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Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma

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Epstein Barr Virus Volume 1

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 390))

Abstract

The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.

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Abbreviations

BCR:

B-cell receptor

B2m:

Beta-2 microglobulin

CTL:

Cytotoxic T lymphocyte

DDR1:

Discoidin domain receptor 1

DLBCL:

Diffuse large B-cell lymphoma

EBERS:

EBV-encoded RNAs

EBNA:

EBV nuclear antigen

EBF1:

Early B-cell factor 1

EBV:

Epstein-Barr virus

HAART:

Highly active anti-retroviral therapy

HRS:

Hodgkin and Reed-Sternberg

HL:

Hodgkin lymphoma

HLA:

Human leucocyte antigen

IM:

Infectious mononucleosis

ITAM:

Immunoreceptor tyrosine activation motif

JAK:

Janus kinase

L&H:

Lymphocytic and histiocytic

LMP:

Latent membrane protein

NF-κB:

Nuclear factor kappa B

NLP:

Nodular lymphocyte predominant

PD-L1:

Programmed cell death-ligand 1

PI3K:

Phosphatidylinositol-3-kinase

REAL:

Revised European American Lymphoma

RTK:

Receptor tyrosine kinase

STAT:

Signal transducer and activator of transcription

TGFβ:

Transforming growth factor β

TNF:

Tumour necrosis factor

WHO:

World Health Organization

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Acknowledgments

We are grateful to Leukaemia Lymphoma Research and to Cancer Research UK for support.

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  1. School of Cancer Sciences and Centre for Human Virology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK

    Paul Murray & Andrew Bell

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  1. Paul Murray
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  2. Andrew Bell
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Correspondence to Paul Murray .

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  1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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Murray, P., Bell, A. (2015). Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma. In: Münz, C. (eds) Epstein Barr Virus Volume 1. Current Topics in Microbiology and Immunology, vol 390. Springer, Cham. https://doi.org/10.1007/978-3-319-22822-8_12

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