Summary
In vitamin B6 deficient rats the nuclear uptake and retention of oestradiol in the uterus and of testosterone in the prostate was greater and more prolonged than in vitamin B6 supplemented controls. This was accompanied by enhancement of the sensitivity of target tissues to steroid hormone action. In ovariectomised females there was more marked suppression of LH secretion and induction of uterine peroxidase by low doses of ethynyl oestradiol in deficient animals. In castrated male rats maintained on low doses of testosterone, the rate of prostate growth and the prostate mitotic index were significantly greater in vitamin B6 deficiency.
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References
Bowden, J-F., Bender, D.A., Coulson, W.F. and Symes, E.K. (1986) J. Ster. Biochem. 25, 359–365.
Cidlowski, J.A. and Thanassi, J.W. (1981) J. Ster. Biochem. 15, 11–16.
Symes, E.K., Bender, D.A., Bowden, J-F. and Coulson, W.F. (1984) J. Ster. Biochem. 20, 1089–1093.
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© 1987 Birkhäuser Verlag Basel
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Bender, D.A., Bowden, JF., Coulson, W.F., Dewji, M.R., Sutton, J., Symes, E.K. (1987). Vitamin B6 Deficiency Enhances End-Organ Sensitivity to Steroid Hormones. In: Korpela, T.K., Christen, P. (eds) Biochemistry of Vitamin B6 . Birkhäuser Congress Reports. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-9308-4_70
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DOI: https://doi.org/10.1007/978-3-0348-9308-4_70
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9989-5
Online ISBN: 978-3-0348-9308-4
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