Skip to main content

Infections of the External Ear

  • Chapter

Abstract

Acute otitis externa, “swimmer’s ear”, is a common infection of childhood and a frequent cause of urgent clinic visits during the summer months. Most children present with ear pain and otorrhea, have an uncomplicated illness, and are effectively managed by their primary care physician. For patients with severe or complicated disease, the experience and knowledge of the otorhinolaryngologist and/or the infectious disease physician is helpful. Herein, we describe the epidemiology, pathogenesis, diagnosis, and management of acute otitis externa, emphasizing the guidelines of the American Academy of Otolaryngology—Head and Neck Surgery Foundation and highlighting aspects of care important for the care of children. Furthermore, we discuss several less common infections involving the external ear—necrotizing otitis externa, fungal otitis externa, herpes zoster oticus, and Ramsay-Hunt syndrome. These infections often prove challenging for the specialist and generalist alike. Lastly, we briefly review inflammatory conditions that should be included in the differential of infections of the external ear.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

AAO-HNSF:

American Academy of Otolaryngology—Head and Neck Surgery Foundation

AOE:

Acute otitis externa

EAC:

External auditory canal

NOE:

Necrotizing otitis externa

RHS:

Ramsey-Hunt syndrome

RP:

Relapsing polychondritis

VZV:

Varicella-zoster virus

References

  1. Linstrom C, Lucente F. Diseases of the external ear. In: Johnson JT, Rosen CA, editors. Bailey’s head and neck surgery otolaryngology. Philadelphia: Lippincott Williams & Wilkins; 2014. p. 2333–57.

    Google Scholar 

  2. Moore KL, Dalley AF. Clinically oriented anatomy. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 1999. p. 962.

    Google Scholar 

  3. Friedman E, Carrillo-Marquez M. Otitis externa. In: Cherry JD, Demmler-Harrison GJ, editors. Feigin and Cherry’s textbook of pediatric infectious diseases. 7th ed. Philadelphia: Elsevier; 2014. p. 203–9.

    Google Scholar 

  4. Centers for Disease Control and Prevention (CDC). Estimated burden of acute otitis externa—United States, 2003–2007. MMWR Morb Mortal Wkly Rep. 2011;60(19):605–9.

    Google Scholar 

  5. Chai TJ, Chai TC. Bactericidal activity of cerumen. Antimicrob Agents Chemother. 1980;18(4):638–41.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Wright DN, Alexander JM. Effect of water on the bacterial flora of swimmers’ ears. Arch Otolaryngol. 1974;99(1):15–8.

    Article  CAS  PubMed  Google Scholar 

  7. Reid TM, Porter IA. An outbreak of otitis externa in competitive swimmers due to Pseudomonas aeruginosa. J Hyg (Lond). 1981;86(3):357–62.

    Article  CAS  Google Scholar 

  8. Van Asperen IA, de Rover CM, Schijven JF, Oetomo SB, Schellekens JF, van Leeuwen NJ, et al. Risk of otitis externa after swimming in recreational fresh water lakes containing Pseudomonas aeruginosa. BMJ. 1995;311(7017):1407–10.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Wade TJ, Sams EA, Beach MJ, Collier SA, Dufour AP. The incidence and health burden of earaches attributable to recreational swimming in natural waters: a prospective cohort study. Environ Health. 2013;12:67.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Stroman DW, Roland PS, Dohar J, Burt W. Microbiology of normal external auditory canal. Laryngoscope. 2001;111(11 Pt 1):2054–9.

    Article  CAS  PubMed  Google Scholar 

  11. Dibb WL. Microbial aetiology of otitis externa. J Infect. 1991;22(3):233–9.

    Article  CAS  PubMed  Google Scholar 

  12. Clark WB, Brook I, Bianki D, Thompson DH. Microbiology of otitis externa. Otolaryngol Head Neck Surg. 1997;116(1):23–5.

    Article  CAS  PubMed  Google Scholar 

  13. Jones RN, Milazzo J, Seidlin M. Ofloxacin otic solution for treatment of otitis externa in children and adults. Arch Otolaryngol Head Neck Surg. 1997;123(11):1193–200.

    Article  CAS  PubMed  Google Scholar 

  14. Drehobl M, Guerrero JL, Lacarte PR, Goldstein G, Mata FS, Luber S. Comparison of efficacy and safety of ciprofloxacin otic solution 0.2% versus polymyxin B-neomycin-hydrocortisone in the treatment of acute diffuse otitis externa. Curr Med Res Opin. 2008;24(12):3531–42.

