Abstract
Living donor intestinal transplantation (LDIT) has been perfected in relation to technical details, leading to results comparable to those obtained with deceased donors. Because the availability of adequate supply of intestinal deceased grafts, LDIT should be limited to specific indications. In particular, the best indication is probably combined living donor intestinal/liver transplantation (CLDILT) in pediatric recipients with intestinal and hepatic failure. In this setting, the virtual elimination of waiting time may avoid the high mortality currently experienced by candidates on the deceased waiting list. Isolated LDIT may be indicated for candidates to intestinal transplantation with lack of central venous access as a rapid rescue strategy. Potentially, LDIT could be also used in highly sensitized recipients to allow the application of desensitization protocols. Finally, in the specific case of available identical twins or HLA-identical sibling, LDIT has a significant immunological advantage and should be offered.
This is a preview of subscription content, log in via an institution to check access.
References
Alican F et al (1971) Intestinal transplantation: laboratory experience and report of a clinical case. Am J Surg 121(2):150–159. ISSN 0002-9610
Benedetti E et al (1995) Simultaneous en bloc transplantation of liver, small bowel and large bowel in pigs-technical aspects. Transplant Proc 27(1):341–343. ISSN 0041-1345
Boggi U et al (2012) Laparoscopic robot-assisted pancreas transplantation: first world experience. Transplantation 93(2):201–206. ISSN 1534-6080
Deltz E et al (1989) First successful clinical small intestine transplantation. Tactics and surgical technic. Chirurg 60(4):235–239. ISSN 0009-4722
Deltz E, Mengel W, Hamelmann H (1990) Small bowel transplantation: report of a clinical case. Prog Pediatr Surg 25:90–96. ISSN 0079-6654
Fortner JG et al (1972) Immunological responses to an intestinal allograft with HL-A-identical donor-recipient. Transplantation 14(5):531–535. ISSN 0041-1337
Gangemi A et al (2009) Lessons learned in pediatric small bowel and liver transplantation from living-related donors. Transplantation 87(7):1027–1030. ISSN 1534-6080
Garcia-Roca R et al (2016) Successful living donor intestinal transplantation in cross-match positive recipients: Initial experience. World J Gastrointest Surg 8(1):101–105
Ghafari J et al (2012) The effect of small bowel living donation on donor lipid profile. Transpl Int 25(1):e19–e20. ISSN 1432-2277
Goulet O, Ruemmele F (2006) Causes and management of intestinal failure in children. Gastroenterology 130(2 Suppl 1):S16–S28. ISSN 0016-5085
Gruessner RWG, Benedetti E (2008) Living donor organ transplantation. McGraw Hill professional. McGraw-Hill Medical, New York, 1 online resource, p 2008.
Gruessner RW, Sharp HL (1997) Living-related intestinal transplantation: first report of a standardized surgical technique. Transplantation 64(11):1605–1607. ISSN 0041-1337
Halme L et al (1997) Is obesity still a risk factor in renal transplantation? Transpl Int 10(4):284–288. ISSN 0934-0874
Howard L et al (1995) Current use and clinical outcome of home parenteral and enteral nutrition therapies in the United States. Gastroenterology 109(2):355–365. ISSN 0016-5085
Ishii T et al (2006) Two cases of living-related intestinal transplantation. Transplant Proc 38(6):1687–1688. ISSN 0041-1345
Kelly DA (1998) Liver complications of pediatric parenteral nutrition—epidemiology. Nutrition 14(1):153–157. ISSN 0899-9007
Kumaran V et al (2012) Living donor intestinal transplant using a standardized technique: first report from India. Indian J Gastroenterol 31(4):179–185. ISSN 0975-0711
Langnas AN (2004) Advances in small-intestine transplantation. Transplantation 77(9 Suppl):S75–S78. ISSN 0041-1337
Lee MD et al (2004) Isolated small bowel transplantation from a living-related donor at the Catholic University of Korea: a case report of rejection -free course. Yonsei Med J 45(6):1198–1202. ISSN 0513-5796
Morris JA et al (1995) Identical-twin small-bowel transplant for desmoid tumour. Lancet 345(8964):1577–1578. ISSN 0140-6736
Pollard SG et al (1996) Living related small bowel transplantation: the first United Kingdom case. Transplant Proc 28(5):2733. ISSN 0041-1345
Reyes J et al (2005) Intestinal transplantation under tacrolimus monotherapy after perioperative lymphoid depletion with rabbit anti-thymocyte globulin (thymoglobulin). Am J Transplant 5(6):1430–1436. ISSN 1600-6135
Stratta P et al (2012) The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation. Eur J Clin Pharmacol 68(5):671–680. ISSN 1432-1041
Sudan D (2006) Cost and quality of life after intestinal transplantation. Gastroenterology 130(2 Suppl 1):S158–S162. ISSN 0016-5085
Testa G et al (2008) Simultaneous or sequential combined living donor-intestine transplantation in children. Transplantation 85(5):713–717. ISSN 0041-1337
Uemoto S et al (1998) Living-related small bowel transplantation: the first case in Japan. Pediatr Transplant 2(1):40–44. ISSN 1397-3142
Ueno T, Fukuzawa M (2010) Current status of intestinal transplantation. Surg Today 40(12):1112–1122. ISSN 1436-2813
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this entry
Cite this entry
Tzvetanov, I., D’Amico, G., Benedetti, E. (2017). Live Donor Intestinal Transplantation. In: Shah, A., Doria, C. (eds) Contemporary Small Bowel Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-05547-3_18-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-05547-3_18-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-05547-3
Online ISBN: 978-3-319-05547-3
eBook Packages: Springer Reference MedicineReference Module Medicine