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Doppler Optical Coherence Tomography

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Optical Coherence Tomography

Abstract

Noninvasive techniques for imaging in vivo blood flow are of great value to biomedical research and clinical diagnostics where many diseases have a vascular etiology or component. In ophthalmology, many diseases involve disturbances in ocular blood flow, including diabetic retinopathy, low tension glaucoma, anterior ischemic optic neuritis, and macular degeneration. Simultaneous imaging of tissue structure and blood flow could provide critical information for early diagnosis of ocular diseases.

This chapter describes Doppler OCT, an imaging modality that combines Doppler principles with OCT to image tissue structure and blood flow velocity simultaneously. Since the first demonstration of Doppler OCT in 1997, significant advances have been made to translate the technology from bench-side to clinical applications. The development of phase-resolved methods and Fourier domain technique has significantly increased imaging speed and velocity sensitivity, and has enabled real-time imaging of tissue microcirculation.

We will review the advances in Doppler OCT over the last eighteen years. Several variation of Doppler OCT techniques, such as phase variation and intensity variation methods, will be compared. The recent applications of Doppler OCT for quantifying blood flow, mapping retinal and choroidal microcirculation, and evaluating mechanical properties with optical coherence elastography will be discussed.

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Acknowledgments

We would like to thank many of our colleagues who have contributed to the Doppler OCT project at the Beckman Laser Institute and Department of Biomedical Engineering at UCI, particularly the students and postdoctoral fellows. Dr. Chen also wants to acknowledge grants support from the National Institutes of Health (R01EB-10090, R01EY-021529, R01HL-105215, R01HL-125084, and P41EB-015890), Air Force Office of Scientific Research (FA9550-04-0101), and the Beckman Laser Institute Endowment.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Beckman Laser Institute, University of California Irvine, Irvine, CA, 92612, USA

    Zhongping Chen

  2. The Edwards Life Sciences Center for Advanced Cardiovascular Technology, Beckman Laser Institute, Irvine, CA, USA

    Zhongping Chen

  3. Department of Biomedical Engineering, The Beckman Laser Institute, University of California Irvine, Irvine, CA, 92612, USA

    Jun Zhang

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  1. Zhongping Chen
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  2. Jun Zhang
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Correspondence to Zhongping Chen .

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Editors and Affiliations

  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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© 2015 Springer International Publishing Switzerland

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Chen, Z., Zhang, J. (2015). Doppler Optical Coherence Tomography. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_42

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