE, Luchtefeld RG, Korthuis RJ, Sun GY. Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration. J Nutr Biochem. 2009a;20(5):369–77.

    Article  CAS  Google Scholar 

  • Wang YJ, Thomas P, Zhong JH, Bi FF, Kosaraju S, Pollard A, Fenech M, Zhou XF. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer’s disease mouse. Neurotox Res. 2009b;15:3–14.

    Article  Google Scholar 

  • Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2010;22:653–61.

    Google Scholar 

  • Wei X, Zhao L, Ma Z, Holtzman DM, Yan C, Dodel RC, Hampel H, Oertel W, Farlow MR, Du Y. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 2004;127(Pt 12):2629–35.

    Article  Google Scholar 

  • Wei X, Ma Z, Fontanilla CV, Zhao L, Xu ZC, Taggliabraci V, Johnstone BH, Dodel RC, Farlow MR, Du Y. Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity. Neuroscience. 2008;155(4):1098–105.

    Article  CAS  Google Scholar 

  • Weyerer S, Schaufele M, Wiese B, Maier W, Tebarth F, van den Bussche H, Pentzek M, Bickel H, Luppa M, Riedel-Heller SG. Current alcohol consumption and its relationship to incident dementia: results from a 3-year follow-up study among primary care attenders aged 75 years and older. Age Ageing. 2011;40(4):456–63.

    Article  Google Scholar 

  • Xu Y, Zhang JJ, Xiong L, Zhang L, Sun D, Liu H. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. J Nutr Biochem. 2010;21(8):741–8.

    Article  CAS  Google Scholar 

  • Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C. Interaction between flavonoids and the blood–brain barrier: in vitro studies. J Neurochem. 2003;85:180–92.

    Article  CAS  Google Scholar 

  • Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic Biol Med. 2004;36:592–604.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Biotechnology and Microbiology, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, C/Nicolás Cabrera, 9, 28049, Madrid, Spain

    Adelaida Esteban-Fernández

  2. Health Science Research Centre, Life Sciences Department, University of Roehampton, London, SW15 4JD, UK

    Giulia Corona

  3. Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK

    David Vauzour

  4. Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights Campus, Reading, RG6 6AP, UK

    Jeremy P. E. Spencer

Authors
  1. Adelaida Esteban-Fernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giulia Corona
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Vauzour
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jeremy P. E. Spencer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeremy P. E. Spencer .

Editor information

Editors and Affiliations

  1. CSIC-UAM Madrid, Spain, CIAL-Institute of Food Science Research, Madrid, Spain

    M. Victoria Moreno-Arribas

  2. CSIC-UAM Madrid, Spain, CIAL-Institute of Food Science Research, Madrid, Spain

    Begoña Bartolomé Suáldea

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Esteban-Fernández, A., Corona, G., Vauzour, D., Spencer, J.P.E. (2016). Neuroprotective Effects Associated with Wine and Its Phenolic Constituents. In: Moreno-Arribas, M., Bartolomé Suáldea, B. (eds) Wine Safety, Consumer Preference, and Human Health. Springer, Cham. https://doi.org/10.1007/978-3-319-24514-0_14

Download citation

Publish with us

Policies and ethics

Search

Navigation