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Ultrahigh Speed OCT

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Optical Coherence Tomography

Abstract

Optical coherence tomography (OCT) is an imaging modality that can generate micrometer resolution, two-dimensional cross-sectional images and three-dimensional volumetric data on the internal structure of optically scattering and reflective tissues and materials. The development of Fourier-domain detection enabled a breakthrough in OCT imaging sensitivity and speed, and the newest generation of OCT is based on wavelength swept light sources (Swept source / Fourier-domain OCT; SS-OCT). We describe high imaging speed and long depth range SS-OCT with an emphasis on SS-OCT technology using MEMS-tunable vertical cavity surface-emitting lasers operating at 1,050 nm and 1,310 nm. We also review representative applications using adjustable high speed and long range SS-OCT including ophthalmic imaging (retinal, anterior segment and full eye length imaging), optical coherence microscopy, endoscopy, ocular biometry, metrology, profilometry and non-destructive material evaluation.

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Acknowledgements

The authors thank Osman Ahsen, WooJhon Choi, Dr. Al-Hafeez Dhalla, ByungKun Lee, Hsiang-Chieh Lee, Chen D. Lu, Kathrin Mohler, Dr. Yuankai Tao, and Dr. Tsung-Han Tsai from the Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics at the Massachusetts Institute of Technology; Dr. David Huang from Oregon Health and Science University; Dr. Jay S. Duker, Mehreen Ahdi, and Jason Y. Zhang from the New England Eye Center at the Tufts University; Dr. Bernhard Baumann from Medical University of Vienna; Dr. Joachim Hornegger and Martin F. Kraus from University of Erlangen; and Dr. James Jiang from Thorlabs Inc. The studies were supported by the National Institutes of Health (R01-EY011289-27, R01-EY013178-12, R01-EY018184-05, R01-CA075289-16, R01-EY019029-03, R01-NS057476-05, R44-CA101067-05, R44-EY022864-01) and the Air Force Office for Scientific Research (FA9550-10-1-0551, FA9550-10-1-0063, FA9550-12-1-0499).

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  1. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Cambridge, 02139, MA, USA

    Ireneusz Grulkowski, Jonathan J. Liu, Benjamin Potsaid & James G. Fujimoto

  2. Advanced Imaging Group, Thorlabs Inc., 56 Sparta Avenue, Newton, NJ, 07860, USA

    Benjamin Potsaid & Alex E. Cable

  3. Praevium Research Inc., 5266 Hollister Avenue, Santa Barbara, Santa Barbara, 93111, CA, USA

    Vijaysekhar Jayaraman

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  1. Ireneusz Grulkowski
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  2. Jonathan J. Liu
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  4. Vijaysekhar Jayaraman
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  5. Alex E. Cable
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  6. James G. Fujimoto
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Correspondence to Ireneusz Grulkowski .

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  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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Grulkowski, I., Liu, J.J., Potsaid, B., Jayaraman, V., Cable, A.E., Fujimoto, J.G. (2015). Ultrahigh Speed OCT. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_11

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