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Sarcoidosis

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Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology

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Abstract

Sarcoidosis is a multisystem, inflammatory disorder of unknown etiology that can affect every organ system in the body [1, 2]. The disease is characterized by the development of non-caseating granulomas, which can cause disease through either active inflammation or scarring and fibrosis. Sarcoidosis occurs worldwide and can affect patients of any race, ethnic group, or age [3]. Patients likely inherit a genetic predisposition for developing the disease, which, coupled with an environmental, infectious, or antigenic exposure, triggers an immune cascade, leading to granulomatous inflammation, which may spontaneously remit, persist, or lead to subsequent fibrosis.

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References

  1. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160(2):736–55.

    Google Scholar 

  2. Costabel U, Hunninghake GW. ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for sarcoidosis and other granulomatous disorders. Eur Respir J. 1999;14(4):735–7.

    Article  CAS  PubMed  Google Scholar 

  3. Siltzbach LE, et al. Course and prognosis of sarcoidosis around the world. Am J Med. 1974;57(6):847–52.

    Article  CAS  PubMed  Google Scholar 

  4. Baughman RP, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1885–9.

    Article  CAS  PubMed  Google Scholar 

  5. Mana J, Marcoval J. Skin manifestations of sarcoidosis. Presse Med. 2012;41(6 Pt 2):e355–74.

    Article  PubMed  Google Scholar 

  6. Judson MA. The diagnosis of sarcoidosis. Clin Chest Med. 2008;29(3):415–27, viii.

    Article  PubMed  Google Scholar 

  7. Judson MA, Baughman RP. How many organs need to be involved to diagnose sarcoidosis? An unanswered question that, hopefully, will become irrelevant. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31:6–7.

    PubMed  Google Scholar 

  8. Hanno R, Callen JP. Sarcoidosis: a disorder with prominent cutaneous features and their interrelationship with systemic disease. Med Clin North Am. 1980;64(5):847–66.

    Article  CAS  PubMed  Google Scholar 

  9. Hanno R, et al. Cutaneous sarcoidal granulomas and the development of systemic sarcoidosis. Arch Dermatol. 1981;117(4):203–7.

    Article  CAS  PubMed  Google Scholar 

  10. Rybicki B, et al. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. 1997;145:234–41.

    Google Scholar 

  11. Rybicki BA, et al. Epidemiology, demographics, and genetics of sarcoidosis. Semin Respir Infect. 1998;13(3):166–73.

    CAS  PubMed  Google Scholar 

  12. Reich JM. A critical analysis of sarcoidosis incidence assessment. Multidiscip Respir Med. 2013;8(1):57.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Mirsaeidi M, et al. Racial difference in sarcoidosis mortality in the United States. Chest. 2015;147(2):438–49.

    Article  PubMed  Google Scholar 

  14. Deng JC, Baughman RP, Lynch JP 3rd. Cardiac involvement in sarcoidosis. Semin Respir Crit Care Med. 2002;23(6):513–27.

    Article  PubMed  Google Scholar 

  15. Hosoda Y, Sasagawa S, Yasuda N. Epidemiology of sarcoidosis: new frontiers to explore. Curr Opin Pulm Med. 2002;8:424–8.

    Article  PubMed  Google Scholar 

  16. Demirkok SS, Basaranoglu M, Akbilgic O. Seasonal variation of the onset of presentations in stage 1 sarcoidosis. Int J Clin Pract. 2006;60(11):1443–50.

    Article  CAS  PubMed  Google Scholar 

  17. Gerke AK, et al. An analysis of seasonality of sarcoidosis in the United States veteran population: 2000–2007. Sarcoidosis Vasc Diffuse Lung Dis. 2012;29(2):155–8.

    CAS  PubMed  Google Scholar 

  18. Gupta D, Agarwal R, Aggarwal AN. Seasonality of sarcoidosis: the ‘heat’ is on. Sarcoidosis Vasc Diffuse Lung Dis. 2013;30(3):241–3.

    PubMed  Google Scholar 

  19. Adrianto I, et al. Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One. 2012;7(8):e43907.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. McGrath DS, et al. Epidemiology of familial sarcoidosis in the UK. Thorax. 2000;55(9):751–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Sverrild A, Backer V, Kyvik KO, et al. Heredity in sarcoidosis: a registry based twin study. Thorax. 2008;63:894–6.

    Article  CAS  PubMed  Google Scholar 

  22. Rossman MD, Kreider ME. Lesson learned from ACCESS (a case controlled etiologic study of sarcoidosis). Proc Am Thorac Soc. 2007;4(5):453–6.

