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The Chemokine (C-C Motif) Ligand 2 in Neuroinflammation and Neurodegeneration

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Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 824))

Abstract

Among all the chemokines known so far, chemokine (C-C motif) ligand 2 (CCL2) is probably the best characterized. This is mainly due to the therapeutic potential attributed to its regulation. The suppression of CCL2 function may reduce the attraction of immune cells to the sites of inflammation and therefore slow down the progression of inflammation and the tissue damage that may be associated to it. While this has proven to be right in diverse conditions, it has also been described to have deleterious consequences such as a dual effect that is also frequently observed in other endogenous defense systems. This review discusses current knowledge about CCL2 involvement in different neurodegenerative diseases as well as its anti-inflammatory and neuro-protective actions.

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Acknowledgements

This work was supported by a grant from the Spanish Ministry of Science and Innovation (SAF2010-21948) to JLMM.

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Authors and Affiliations

  1. Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Hospital 12 de Octubre (Imas12), Instituto de Investigación en Neuroquímica UCM, Avda. Complutense s/n, Madrid, 28040, Spain

    José L. M. Madrigal

  2. Departamento de Psiquiatría, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Hospital 12 de Octubre (Imas12), Instituto de Investigación en Neuroquímica UCM, Madrid, Spain

    Javier R. Caso

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  1. José L. M. Madrigal
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Correspondence to José L. M. Madrigal .

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  1. Hospital Universitari de Sant Joan, IISPV, URV, Unitat de Recerca Biomèdica, Reus, Spain

    Jordi Camps

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Madrigal, J.L.M., Caso, J.R. (2014). The Chemokine (C-C Motif) Ligand 2 in Neuroinflammation and Neurodegeneration. In: Camps, J. (eds) Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics. Advances in Experimental Medicine and Biology, vol 824. Springer, Cham. https://doi.org/10.1007/978-3-319-07320-0_15

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