    Article  CAS  PubMed  Google Scholar 

  15. Roland PS, Stroman DW. Microbiology of acute otitis externa. Laryngoscope. 2002;112(7 Pt 1):1166–77.

    Article  PubMed  Google Scholar 

  16. Brook I, Frazier EH, Thompson DH. Aerobic and anaerobic microbiology of external otitis. Clin Infect Dis. 1992;15(6):955–8.

    Article  CAS  PubMed  Google Scholar 

  17. Rosenfeld RM, Schwartz SR, Cannon CR, Roland PS, Simon GR, Kumar KA, et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150(1 Suppl):S1–24.

    Article  PubMed  Google Scholar 

  18. Ohyama M, Furuta S, Ueno K, Katsuda K, Nobori T, Kiyota R, et al. Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations. Arch Otolaryngol Head Neck Surg. 1999;125(3):337–40.

    Article  CAS  PubMed  Google Scholar 

  19. Weber PC, Roland PS, Hannley M, Friedman R, Manolidis S, Matz G, et al. The development of antibiotic resistant organisms with the use of ototopical medications. Otolaryngol Head Neck Surg. 2004;130(3 Suppl):S89–94.

    Article  PubMed  Google Scholar 

  20. Rosenfeld RM, Singer M, Wasserman JM, Stinnett SS. Systematic review of topical antimicrobial therapy for acute otitis externa. Otolaryngol Head Neck Surg. 2006;134(4 Suppl):S24–48.

    Article  PubMed  Google Scholar 

  21. Van Balen FA, Smit WM, Zuithoff NP, Verheij TJ. Clinical efficacy of three common treatments in acute otitis externa in primary care: randomized controlled trial. BMJ. 2003;327(7425):1201–5.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Roland PS, Belcher BP, Bettis R, Makabale RL, Conroy PJ, Wall GM, et al. A single topical agent is clinically equivalent to the combination of topical and oral antibiotic treatment for otitis externa. Am J Otolaryngol. 2008;29(4):255–61.

    Article  CAS  PubMed  Google Scholar 

  23. Sabater F, Maristany M, Mensa J, Vaillar E, Traserra J. Prospective double-blind randomized study of the efficacy and tolerance of topical ciprofloxacin vs topical gentamicin in the treatment of simple chronic otitis media and diffuse external otitis. Acta Otorrinolaringol Esp. 1996;47(3):217–20.

    CAS  PubMed  Google Scholar 

  24. Rahman A, Rizwan S, Waycaster C, Wall GM. Pooled analysis of two clinical trials comparing the clinical outcomes of topical ciprofloxacin/dexamethasone otic suspension and polymyxin B/neomycin/hydrocortisone otic suspension for the treatment of acute otitis externa in adults and children. Clin Ther. 2007;29(9):1950–6.

    Article  CAS  PubMed  Google Scholar 

  25. Dohar JE. Evolution of management approaches for otitis externa. Pediatr Infect Dis J. 2003;22(4):299–305.

    PubMed  Google Scholar 

  26. Bhattacharyya N, Kepnes LJ. Initial impact of the acute otitis externa clinical practice guidelines on clinical care. Otolaryngol Head Neck Surg. 2011;145(3):414–7.

    Article  PubMed  Google Scholar 

  27. McCoy SI, Zell ER, Besser RE. Antimicrobial prescribing for otitis externa in children. Pediatr Infect Dis J. 2004;23(2):181–3.

    Article  PubMed  Google Scholar 

  28. Roland PS, Rybak L, Hannley M, Matz G, Stewart MG, Manolidis S, et al. Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngol Head Neck Surg. 2004;130(3 Suppl):S57–78.

    Article  PubMed  Google Scholar 

  29. Berenholz LP, Burkey JM, Farmer TL, Lippy WH. Topical otic antibiotics: clinical cochlear ototoxicity and cost consideration. Otolaryngol Head Neck Surg. 2006;135(2):291–4.

    Article  PubMed  Google Scholar 

  30. Matz G, Rybak L, Roland PS, Hannley M, Friedman R, Manolidis S, et al. Ototoxicity of ototopical antibiotic drops in humans. Otolaryngol Head Neck Surg. 2004;130(3 Suppl):S79–82.

    Article  PubMed  Google Scholar 

  31. Torum B, Block SL, Avila H, Montiel F, Oliva A, Quintanilla W. Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial. Clin Ther. 2004;26(7):1046–54.

    Article  PubMed  Google Scholar 

  32. Van Ginkel CJ, Bruintjes TD, Huizing EH. Allergy due to topical medications in chronic otitis externa and chronic otitis media. Clin Otolaryngol Allied Sci. 1995;20(4):326–8.

