Abstract
In order to optimize outcomes following pediatric liver transplantation, clinicians must take a dual approach: (1) to prevent complications and (2) to successfully salvage patients after complications occur. In this chapter, the latter is addressed through understanding the utility of “failure to rescue” in perioperative quality improvement and specific strategies to address the most common complications in this population. Failure to rescue, a measure of a center’s ability to recognize quickly and effectively manage complications, is defined as mortality following a severe complication, and there is an increasing evidence to suggest its importance in efforts to improve outcomes following major surgery. The core tenets of successful rescue include early diagnosis and effective rescue. Hospital-level factors including team structure and communication and access to resources such as intensive care units and emergency operating rooms are essential to the ability to salvage a patient following complications. Strategies to enhance these aspects are discussed for common and morbid complications following this operation, including vascular complications, biliary tract complications, graft failure, and sepsis. By addressing the period after a complication occurs, clinicians can address disparities in the ability to rescue pediatric liver transplant patients and intervene on a period critical to optimizing outcomes.
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References
(2007) Sentinel event statistics – Oct 2007. The Joint Commission. Retrieved 15 Dec 2015, from http://www.jointcommission.org/sentinel_event.aspx
Aggarwal R, Undre S, Moorthy K, Vincent C, Darzi A (2004) The simulated operating theatre: comprehensive training for surgical teams. Qual Saf Health Care 13(Suppl 1):i27–i32
AHRQ quality indicators: patient safety indicators, technical specifications, National Quality Forum. NQF-endorsed standards: measure 0353: failure to rescue 30-day mortality (risk adjusted). http://www.qualityforum.org/QPS/0353. Accessed 1 Sept 2015.
Awad SS, Fagan SP, Bellows C, Albo D, Green-Rashad B, De la Garza M, Berger DH (2005) Bridging the communication gap in the operating room with medical team training. Am J Surg 190(5):770–774
Boraschi P, Donati F (2014) Postoperative biliary adverse events following orthotopic liver transplantation: assessment with magnetic resonance cholangiography. World J Gastroenterol 20(32):11080–11094
Cima RR, Kollengode A, Storsveen AS, Weisbrod CA, Deschamps C, Koch MB, Moore D, Pool SR (2009) A multidisciplinary team approach to retained foreign objects. Jt Comm J Qual Patient Saf 35(3):123–132
Cramm SL, et al. (2016) Failure to rescue as a quality improvement approach in transplantation: A first effort to evaluate this tool in pediatric liver transplantation. Transplantation 100(4):801–807
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving S, Sepsis Campaign Guidelines Committee including the Pediatric (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41(2):580–637
Elgend HM, El Moghazy WM, Uemoto S, Fukuda K (2012) Pre transplant serum magnesium level predicts outcome after pediatric living donor liver transplantation. Ann Transplant 17(2):29–37
Englesbe MJ, Kelly B, Goss J, Fecteau A, Mitchell J, Andrews W, Krapohl G, Magee JC, Mazariegos G, Horslen S, Bucuvalas J (2012) Reducing pediatric liver transplant complications: a potential roadmap for transplant quality improvement initiatives within north America. Am J Transplant 12(9):2301–2306
Farjah F, Backhus L, Cheng A, Englum B, Kim S, Saha-Chaudhuri P, Wood DE, Mulligan MS, Varghese TK (2015) Failure to rescue and pulmonary resection for lung cancer. J Thorac Cardiovasc Surg 149(5):1365–1371, discussion 1371–1363 e1363
Gawande AA, Zinner MJ, Studdert DM, Brennan TA (2003) Analysis of errors reported by surgeons at three teaching hospitals. Surgery 133(6):614–621
Ghaferi AA, Dimick JB (2012) Variation in mortality after high-risk cancer surgery: failure to rescue. Surg Oncol Clin N Am 21(3):389–395, vii
Ghaferi AA, Birkmeyer JD, Dimick JB (2009) Complications, failure to rescue, and mortality with major inpatient surgery in medicare patients. Ann Surg 250(6):1029–1034
Ghaferi AA, Osborne NH, Birkmeyer JD, Dimick JB (2010) Hospital characteristics associated with failure to rescue from complications after pancreatectomy. J Am Coll Surg 211(3):325–330
Gillespie BM, Chaboyer W, Murray P (2010) Enhancing communication in surgery through team training interventions: a systematic literature review. AORN J 92(6):642–657
Greif F, Bronsther OL, Van Thiel DH, Casavilla A, Iwatsuki S, Tzakis A, Todo S, Fung JJ, Starzl TE (1994) The incidence, timing, and management of biliary tract complications after orthotopic liver transplantation. Ann Surg 219(1):40–45
Grenda TR, Revels SL, Yin H, Birkmeyer JD, Wong SL (2015) Lung cancer resection at hospitals with high vs low mortality rates. JAMA Surg 150:1034–1040
Gu LH, Fang H, Li FH, Zhang SJ, Han LZ, Li QG (2015) Preoperative hepatic hemodynamics in the prediction of early portal vein thrombosis after liver transplantation in pediatric patients with biliary atresia. Hepatobiliary Pancreat Dis Int 14(4):380–385
Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MC, Merry AF, Moorthy K, Reznick RK, Taylor B, Gawande AA, Safe Surgery Saves Lives Study Group (2009) A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med 360(5):491–499