    Article  PubMed  Google Scholar 

  23. Centers for Disease Control and Prevention (CDC). Sarcoidosis among U.S. Navy enlisted men, 1965–1993. Morb Mortal Wkly Rep. 1997;46:539–43.

    Google Scholar 

  24. Prezant DJ, Dhala A, Goldstein A, et al. The incidence and severity of sarcoidosis in New York City Firefighters. Chest. 1999;116:1183–93.

    Article  CAS  PubMed  Google Scholar 

  25. Izbicki G, et al. World Trade Center “sarcoid-like” granulomatous pulmonary disease in New York City Fire Department rescue workers. Chest. 2007;131(5):1414–23.

    Article  PubMed  Google Scholar 

  26. Barnard J, Rose C, Newman L, et al. Job and industry classification associated with sarcoidosis in a case control etiologic study of sarcoidosis. J Occup Environ Med. 2005;47:226–34.

    Article  PubMed  Google Scholar 

  27. Parkes SA, et al. Epidemiology of sarcoidosis in the Isle of Man--1: a case controlled study. Thorax. 1987;42(6):420–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Hills SE, Parkes SA, Baker SB. Epidemiology of sarcoidosis in the Isle of Man--2: evidence for space-time clustering. Thorax. 1987;42(6):427–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Grunewald J, et al. Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. Respir Res. 2010;11:25.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Fischer A, et al. Genetics of sarcoidosis. Semin Respir Crit Care Med. 2014;35(3):296–306.

    Article  PubMed  Google Scholar 

  31. Valentonyte R, et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet. 2005;37(4):357–64.

    Article  CAS  PubMed  Google Scholar 

  32. Feng X, et al. Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study. BMJ Open. 2014;4(7):–e004466.

    Google Scholar 

  33. Fischer A, Rybicki BA. Granuloma genes in sarcoidosis: what is new? Curr Opin Pulm Med. 2015;21(5):510–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Newman KL, Newman LS. Occupational causes of sarcoidosis. Curr Opin Allergy Clin Immunol. 2012;12(2):145–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Chen ES, Moller DR. Etiologies of sarcoidosis. Clin Rev Allergy Immunol. 2015;49(1):6–18.

    Article  CAS  PubMed  Google Scholar 

  36. Clay H, et al. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe. 2007;2(1):29–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Moller DR, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol. 1996;156(12):4952–60.

    CAS  PubMed  Google Scholar 

  38. Shigehara K, et al. IL-12 and IL-18 are increased and stimulate IFN-gamma production in sarcoid lungs. J Immunol. 2001;166(1):642–9.

    Article  CAS  PubMed  Google Scholar 

  39. Facco M, et al. Sarcoidosis is a Th1/Th17 multisystem disorder. Thorax. 2011;66(2):144–50.

    Article  PubMed  Google Scholar 

  40. Shigehara K, et al. Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin Exp Immunol. 2003;132(1):152–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Sones M, Israel HL. Course and prognosis of sarcoidosis. Am J Med. 1960;29(1):84–93.

    Article  CAS  PubMed  Google Scholar 

  42. Miyara M, et al. The immune paradox of sarcoidosis and regulatory T cells. J Exp Med. 2006;203(2):359–70.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Lee N-S, et al. Low levels of NF-κB/p65 mark anergic CD4+ T cells and correlate with disease severity in sarcoidosis. Clin Vaccine Immunol CVI. 2011;18(2):223–34.

    Article  CAS  PubMed  Google Scholar 

  44. Munro CS, Mitchell DN. The K veim response: still useful, still a puzzle. Thorax. 1987;42(5):321–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Morita R, et al. Donor cell-derived sarcoidosis after allogeneic BMT. Bone Marrow Transplant. 2009;43(6):507–8.

    Article  CAS  PubMed  Google Scholar 

  46. Gupta D, et al. Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis. Eur Respir J. 2007;30(3):508–16.

    Article  CAS  PubMed  Google Scholar 

  47. Chen ES, et al. T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis. J Immunol (Baltimore, Md : 1950). 2008;181(12):8784–96.

    Article  CAS  Google Scholar 

  48. Hanngren A, et al. Tuberculostearic acid in lymph nodes from patients with sarcoidosis. Sarcoidosis. 1987;4(2):101–4.

    CAS  PubMed  Google Scholar 

  49. Dubaniewicz A, et al. Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis. J Clin Microbiol. 2006;44(9):3448–51.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Homma JY, et al. Bacteriological investigation on biopsy specimens from patients with sarcoidosis. Jpn J Exp Med. 1978;48(3):251–5.

