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Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

  • Chapter
Book cover The Alkali Metal Ions: Their Role for Life

Part of the book series: Metal Ions in Life Sciences ((MILS,volume 16))

Abstract

As a physiological phenomenon, acid secretion from the stomach was known already at least in the 17th century. But its mechanism was elucidated in more recent times only. At the end of the 20th century, gastric H+/K+-ATPase in the parietal cells was found to be responsible for a final step of H+ secretion in these cells. In this century, several Cl−-transporting proteins for gastric acid (hydrochloric acid; HCl) secretion have been found. As inhibitors of gastric acid secretion, histamine H2 receptor antagonists (H2 blockers) were developed in the 1970’s. This discovery brought a great benefit; that is, peptic ulcers became treatable by administration of a drug. In 1980’s, proton pump inhibitors (PPIs) were developed. The target of PPIs is gastric H+/K+-ATPase and the PPIs exert generally more potent effects compared with H2 blockers. Most recently, several K+-competitive inhibitors of the ATPase are being developed. Here, we introduce gastric H+/K+-ATPase and its related proteins for gastric acid secretion, and several gastric diseases and their treatment by medicines.

Please cite as: Met. Ions Life Sci. 16 (2016) 459–483

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Acknowledgment

Our scientific studies described in this chapter were partly supported by Grants-in-aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science and Grants-in-aid the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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  1. Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama City, Toyama, 930-0194, Japan

    Hideki Sakai & Takuto Fujii

  2. Takeguchi Digestive Research, Toyama, 930-0125, Japan

    Noriaki Takeguchi

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Correspondence to Hideki Sakai .

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  1. Department of Chemistry Inorganic Chemistry, University of Basel, Basel, Basel Stadt, Switzerland

    Astrid Sigel

  2. Department of Chemistry Inorganic Chemistry, University of Basel, Basel, Switzerland

    Helmut Sigel

  3. Department of Chemistry, University of Zürich, Zürich, Switzerland

    Roland K. O. Sigel

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Sakai, H., Fujii, T., Takeguchi, N. (2016). Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases. In: Sigel, A., Sigel, H., Sigel, R. (eds) The Alkali Metal Ions: Their Role for Life. Metal Ions in Life Sciences, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-21756-7_13

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