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Diabetes Mellitus

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The Perioperative Medicine Consult Handbook

Abstract

Perioperative hyperglycemia increases the risk of infection and other complications. Perioperative control of hyperglycemia with insulin has been shown to nullify this increase even in patients not previously diagnosed as having diabetes (Frisch A, et al. Diabetes Care. 33:1783–8, 2010; Pomposelli JJ, et al. J Parenter Enteral Nutr. 22(2):77–81, 1998; Dellinger EP. Infect Control Hosp Epidemiol. 22:604–6, 2001; Inzucchi SE. N Engl J Med. 355(18):1903–11, 2006; Ramos M, et al. Ann Surg. 248:585–91, 2008; Moghissi ES, et al. Endocrinol Pract. 15(4):1–17, 2009; Kwon S, et al. Ann Surg. 257(1):8–14, 2013; Umpierrez GE, et al. Diabetes Care. 34:256–261, 2011; Kiran RP, et al. Ann Surg. 258(4):599605, 2013). Basal insulin therapy is key to good control, so think in terms of BASAL, BOLUS, and CORRECTION insulin (B-B-C), as shown in Table 13.1. The traditional practice of using only a “sliding scale” for insulin therapy should be abandoned.

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References

  1. Frisch A, et al. Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care. 2010;33:1783–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Pomposelli JJ, Baxter JK, Babineau TJ, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients. J Parenter Enteral Nutr. 1998;22(2):77–81.

    Article  CAS  Google Scholar 

  3. Dellinger EP. Preventing surgical-site infections: the importance of timing and glucose control. Infect Control Hosp Epidemiol. 2001;22:604–6.

    Article  CAS  PubMed  Google Scholar 

  4. Inzucchi SE. Management of hyperglycemia in the hospital setting. N Engl J Med. 2006;355(18):1903–11.

    Article  CAS  PubMed  Google Scholar 

  5. Ramos M, et al. Relationship of perioperative hyperglycemia and postoperative infections in patients who undergo general and vascular surgery. Ann Surg. 2008;248:585–91.

    PubMed  Google Scholar 

  6. Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Endocrinol Pract. 2009;15(4):1–17.

    Google Scholar 

  7. Kwon S, Thompson R, Dellinger P, et al. Importance of perioperative glycemic control in general surgery. Ann Surg. 2013;257(1):8–14.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Umpierrez GE, Smiley D, Jacobs S, et al. Randomized Study of Basal-Bolus Insulin Therapy in the inpatient management of patients with Type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34:256–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kiran RP, Turina M, Hammel J, et al. The clinical significance of an elevated postoperative glucose value in nondiabetic patients after colorectal surgery. Ann Surg. 2013;258(4):599605.

    Google Scholar 

  10. Hirsch IB. Sliding scale insulin-time to stop sliding. JAMA. 2009;301(2):213–4.

    Article  CAS  PubMed  Google Scholar 

  11. Perna M, Romagnuolo J, Morgan K, et al. Preoperative hemoglobinA1c and postoperative glucose control in outcomes after gastric bypass for obesity. Surg Obesity Rel Dis. 2012;8(6):685–90.

    Article  Google Scholar 

  12. Wright LAC, Hirsch IB. The challenge of the use of glycemic biomarkers in diabetes: Reflecting on hemoglobin A1C, 1,5-anhydroglucitol, and the glycated proteins fructosamine and albumin. Diabetes Spectrum. 2012;25:141–8.

    Article  Google Scholar 

  13. The NICE-Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97.

    Article  Google Scholar 

  14. Inzucchi SE, Siegle MD. Glucose control in the ICU—how tight is too tight? N Engl J Med. 2009;360(13):1346–9.

    Article  CAS  PubMed  Google Scholar 

  15. Griesdale DE, de Souza RJ, van Dam RM, et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including the NICE-SUGAR study data. CMAJ. 2009;180(8):821–7.

    Article  PubMed  Google Scholar 

  16. Joint Statement from ADA and AACE on the NICE-SUGAR study on intensive versus conventional glucose control in critically ill patients. https://www.aace.com/files/inpatientglycemiccontrolconsensusstatement.pdf. Accessed 22 Oct 2014.

  17. Kasangara D, et al. Intensive insulin therapy in hospitalized patients: a systematic review. Ann Intern Med. 2011;154:268–82.

    Article  Google Scholar 

  18. Umpierrez GE, Hellman R, Korytkowski MT, Kosiborod M, Maynard GA, Montori VM, Seley JJ, Van den Berghe G. Endocrine society. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38.

    Article  CAS  PubMed  Google Scholar 

  19. Lipska KJ, et al. Use of metformin in the setting of mild to moderate renal insufficiency. Diabetes Care. 2011;34(6):1431–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Nason P. Hamlin M.D. .

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Hamlin, N.P., Mitchell, K.J. (2015). Diabetes Mellitus. In: Jackson, M.B., Mookherjee, S., Hamlin, N.P. (eds) The Perioperative Medicine Consult Handbook. Springer, Cham. https://doi.org/10.1007/978-3-319-09366-6_13

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  • DOI: https://doi.org/10.1007/978-3-319-09366-6_13

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