    CAS  PubMed  Google Scholar 

  51. Eishi Y, et al. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol. 2002;40(1):198–204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Ebe Y, et al. Proliferative response of peripheral blood mononuclear cells and levels of antibody to recombinant protein from Propionibacterium acnes DNA expression library in Japanese patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2000;17(3):256–65.

    CAS  PubMed  Google Scholar 

  53. Chen ES, Moller DR. Etiology of sarcoidosis. Clin Chest Med. 2008;29(3):365–77, vii.

    Article  CAS  PubMed  Google Scholar 

  54. Chen ES, et al. Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2. Am J Respir Crit Care Med. 2010;181(4):360–73.

    Article  CAS  PubMed  Google Scholar 

  55. Bargagli E, et al. Analysis of serum amyloid A in sarcoidosis patients. Respir Med. 2011;105(5):775–80.

    Article  CAS  PubMed  Google Scholar 

  56. Rafnsson V, et al. Association between exposure to crystalline silica and risk of sarcoidosis. Occup Environ Med. 1998;55(10):657–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Werfel U, et al. Sarcoid granulomatosis after zirconium exposure with multiple organ involvement. Eur Respir J. 1998;12(3):750.

    Article  CAS  PubMed  Google Scholar 

  58. Cummings MM, Hudgins PC. Chemical constituents of pine pollen and their possible relationship to sarcoidosis. Am J Med Sci. 1958;236(3):311–7.

    Article  CAS  PubMed  Google Scholar 

  59. Cummings MM. An evaluation of the possible relationship of pine pollen to sarcoidosis. Acta Med Scand. 2009;176:48–50.

    Article  Google Scholar 

  60. Tukiainen P, et al. Pulmonary granulomatous reaction: talc pneumoconiosis or chronic sarcoidosis? Br J Ind Med. 1984;41(1):84–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  61. Farber HW, Fairman RP, Glauser FL. Talc granulomatosis: laboratory findings similar to sarcoidosis. Am Rev Respir Dis. 1982;125(2):258–61.

    CAS  PubMed  Google Scholar 

  62. James DG. A clinicopathological classification of granulomatous disorders. Postgrad Med J. 2000;76(898):457–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Valeyre D, et al. Clinical presentation of sarcoidosis and diagnostic work-up. Semin Respir Crit Care Med. 2014;35(3):336–51.

    Article  PubMed  Google Scholar 

  64. Hillerdal G, et al. Sarcoidosis: epidemiology and prognosis. A 15-year European study. Am Rev Respir Dis. 1984;130(1):29–32.

    CAS  PubMed  Google Scholar 

  65. Johns CJ, et al. Longitudinal study of chronic sarcoidosis with low-dose maintenance corticosteroid therapy. Outcome and complications. Ann N Y Acad Sci. 1986;465:702–12.

    Article  CAS  PubMed  Google Scholar 

  66. Gideon NM, Mannino DM. Sarcoidosis mortality in the United States 1979–1991: an analysis of multiple-cause mortality data. Am J Med. 1996;100(4):423–7.

    Article  CAS  PubMed  Google Scholar 

  67. Perry A, Vuitch F. Causes of death in patients with sarcoidosis. A morphologic study of 38 autopsies with clinicopathologic correlations. Arch Pathol Lab Med. 1995;119(2):167–72.

    CAS  PubMed  Google Scholar 

  68. Takada K, et al. The clinical course and prognosis of patients with severe, moderate or mild sarcoidosis. J Clin Epidemiol. 1993;46(4):359–66.

    Article  CAS  PubMed  Google Scholar 

  69. Iwai K, et al. Racial difference in cardiac sarcoidosis incidence observed at autopsy. Sarcoidosis. 1994;11(1):26–31.

    CAS  PubMed  Google Scholar 

  70. Reich JM, Johnson RE. Course and prognosis of sarcoidosis in a nonreferral setting. Analysis of 86 patients observed for 10 years. Am J Med. 1985;78(1):61–7.

    Article  CAS  PubMed  Google Scholar 

  71. Nunes H, et al. Imaging in sarcoidosis. Semin Respir Crit Care Med. 2007;28(1):102–20.

    Article  PubMed  Google Scholar 

  72. Nishimura K, et al. Pulmonary sarcoidosis: correlation of CT and histopathologic findings. Radiology. 1993;189(1):105–9.

    Article  CAS  PubMed  Google Scholar 

  73. Lynch JP 3rd, Kazerooni EA, Gay SE. Pulmonary sarcoidosis. Clin Chest Med. 1997;18(4):755–85.

    Article  PubMed  Google Scholar 

  74. Wanat KA, Rosenbach M. Cutaneous sarcoidosis. Clin Chest Med. 2015;36(4):685–702.

    Article  PubMed  Google Scholar 

  75. Elgart ML. Cutaneous sarcoidosis: definitions and types of lesions. Clin Dermatol. 1986;4(4):35–45.

    Article  CAS  PubMed  Google Scholar 

  76. Marcoval J, Moreno A, Mana J. Papular sarcoidosis of the knees: a clue for the diagnosis of erythema nodosum-associated sarcoidosis. J Am Acad Dermatol. 2003;49(1):75–8.

    Article  PubMed  Google Scholar 

  77. Elgart ML. Cutaneous lesions of sarcoidosis. Prim Care. 1978;5(2):249–62.

    Article  CAS  PubMed  Google Scholar 

  78. Marcoval J, Mana J, Rubio M. Specific cutaneous lesions in patients with systemic sarcoidosis: relationship to severity and chronicity of disease. Clin Exp Dermatol. 2011;36(7):739–44.

    Article  CAS  PubMed  Google Scholar 

  79. Mana J, et al. Granulomatous cutaneous sarcoidosis: diagnosis, relationship to systemic disease, prognosis and treatment. Sarcoidosis Vasc Diffuse Lung Dis. 2013;30(4):268–81.

    PubMed  Google Scholar 

  80. Ishak R, et al. Cutaneous sarcoidosis: clinicopathologic study of 76 patients from Lebanon. Int J Dermatol. 2015;54(1):33–41.

    Article  PubMed  Google Scholar 

  81. Sharma OP, Papanikolaou IC. Lupus pernio: a tale of four characters in search of a malady. Sarcoidosis Vasc Diffuse Lung Dis. 2009;26(2):167–71.

    CAS  PubMed  Google Scholar 

  82. Spiteri MA, et al. Lupus pernio: a clinico-radiological study of thirty-five cases. Br J Dermatol. 1985;112(3):315–22.

    Article  CAS  PubMed  Google Scholar 

  83. Stagaki E, et al. The treatment of lupus pernio: results of 116 treatment courses in 54 patients. Chest. 2009;135(2):468–76.

    Article  PubMed  Google Scholar 

  84. Yanardag H, Pamuk ON, Pamuk GE. Lupus pernio in sarcoidosis: clinical features and treatment outcomes of 14 patients. J Clin Rheumatol. 2003;9(2):72–6.

    Article  PubMed  Google Scholar 

  85. Efthimiou P, Kukar M. Lupus pernio: sarcoid-specific cutaneous manifestation associated with chronic sarcoid arthropathy. J Clin Rheumatol. 2011;17(6):343.

    Article  PubMed  Google Scholar 

  86. Neville E, et al. Sarcoidosis of the upper respiratory tract and its association with lupus pernio. Thorax. 1976;31(6):660–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Ahmed I, Harshad SR. Subcutaneous sarcoidosis: is it a specific subset of cutaneous sarcoidosis frequently associated with systemic disease? J Am Acad Dermatol. 2006;54(1):55–60.

    Article  PubMed  Google Scholar 

  88. Dalle Vedove C, Colato C, Girolomoni G. Subcutaneous sarcoidosis: report of two cases and review of the literature. Clin Rheumatol. 2011;30(8):1123–8.

    Article  PubMed  Google Scholar 

  89. El Sayed F, Dhaybi R, Ammoury A. Subcutaneous nodular sarcoidosis and systemic involvement successfully treated with doxycycline. 2006;54:42–4.

    Google Scholar 

  90. Higgins EM, Salisbury JR, Du Vivier AW. Subcutaneous sarcoidosis. Clin Exp Dermatol. 1993;18(1):65–6.

    Article  CAS  PubMed  Google Scholar 

  91. Marcoval J, et al. Subcutaneous sarcoidosis--clinicopathological study of 10 cases. Br J Dermatol. 2005;153(4):790–4.

    Article  CAS  PubMed  Google Scholar 

  92. Marcoval J, et al. Subcutaneous sarcoidosis. Dermatol Clin. 2008;26(4):553–6, ix.

    Article  PubMed  Google Scholar 

  93. Marchell RM, Judson MA. Cutaneous sarcoidosis. Semin Respir Crit Care Med. 2010;31(4):442–51.

    Article  PubMed  Google Scholar 

  94. Burgoyne JS, Wood MG. Psoriasiform sarcoidosis. Arch Dermatol. 1972;106(6):896–8.

    Article  CAS  PubMed  Google Scholar 

  95. Wanat KA, et al. Sarcoidosis and psoriasis: a case series and review of the literature exploring co-incidence vs coincidence. JAMA Dermatol. 2013;149(7):848–52.

    Article  PubMed  Google Scholar 

  96. Khalid U, Gislason GH, Hansen PR. Sarcoidosis in patients with psoriasis: a population-based cohort study. PLoS One. 2014;9(10):e109632.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Nishizawa A, et al. Diffuse disseminated lichenoid-type cutaneous sarcoidosis mimicking erythroderma. Int J Dermatol. 2014;53(8):e369–70.

    Article  PubMed  Google Scholar 

  98. Stockman DL, et al. Verrucous cutaneous sarcoidosis: case report and review of this unusual variant of cutaneous sarcoidosis. Am J Dermatopathol. 2013;35(2):273–6.

    Article  PubMed  Google Scholar 

  99. Pezzetta S, et al. Verrucous sarcoidosis of the skin simulating squamous cell carcinoma. Sarcoidosis Vasc Diffuse Lung Dis. 2013;30(1):70–2.

    CAS  PubMed  Google Scholar 

  100. Kelley BP, et al. Ichthyosiform sarcoidosis: a case report and review of the literature. Dermatol Online J. 2010;16(8):5.

    Article  PubMed  Google Scholar 

  101. Yoo SS, et al. Clinicopathologic features of ulcerative-atrophic sarcoidosis. Int J Dermatol. 2004;43(2):108–12.

    Article  PubMed  Google Scholar 

  102. Albertini JG, Tyler W, Miller OF 3rd. Ulcerative sarcoidosis. Case report and review of the literature. Arch Dermatol. 1997;133(2):215–9.

    Article  CAS  PubMed  Google Scholar 

  103. Hall RS, Floro JF, King LE Jr. Hypopigmented lesions in sarcoidosis. J Am Acad Dermatol. 1984;11(6):1163–4.

    Article  CAS  PubMed  Google Scholar 

  104. Yoon CH, Lee C. Erythrodermic form of cutaneous sarcoidosis. Clin Exp Dermatol. 2003;28:575–6.

    Article  CAS  PubMed  Google Scholar 

  105. House NS, Welsh JP, English JC 3rd. Sarcoidosis-induced alopecia. Dermatol Online J. 2012;18(8):4.

    Article  PubMed  Google Scholar 

  106. Santoro F, Sloan SB. Nail dystrophy and bony involvement in chronic sarcoidosis. J Am Acad Dermatol. 2009;60(6):1050–2.

    Article  PubMed  Google Scholar 

  107. Motswaledi MH, et al. Oral sarcoidosis: a case report and review of the literature. Aust Dent J. 2014;59(3):389–94.

    Article  CAS  PubMed  Google Scholar 

  108. Ayyala US, Nair AP, Padilla ML. Cardiac sarcoidosis. Clin Chest Med. 2008;29(3):493–508, ix.

    Article  PubMed  Google Scholar 

  109. Birnie D, et al. Cardiac sarcoidosis. Clin Chest Med. 2015;36(4):657–68.

    Article  PubMed  Google Scholar 

  110. Tavee JO, Stern BJ. Neurosarcoidosis. Clin Chest Med. 2015;36(4):643–56.

    Article  PubMed  Google Scholar 

  111. Pasadhika S, Rosenbaum JT. Ocular sarcoidosis. Clin Chest Med. 2015;36(4):669–83.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Judson MA, et al. Defining organ involvement in sarcoidosis: the ACCESS proposed instrument. ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999;16(1):75–86.

    CAS  PubMed  Google Scholar 

  113. Judson MA, et al. The WASOG sarcoidosis organ assessment instrument: an update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31(1):19–27.

    PubMed  Google Scholar 

  114. Winterbauer RH, Belic N, Moores KD. Clinical interpretation of bilateral hilar adenopathy. Ann Intern Med. 1973;78(1):65–71.

    Article  CAS  PubMed  Google Scholar 

  115. Ball NJ, Kho GT, Martinka M. The histologic spectrum of cutaneous sarcoidosis: a study of twenty-eight cases. J Cutan Pathol. 2004;31(2):160–8.

    Article  PubMed  Google Scholar 

  116. Cardoso JC, et al. Cutaneous sarcoidosis: a histopathological study. J Eur Acad Dermatol Venereol. 2009;23(6):678–82.

    Article  CAS  PubMed  Google Scholar 

  117. Mangas C, et al. Clinical spectrum and histological analysis of 32 cases of specific cutaneous sarcoidosis. J Cutan Pathol. 2006;33(12):772–7.

    Article  PubMed  Google Scholar 

  118. Scadding JG. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br Med J. 1961;2(5261):1165–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Nunes H, Soler P, Valeyre D. Pulmonary sarcoidosis. Allergy. 2005;60(5):565–82.

    Article  CAS  PubMed  Google Scholar 

  120. Costabel U, Guzman J, Baughman RP. Systemic evaluation of a potential cutaneous sarcoidosis patient. Clin Dermatol. 2007;25(3):303–11.

    Article  PubMed  Google Scholar 

  121. Martusewicz-Boros MM, et al. What comorbidities accompany sarcoidosis? A large cohort (n=1779) patients analysis. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32(2):115–20.

    PubMed  Google Scholar 

  122. Kiess AP, et al. Sarcoid in cancer patients: clinical characteristics and associated disease status. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32(3):200–7.

    PubMed  Google Scholar 

  123. Bonifazi M, et al. Sarcoidosis and cancer risk: systematic review and meta-analysis of observational studies. Chest. 2015;147(3):778–91.

    Article  PubMed  Google Scholar 

  124. Chopra A, Judson MA. How are cancer and connective tissue diseases related to sarcoidosis? Curr Opin Pulm Med. 2015;21(5):517–24.

    Article  PubMed  Google Scholar 

  125. Chalayer E, et al. Sarcoidosis and lymphoma: a comparative study. QJM. 2015;108(11):871–8.

    Article  CAS  PubMed  Google Scholar 

  126. Westers-Attema A, et al. Multiple cutaneous squamous cell carcinoma in cutaneous sarcoidosis. J Dermatol. 2015;42(8):845–6.

    Article  PubMed  Google Scholar 

  127. Papadopoulos KI, et al. High frequency of endocrine autoimmunity in patients with sarcoidosis. Eur J Endocrinol. 1996;134(3):331–6.

    Article  CAS  PubMed  Google Scholar 

  128. Nakamura H, et al. High incidence of positive autoantibodies against thyroid peroxidase and thyroglobulin in patients with sarcoidosis. Clin Endocrinol (Oxf). 1997;46(4):467–72.

    Article  CAS  Google Scholar 

  129. Anolik RB, et al. Thyroid dysfunction and cutaneous sarcoidosis. J Am Acad Dermatol. 2012;66(1):167–8.

    Article  PubMed  Google Scholar 

  130. Antonelli A, et al. Prevalence of hypothyroidism and Graves disease in sarcoidosis. Chest. 2006;130(2):526–32.

    Article  PubMed  Google Scholar 

  131. Rajoriya N, et al. Immune-mediated and chronic inflammatory disease in people with sarcoidosis: disease associations in a large UK database. Postgrad Med J. 2009;85(1003):233–7.

    Article  CAS  PubMed  Google Scholar 

  132. Melnick L, et al. Coexistent sarcoidosis and alopecia areata or vitiligo: a case series and review of the literature. J Clin Exp Derm Res. 2014;149(5):236.

    Google Scholar 

  133. Rosenbach M, et al. Reliability and convergent validity of the cutaneous sarcoidosis activity and morphology instrument for assessing cutaneous sarcoidosis. JAMA Dermatol. 2013;149(5):550–6.

    Article  PubMed  Google Scholar 

  134. Baughman RP, et al. Chronic facial sarcoidosis including lupus pernio: clinical description and proposed scoring systems. Am J Clin Dermatol. 2008;9(3):155–61.

    Article  PubMed  Google Scholar 

  135. Yeung H, et al. Reliability and validity of cutaneous sarcoidosis outcome instruments among dermatologists, pulmonologists, and rheumatologists. JAMA Dermatol. 2015;151(12):1317–22.

    Article  PubMed  Google Scholar 

  136. Judson MA, et al. Validation and important differences for the Sarcoidosis Assessment Tool. A new patient-reported outcome measure. Am J Respir Crit Care Med. 2015;191(7):786–95.

    Article  PubMed  Google Scholar 

  137. Victorson DE, et al. A conceptual model of health-related quality of life in sarcoidosis. Qual Life Res. 2014;23(1):89–101.

    Article  PubMed  Google Scholar 

  138. Baughman RP, et al. Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am J Respir Crit Care Med. 2006;174(7):795–802.

    Article  CAS  PubMed  Google Scholar 

  139. Judson MA, et al. Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis. Eur Respir J. 2014;44(5):1296–307.

    Article  CAS  PubMed  Google Scholar 

  140. Baughman RP, et al. Efficacy and safety of apremilast in chronic cutaneous sarcoidosis. Arch Dermatol. 2012;148(2):262–4.

    Article  CAS  PubMed  Google Scholar 

  141. Wanat KA, Rosenbach M. A practical approach to cutaneous sarcoidosis. Am J Clin Dermatol. 2014;15(4):283–97.

    Article  PubMed  Google Scholar 

  142. Khatri KA, Chotzen VA, Burrall BA. Lupus pernio: successful treatment with a potent topical corticosteroid. Arch Dermatol. 1995;131(5):617–8.

    Article  CAS  PubMed  Google Scholar 

  143. Wise RD. Clinical resolution of facial cutaneous sarcoidosis with systemic colchicine and a topical corticosteroid ointment. Compr Ther. 2008;34(2):105–10.

    PubMed  Google Scholar 

  144. Singh SK, Singh S, Pandey SS. Cutaneous sarcoidosis without systemic involvement : response to intralesional corticosteroid. Indian J Dermatol Venereol Leprol. 1996;62(4):273–4.

    Article  CAS  PubMed  Google Scholar 

  145. Marchetti M, Baker MG, Noland MM. Treatment of subcutaneous sarcoidosis with hydroxychloroquine: report of 2 cases. Dermatol Online J. 2014;20:21250.

    Article  PubMed  Google Scholar 

  146. Jones E, Callen JP. Hydroxychloroquine is effective therapy for control of cutaneous sarcoidal granulomas. J Am Acad Dermatol. 1990;23(3 Pt 1):487–9.

    Article  CAS  PubMed  Google Scholar 

  147. Modi S, Rosen T. Micropapular cutaneous sarcoidosis: case series successfully managed with hydroxychloroquine sulfate. Cutis. 2008;81(4):351–4.

    PubMed  Google Scholar 

  148. Zic JA, et al. Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature. Arch Dermatol. 1991;127(7):1034–40.

    Article  CAS  PubMed  Google Scholar 

  149. Miyazaki E, et al. Minocycline for the treatment of sarcoidosis: is the mechanism of action immunomodulating or antimicrobial effect? Clin Rheumatol. 2008;27(9):1195–7.

    Article  PubMed  Google Scholar 

  150. Steen T, English JC. Oral minocycline in treatment of cutaneous sarcoidosis. JAMA Dermatol. 2013;149(6):758–60.

    Article  PubMed  Google Scholar 

  151. Drake WP, et al. Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. JAMA Dermatol. 2013;149(9):1040–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Baughman RP, Judson MA, Ingledue R, et al. Efficacy and safety of apremilast in chronic cutaneous sarcoidosis. Arch Dermatol. 2012;148:262–4.

    Article  CAS  PubMed  Google Scholar 

  153. Zabel P, et al. Pentoxifylline in treatment of sarcoidosis. Am J Respir Crit Care Med. 1997;155(5):1665–9.

    Article  CAS  PubMed  Google Scholar 

  154. Georgiou S, et al. Cutaneous sarcoidosis: complete remission after oral isotretinoin therapy. Acta Derm Venereol. 1998;78(6):457–9.

    Article  CAS  PubMed  Google Scholar 

  155. Baughman RP, Lower EE. Evidence-based therapy for cutaneous sarcoidosis. Clin Dermatol. 2007;25(3):334–40.

    Article  PubMed  Google Scholar 

  156. Doherty CB, Rosen T. Evidence-based therapy for cutaneous sarcoidosis. Drugs. 2008;68(10):1361–83.

    Article  CAS  PubMed  Google Scholar 

  157. Mosam A, Morar N. Recalcitrant cutaneous sarcoidosis: an evidence-based sequential approach. J Dermatolog Treat. 2004;15(6):353–9.

    Article  CAS  PubMed  Google Scholar 

  158. Veien NK, Brodthagen H. Cutaneous sarcoidosis treated with methotrexate. Br J Dermatol. 1977;97(2):213–6.

    Article  CAS  PubMed  Google Scholar 

  159. Vorselaars ADM, et al. Methotrexate vs azathioprine in second-line therapy of sarcoidosis. Chest. 2013;144(3):805–12.

