Abstract
There are many applications in pharmacokinetic described and modelled by linear or non-linear differential equation systems. These non-linarities can be considered in pharmacokinetic model parameters and the pharmacokinetics of drug action. The Euler’s- and Taylor’s expansion methods are applied for numerical solution pharmacokinetic equations. A fictitious exciting functions method makes possible numerical solution of this DE system with non-stationary matrices. The solutions of warfarin target-mediated drug disposition are presented as well.
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Gombárska, D., Beňová, M. (2014). Euler’s and Taylor’s Expansion Method Applied on Non-linear Pharmacokinetics Model. In: Piętka, E., Kawa, J., Wieclawek, W. (eds) Information Technologies in Biomedicine, Volume 3. Advances in Intelligent Systems and Computing, vol 283. Springer, Cham. https://doi.org/10.1007/978-3-319-06593-9_32
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DOI: https://doi.org/10.1007/978-3-319-06593-9_32
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-06592-2
Online ISBN: 978-3-319-06593-9
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