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Detection of Nornicotine in Human Urine after Infusion of Nicotine

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Effects of Nicotine on Biological Systems

Part of the book series: APS Advances in Pharmacological Sciences ((APS))

Summary

The role of oxidative N-dealkylation as a pathway of the human metabolism of nicotine has been investigated after intravenous infusion of nicotine. Nornicotine has been found in the urine presenting evidence for the existence of this metabolic step. But, only less than 1% of the administered dose of nicotine is excreted as nornicotine possibly indicating rapid further metabolism.

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Author information

Authors and Affiliations

  1. Institut für Biopharmazeutische Mikroanalytik, Bötelkamp 35, D-2000, Hamburg 54, FR Germany

    G. B. Neurath, D. Orth & F. G. Pein

Authors
  1. G. B. Neurath
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  2. D. Orth
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  3. F. G. Pein
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Editor information

Editors and Affiliations

  1. Forschungsrat Rauchen und Gesundheit, Königswinterer Straße 550, D-W-5300, Bonn 3, Germany

    Franz Adlkofer M.D. (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health) (Professor of Medicine, Scientific Secretary of the Research Council on Smoking and Health)

  2. Physiologisches Institut, Universität München, Pettenkofer Straße 12, D-W-8000, München 2, Germany

    Klaus Thurau M.D. (Professor of Physiology, Chairman of the Research Council on Smoking and Health) (Professor of Physiology, Chairman of the Research Council on Smoking and Health)

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© 1991 Birkhäuser Verlag Basel

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Neurath, G.B., Orth, D., Pein, F.G. (1991). Detection of Nornicotine in Human Urine after Infusion of Nicotine. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_6

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  • DOI: https://doi.org/10.1007/978-3-0348-7457-1_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7459-5

  • Online ISBN: 978-3-0348-7457-1

  • eBook Packages: Springer Book Archive

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