Abstract
The morphology of drugs’ nanocarriers could be considered as their think tank, and can be correlated with their functionality, which is mainly shuttled on their surface in which most of the interactions and interfacial phenomena are occurred. In our point of view, the gold standard technique for characterizing the morphology of nanoparticles could be the fractal analysis. From the experimental point of view, the determined fractal dimension illustrates in a comprehensive way the self-assembly and the morphological complexity of conventional and chimeric liposomal drug nanocarriers [1–5].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pippa N, Kaditi E, Pispas S, Demetzos C (2013) PEO-b-PCL/DPPC chimeric nanocarriers: self-assembly aspects in aqueous and biological media and drug incorporation. Soft Matter 9:4073
Pippa N, Merkouraki M, Pispas S, Demetzos C (2013) DPPC:MPOx chimeric advanced Drug Delivery nanosystems (chi-aDDnSs): physicochemical and structural characterization, stability and drug release studies. Int J Pharm 450(1–2):1
Pippa N, Kaditi E, Pispas S, Demetzos C (2013) DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers. J Nanopart Res 15:1685
Pippa N, Psarommati F, Pispas S, Demetzos C (2013) The shape/morphology balance: a study of stealth liposomes via fractal analysis and drug encapsulation. Pharm Res 30(9):2385
Pippa N, Dokoumetzidis A, Demetzos C, Macheras P (2013) On the ubiquitous presence of fractals and fractal concepts in pharmaceutical sciences: a review. Int J Pharm 456:340
Pippa N, Gardikis K, Pispas S, Demetzos C (2014) The physicochemical/thermodynamic balance of advanced drug liposomal delivery systems. J Therm Anal Calorim 116:99–105
Demetzos C, Pippa N (2014) Advanced drug delivery nano systems (aDDnSs): a mini-review. Drug Deliv 21:250
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Demetzos, C., Pippa, N. (2015). The Fractal Analysis as a Complementary Approach to Predict the Stability of Drug Delivery nano Systems (DDnSs) in Aqueous and Biological Media: A Regulatory Proposal or a Dream?. In: Vlamos, P., Alexiou, A. (eds) GeNeDis 2014. Advances in Experimental Medicine and Biology, vol 822. Springer, Cham. https://doi.org/10.1007/978-3-319-08927-0_27
Download citation
DOI: https://doi.org/10.1007/978-3-319-08927-0_27
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08926-3
Online ISBN: 978-3-319-08927-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)