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Effects of Exercise on Hypertension pp 285–300Cite as

Effects of Exercise on Lipid-Lipoproteins

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Dyslipidemia is a major risk factor for cardiovascular disease, with increasing numbers of adults being treated with cholesterol-lowering drugs (in particular, statin therapy) to treat elevated low-density lipoprotein cholesterol (LDL-C). Both aerobic exercise training and resistance training are efficacious for altering blood lipid levels, with evidence suggesting that aerobic exercise training raises high-density lipoprotein cholesterol (HDL-C) and lowers triglycerides, and resistance training may be more effective at lowering LDL-C. Consequently, concurrent aerobic and resistance training may be the most effective exercise prescription for improving dyslipidemia, although there is a paucity of randomized control trials addressing exercise dose-response for concurrent aerobic and resistance training and lipid-lipoprotein levels. In addition, exercise training may also potentiate the utility of cholesterol-lowering drugs, and there is limited evidence of interactions between exercise and pharmaceutical interventions that favorably impact hypertension and hyperlipidemia in the same individuals. This chapter summarizes evidence for and clinical considerations surrounding the role of exercise training in treating dyslipidemia.

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Abbreviations

ACC:

American College of Cardiology

ACSM:

American College of Sports Medicine

AHA:

American Heart Association

BP:

Blood pressure

CAD:

Coronary artery disease

CHD:

Coronary heart disease

CVD:

Cardiovascular disease

ECS:

European Society of Cardiology

HDL-C:

High density lipoprotein cholesterol

HMG CoA:

Hydroxy-methylglutaryl coenzyme A

LDL-C:

Low density lipoprotein cholesterol

NCEP ATP III:

National Cholesterol Education Program Adult Treatment Panel III

PCSK9:

Proprotein convertase subtilisin/kexin type 9

RAAS:

Renin-angiotensin-aldosterone system

RCT:

Randomized controlled trial

SBP:

Systolic blood pressure

TC:

Total cholesterol

TG:

Triglycerides

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Author information

Authors and Affiliations

  1. Division of Cardiology, Henry Low Heart Center, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06012, USA

    Beth A. Taylor Ph.D., Amanda Zaleski B.S. & Paul D. Thompson M.D.

  2. Department of Kinesiology, College of Agriculture, Health, and Natural Resources, University of Connecticut, 2095 Hillside Rd, U-1110, Storrs, CT, 06269-1110, USA

    Beth A. Taylor Ph.D. & Amanda Zaleski B.S.

  3. University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Paul D. Thompson M.D.

Authors
  1. Beth A. Taylor Ph.D.
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  2. Amanda Zaleski B.S.
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  3. Paul D. Thompson M.D.
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Corresponding author

Correspondence to Beth A. Taylor Ph.D. .

Editor information

Editors and Affiliations

  1. Human Performance Laboratory, University of Connecticut Department of Kinesiology &, Storrs, Connecticut, USA

    Linda S. Pescatello

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Taylor, B.A., Zaleski, A., Thompson, P.D. (2015). Effects of Exercise on Lipid-Lipoproteins. In: Pescatello, L. (eds) Effects of Exercise on Hypertension. Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-17076-3_13

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  • DOI: https://doi.org/10.1007/978-3-319-17076-3_13

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-17075-6

  • Online ISBN: 978-3-319-17076-3

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