    Article  PubMed  Google Scholar 

  33. Rubin J, Yu VL, Stool SE. Malignant external otitis in children. J Pediatr. 1998;113(6):965–70.

    Article  Google Scholar 

  34. Rubin Grandis J, Branstetter BF, Yu VL. The changing face of malignant (necrotizing) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis. 2004;4(1):34–9.

    Article  PubMed  Google Scholar 

  35. Lee JE, Song JJ, Oh SH, Chang SO, Kim CH, Lee JH. Prognostic value of extension patterns on follow-up magnetic resonance imaging in patients with necrotizing otitis externa. Arch Otolaryngol Head Neck Surg. 2011;137(7):688–93.

    Article  PubMed  Google Scholar 

  36. Bradley JS, Jackson MA. The use of systemic and topical fluoroquinolones. Pediatrics. 2011;128(4):e1034–45.

    Article  PubMed  Google Scholar 

  37. Vennewald I, Klemm E. Otomycosis: diagnosis and treatment. Clin Dermatol. 2010;28:202–11.

    Article  PubMed  Google Scholar 

  38. Ho T, Vrabec J, et al. Otomycosis: clinical features and treatment implications. Otolaryngo Head Neck Surg. 2006;135:787–91.

    Article  Google Scholar 

  39. Munguia R, Daniek S. Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol. 2008;72:453–9.

    Article  PubMed  Google Scholar 

  40. Hirsch B. Infections of the external ear. Am J Otolaryngol. 1992;13(3):145–55.

    Article  CAS  PubMed  Google Scholar 

  41. Kansu L, Yilmaz I. Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. Int J Pediatr Otorhinolaryngol. 2012;76(6):772–6.

    Article  PubMed  Google Scholar 

  42. Hato N, Kisaki H, Honda N, Gyo K, Murakami S, Yanagihara N. Ramsay Hunt syndrome in children. Ann Neurol. 2000;48(2):254–6.

    Article  CAS  PubMed  Google Scholar 

  43. Demos M, McLeod MP. Recurrent furunculosis: a review of the literature. Br J Dermatol. 2012;167:725–32.

    Article  CAS  PubMed  Google Scholar 

  44. Cody DTR, Sones DA. Relapsing polychondritis: audiovestibular manifestations. Laryngoscope. 1971;81:1208–22.

    Article  CAS  PubMed  Google Scholar 

  45. Edgar B, Blevins N, et al. Otologic manifestations of relapsing polychondritis. Review of literature and report of nine cases. Auris Nasus Larynx. 2006;33:135–41.

    Article  Google Scholar 

  46. Gergely P, Poor G. Relapsing polychondritis. Best Pract Res Clin Rheumatol. 2004;18(5):723–38.

    Article  PubMed  Google Scholar 

  47. Cockerill D. Allergies to ear molds. Br J Audiol. 1987;21:143–5.

    Article  CAS  PubMed  Google Scholar 

  48. Fraki JE, Kalimo K, et al. Contact allergy to various components of topical preparations for treatment of external otitis. Acta Otolaryngol. 1985;100:414–8.

    Article  CAS  PubMed  Google Scholar 

  49. Carruthers JA, Cronin E. Incidence of neomycin and framycetin sensitivity. Contact Dermatitis. 1976;2:269–70.

    Article  CAS  PubMed  Google Scholar 

  50. Parila V, Hirvonen ML, et al. The pattern of cross sensitivity to neomycin secondary sensitization to gentamycin. Dermatologica. 1986;136:321–4.

    Article  Google Scholar 

  51. Smith IM, Keay DG, et al. Chronic hypersensitivity in patients with chronic otitis externa. Clin Otolaryngol. 1990;15:155–8.

    Article  CAS  PubMed  Google Scholar 

  52. Beltrani VS, Beltrani VP. Contact dermatitis. Ann Allergy Asthma Immunol. 1997;78:160–73.

    Article  CAS  PubMed  Google Scholar 

  53. Sood S, Strachan DR, et al. Allergic otitis externa. Clin Otolaryngol. 2002;27:233–6.

    Article  CAS  PubMed  Google Scholar 

  54. Guss J, Ruckenstein MJ. Infections of the external ear. In: Flint PW, Haughey BH, editors. Cummings otolaryngology head and neck surgery. Philadelphia: Mosby; 2010. p. 1944–59.

    Chapter  Google Scholar 

  55. Onerci TM. Diagnosis in otorhinolaryngology. Berlin: Springer; 2009.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan D. Crews M.D., M.S. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Musso, M.F., Crews, J.D. (2016). Infections of the External Ear. In: Valdez, T., Vallejo, J. (eds) Infectious Diseases in Pediatric Otolaryngology. Springer, Cham. https://doi.org/10.1007/978-3-319-21744-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-21744-4_2

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-21743-7

  • Online ISBN: 978-3-319-21744-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics