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Extracellular Matrix Alterations and Deposit Formation in AMD

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 854))

Abstract

Age related macular degeneration (AMD) is the primary cause of vision loss in the western world (Friedman et al., Arch Ophthalmol 122:564–572, 2004). The first clinical indication of AMD is the presence of drusen. However, with age and prior to the formation of drusen, extracellular basal deposits accumulate between the retinal pigment epithelium (RPE) and Bruch’s membrane (BrM). Many studies on the molecular composition of the basal deposits and drusen have demonstrated the presence of extracellular matrix (ECM) proteins, complement components and cellular debris. The evidence reviewed here suggests that alteration in RPE cell function might be the primary cause for the accumulation of ECM and cellular debri found in basal deposits. Further studies are obviously needed in order to unravel the specific pathways that lead to abnormal formation of ECM and complement activation.

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Author information

Authors and Affiliations

  1. Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 02114, Boston, MA, USA

    Rosario Fernandez-Godino, Eric A. Pierce & Donita L. Garland

Authors
  1. Rosario Fernandez-Godino
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  2. Eric A. Pierce
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  3. Donita L. Garland
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Corresponding author

Correspondence to Rosario Fernandez-Godino .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  2. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  3. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  4. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  5. Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA

    Joe Hollyfield

  6. Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA

    John Ash

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© 2016 Springer International Publishing Switzerland

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Fernandez-Godino, R., Pierce, E., Garland, D. (2016). Extracellular Matrix Alterations and Deposit Formation in AMD. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_8

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