Helme E, Brodrick R, Loveridge R (2015) Tracking failure to rescue in the future hospital. Clin Med 15(Suppl 3):s4
Johnston MJ, Arora S, King D, Bouras G, Almoudaris AM, Davis R, Darzi A (2015) A systematic review to identify the factors that affect failure to rescue and escalation of care in surgery. Surgery 157(4):752–763
Joseph B, Zangbar B, Khalil M, Kulvatunyou N, Haider AA, O’Keeffe T, Tang A, Vercruysse G, Friese RS, Rhee P (2015) Factors associated with failure-to-rescue in patients undergoing trauma laparotomy. Surgery 158(2):393–398
Kochhar G, Parungao JM, Hanouneh IA, Parsi MA (2013) Biliary complications following liver transplantation. World J Gastroenterol 19(19):2841–2846
Laurence JM, Sapisochin G, DeAngelis M, Seal JB, Miserachs MM, Marquez M, Zair M, Fecteau A, Jones N, Hrycko A, Avitzur Y, Ling SC, Ng V, Cattral M, Grant D, Kamath BM, Ghanekar A (2015) Biliary complications in pediatric liver transplantation: incidence and management over a decade. Liver Transpl 21(8):1082–1090
Lehman KD, Thiessen K (2015) Sepsis guidelines: clinical practice implications. Nurse Pract 40(6):1–6
Martin SR, Atkison P, Anand R, Lindblad AS, SPLIT Research Group (2004) Studies of Pediatric Liver Transplantation 2002: patient and graft survival and rejection in pediatric recipients of a first liver transplant in the United States and Canada. Pediatr Transplant 8(3):273–283
McDiarmid SV, Anand R, Martz K, Millis MJ, Mazariegos G (2011) A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. Ann Surg 254(1):145–154
Pascher A, Neuhaus P (2006) Biliary complications after deceased-donor orthotopic liver transplantation. J Hepatobiliary Pancreat Surg 13(6):487–496
Renz JF, Yersiz H, Reichert PR, Hisatake GM, Farmer DG, Emond JC, Busuttil RW (2003) Split-liver transplantation: a review. Am J Transplant 3(11):1323–1335
Rhodes A, Phillips G, Beale R, Cecconi M, Chiche JD, De Backer D, Divatia J, Du B, Evans L, Ferrer R, Girardis M, Koulenti D, Machado F, Simpson SQ, Tan CC, Wittebole X, Levy M (2015) The surviving sepsis campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Med 41(9):1620–1628
Rogers SO Jr, Gawande AA, Kwaan M, Puopolo AL, Yoon C, Brennan TA, Studdert DM (2006) Analysis of surgical errors in closed malpractice claims at 4 liability insurers. Surgery 140(1):25–33
Santschi M, Leclerc F, members of the Reseau Mere-Enfant de la Francophonie (2013) Management of children with sepsis and septic shock: a survey among pediatric intensivists of the Reseau Mere-Enfant de la Francophonie. Ann Intensive Care 3(1):7
Shaked A, Vargas J, Csete ME, Kiai K, Jurim O, Colquhoun S, McDiarmid SV, Ament ME, Busuttil RW (1993) Diagnosis and treatment of bowel perforation following pediatric orthotopic liver transplantation. Arch Surg 128(9):994–998, discussion 998–999
Sheetz KH, Dimick JB, Ghaferi AA (2014) The association between hospital care intensity and surgical outcomes in medicare patients. JAMA Surg 149(12):1254–1259
Sheetz KH, Dimick JB, Ghaferi AA (2016) Impact of hospital characteristics on failure to rescue following major surgery. Ann Surg 263:692–697
Silber JH, Williams SV, Krakauer H, Schwartz JS (1992) Hospital and patient characteristics associated with death after surgery. A study of adverse occurrence and failure to rescue. Med Care 30(7):615–629
Silber JH, Rosenbaum PR, Romano PS, Rosen AK, Wang Y, Teng Y, Halenar MJ, Even-Shoshan O, Volpp KG (2009) Hospital teaching intensity, patient race, and surgical outcomes. Arch Surg 144(2):113–120, discussion 121
Spada M, Riva S, Maggiore G, Cintorino D, Gridelli B (2009) Pediatric liver transplantation. World J Gastroenterol 15(6):648–674
Spolverato G, Ejaz A, Hyder O, Kim Y, Pawlik TM (2014) Failure to rescue as a source of variation in hospital mortality after hepatic surgery. Br J Surg 101(7):836–846
Thompson GC, Macias CG (2015) Recognition and management of sepsis in children: practice patterns in the emergency department. J Emerg Med 49:391–399
Underwood PW, Cron DC, Terjimanian MN, Wang SC, Englesbe MJ, Waits SA (2015) Sarcopenia and failure to rescue following liver transplantation. Clin Transplant 29(12):1076–1080
Varghese TK Jr (2015) Failure to rescue metric in lung surgery: a needed breath of fresh air. JAMA Surg 150(11):1040–1041
Waits SA, Sheetz KH, Campbell DA, Ghaferi AA, Englesbe MJ, Eliason JL, Henke PK (2014) Failure to rescue and mortality following repair of abdominal aortic aneurysm. J Vasc Surg 59(4):909–914 e901
Yersiz H, Renz JF, Farmer DG, Hisatake GM, McDiarmid SV, Busuttil RW (2003) One hundred in situ split-liver transplantations: a single-center experience. Ann Surg 238(4):496–505, discussion 506–497
Zoepf T, Maldonado-Lopez EJ, Hilgard P, Dechene A, Malago M, Broelsch CE, Schlaak J, Gerken G (2005) Diagnosis of biliary strictures after liver transplantation: which is the best tool? World J Gastroenterol 11(19):2945–2948
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Cramm, S.L., Englesbe, M.J., Magee, J.C. (2018). Opportunities for Salvage for Optimizing Ideal Outcomes. In: Dunn, S., Horslen, S. (eds) Solid Organ Transplantation in Infants and Children. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07284-5_13
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