Abstract
Biodegradable nanoparticles display high therapeutic potentialities for drug delivery to or through the lungs. However, their interactions with lung cells can be assimilated to the ones described for particulate matter or inorganic manufactured nanoparticles. This is the reason why we discuss in the following chapter, the behavior of nanoparticles towards the different parts of the respiratory tract and the different models and tests that can be carried out to investigate the potential damaging effects of nanoparticles. Taken all together, the different studies using various experimental approaches (in vitro, ex vivo, or in vivo) conclude on no or slight toxicity of nanoparticles intended for nanomedicines.
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Abbreviations
- 7-AAD:
-
7-Aminoactinomycin D
- BAL:
-
Bronchoalveolar lavages
- BALF:
-
Bronchoalveolar lavage fluids
- BALT:
-
Bronchial associated lymphoid tissue
- CLSM:
-
Confocal laser scanning microscopy
- DPI:
-
Dry powder inhaler
- DPPC:
-
1,2-Dipalmitoyl-sn-glycero-3-phosphocholine
- ELISA:
-
Enzyme linked immunosorbent assay
- IL:
-
Interleukin
- IPL:
-
Isolated perfused lung
- LDH:
-
Lactate dehydrogenase
- MDI:
-
Metered dose inhaler
- PEG:
-
Polyethylene glycol
- PLA:
-
Poly(lactic acid)
- PLGA:
-
Poly(lactide-co-glycolide)
- PMN:
-
Polymorphonuclear
- PVA:
-
Polyvinyl alcohol
- RNS:
-
Reactive nitrogen species
- ROS:
-
Reactive oxygen species
- SLN:
-
Solid lipid nanoparticles
- SP:
-
Surfactant proteins
- TEM:
-
Transmission electronic microscopy
- TNF-α:
-
Tumor necrosis factor-α
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Grabowski, N., Hillaireau, H., Vergnaud, J., Fattal, E. (2015). Evaluation of Lung Toxicity of Biodegradable Nanoparticles. In: Devarajan, P., Jain, S. (eds) Targeted Drug Delivery : Concepts and Design. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-11355-5_22
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