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Contemporary Liver Transplantation pp 1–18Cite as

Fulminant Hepatic Failure: Diagnosis and Management

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Abstract

Fulminant hepatic failure (FHF) is a condition resulting in rapid deterioration of liver function often followed by a cascade of fatal consequences. This rare syndrome is incited by a catastrophic insult to the liver. The causes of FHF can be classified into six general categories: viral infections, drugs and toxins, and cardiovascular, metabolic, miscellaneous, and indeterminate causes. FHF can result in sudden onset of hepatic encephalopathy, coagulopathy, jaundice, and multisystem organ failure. An improvement in the morbidity and mortality associated with FHF has been seen over the last several years with an advanced understanding of the mechanisms of injury, early initiation of intensive medical therapy, and the use of orthotopic liver transplant. This chapter will review the topic of FHF with a focus on the etiologies and clinical management.

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  1. Division of Gastroenterology and Hepatology, Sidney Kimmel Medical College at Thomas Jefferson University, 132 S. 10th Street, Main Building, Suite 480, Philadelphia, PA, 19107, USA

    Dina L. Halegoua-De Marzio & David A. Sass

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  1. Dina L. Halegoua-De Marzio
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  2. David A. Sass
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Correspondence to David A. Sass .

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  1. Jefferson Liver Tumor Center Division of Transplantation, Thomas Jefferson University Hospital Kimmel Cancer Center, Philadelphia, Pennsylvania, USA

    Cataldo Doria

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Marzio, D.L.HD., Sass, D.A. (2016). Fulminant Hepatic Failure: Diagnosis and Management. In: Doria, C. (eds) Contemporary Liver Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-05543-5_16-2

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  1. Latest

    Fulminant Hepatic Failure: Diagnosis and Management
    Published:
    24 September 2016

    DOI: https://doi.org/10.1007/978-3-319-05543-5_16-2

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    Fulminant Hepatic Failure: Diagnosis and Management
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    24 February 2015

    DOI: https://doi.org/10.1007/978-3-319-05543-5_16-1

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