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Increased Cell Membrane Permeability to Na+ and K+ Induced by Thyroid Hormone in Rat Skeletal Muscle

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Effectors of Thermogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 32))

Abstract

Thyroid hormone(T3) increased Na+ dependent respiration accompanied by an increase in NaK-ATPase activity. Administration of T3 increased intracellular K+ concentration and Na/K ratio in thyroidectomized rats, and the Na+ efflux rate constant incubated in oxygenized Na+, K+-Ringers in euthyroid rats. However, the magnitude of the changes in intracellular K+ concentration was modest or invisible in comparison to the changes in QO2(t) and NaK-ATPase activity. The Na and K+ efflux rate constants in K+-free +ouabain Ringers were increased by T3 in both thyroidectomized and euthyroid rats. Thus, thyroid hormone stimulates not only Na pump but also the permeability of cell membrane to Na and K. The both effects might contribute to the thyroid thermogenesis.

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References

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Author information

Authors and Affiliations

  1. Dept. of Med., Jichi Med. Sch., Kawachi, Tochigi, Japan

    Yasushi Asano

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  1. Yasushi Asano
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Editor information

Editors and Affiliations

  1. Department of Physiology, Medical School, Geneva, Switzerland

    L. Girardier  & J. Seydoux  & 

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© 1978 Springer Basel AG

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Asano, Y. (1978). