Summary
Sugar uptake and cytoplasmic inducer generation appear to be regulated by the phosphenolpyruvate: sugar phosphotransferase system (PTS) by distinct mechanisms in Gram-negative versus Grampositive bacteria. In Gram-negative bacteria, the free form of the glucose-specific IIA protein of the PTS, which can be phosphorylated on a histidyl residue by PEP and the PTS energy coupling proteins, inhibits non-PTS permease activities. In Gram-positive bacteria, the phosphorylated form of the energy coupling HPr protein of the PTS, which can, be phosphorylated on a seryl residue by ATP and a protein kinase, appears to inhibit non-PTS permease activities. In this summary article, the current status of these two PTS-mediated regulatory mechanisms will be evaluated.
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© 1992 Birkhäuser Verlag, Basel/Switzerland
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Saier, M.H., Reizer, J., Deutscher, J. (1992). Protein Phosphorylation and the Regulation of Sugar Transport in Gram-Negative and Gram-Positive Bacteria. In: Papa, S., Azzi, A., Tager, J.M. (eds) Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7315-4_16
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DOI: https://doi.org/10.1007/978-3-0348-7315-4_16
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