    Article  CAS  PubMed  Google Scholar 

  160. Webster GF, et al. Methotrexate therapy in cutaneous sarcoidosis. Ann Intern Med. 1989;111(6):538–9.

    Article  CAS  PubMed  Google Scholar 

  161. Webster GF, et al. Weekly low-dose methotrexate therapy for cutaneous sarcoidosis. J Am Acad Dermatol. 1991;24(3):451–4.

    Article  CAS  PubMed  Google Scholar 

  162. Droitcourt C, et al. A randomized, investigator-masked, double-blind, placebo-controlled trial on thalidomide in severe cutaneous sarcoidosis. Chest. 2014;146(4):1046–54.

    Article  PubMed  Google Scholar 

  163. Heffernan MP, Anadkat MJ. Recalcitrant cutaneous sarcoidosis responding to infliximab. Arch Dermatol. 2005;141(7):910–1.

    Article  PubMed  Google Scholar 

  164. Meyerle JH, Shorr A. The use of infliximab in cutaneous sarcoidosis. J Drugs Dermatol. 2003;2(4):413–4.

    PubMed  Google Scholar 

  165. Sené T, et al. Infliximab as a steroid-sparing agent in refractory cutaneous sarcoidosis: single-center retrospective study of 9 patients. J Am Acad Dermatol. 2012;66(2):328–32.

    Article  PubMed  Google Scholar 

  166. Tuchinda P, Bremmer M, Gaspari AA. A case series of refractory cutaneous sarcoidosis successfully treated with infliximab. Dermatol Ther. 2012;2(1):11.

    Article  Google Scholar 

  167. Wanat KA, Rosenbach M. Case series demonstrating improvement in chronic cutaneous sarcoidosis following treatment with TNF inhibitors. Arch Dermatol. 2012;148(9):1097–100.

    Article  PubMed  Google Scholar 

  168. Rosen T, Doherty C. Successful long-term management of refractory cutaneous and upper airway sarcoidosis with periodic infliximab infusion. Dermatol Online J. 2007;13(3):14.

    Article  PubMed  Google Scholar 

  169. Field S, et al. Recalcitrant cutaneous sarcoidosis responding to adalimumab but not to etanercept. Clin Exp Dermatol. 2010;35(7):795–6.

    Article  CAS  PubMed  Google Scholar 

  170. Heffernan MP, Smith DI. Adalimumab for treatment of cutaneous sarcoidosis. Arch Dermatol. 2006;142(1):17–9.

    Article  PubMed  Google Scholar 

  171. Pariser RJ, et al. A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis. J Am Acad Dermatol. 2013;68(5):765–73.

    Article  CAS  PubMed  Google Scholar 

  172. Utz JP, et al. Etanercept for the treatment of stage II and III progressive pulmonary sarcoidosis. Chest. 2003;124(1):177–85.

    Article  CAS  PubMed  Google Scholar 

  173. Wijsenbeek MS, Culver DA. Treatment of sarcoidosis. Clin Chest Med. 2015;36(4):751–67.

    Article  PubMed  Google Scholar 

  174. Culver DA. Diagnosing sarcoidosis. Curr Opin Pulm Med. 2015;21(5):499–509.

    Article  PubMed  Google Scholar 

  175. Baughman RP, Lower EE. Treatment of sarcoidosis. Clin Rev Allergy Immunol. 2015;49(1):79–92.

    Article  CAS  PubMed  Google Scholar 

  176. Zhou Y. Organ involvement in 393 consecutive patients seen in one sarcoidosis clinic as measured by the WASOG criteria. Unpublished table in presentation delivered at the American Thoracic Society meeting; 2016.

    Google Scholar 

  177. https://www.medrxiv.org/content/10.1101/2021.07.01.21259700v1.full.pdf

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Authors and Affiliations

  1. Dermatology & Internal Medicine, Cutaneous Sarcoidosis Clinic, University of Pennsylvania, Philadelphia, PA, USA

    Misha Rosenbach

  2. University of Cincinnati Medical Center, Department of Internal Medicine, Cincinnati, OH, USA

    Robert P. Baughman

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  1. Misha Rosenbach
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  2. Robert P. Baughman
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Correspondence to Misha Rosenbach .

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Editors and Affiliations

  1. Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, NY, USA

    Amit Garg

  2. Department of Dermatology Department of Medicine Division of Rheumatology Inflammation and Immunity, Brigham and Women’s Hospital Harvard Medical School, Boston, MA, USA

    Joseph F. Merola

  3. Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, NY, USA

    Laura Fitzpatrick

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Rosenbach, M., Baughman, R.P. (2022). Sarcoidosis. In: Garg, A., Merola, J.F., Fitzpatrick, L. (eds) Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18446-3_9

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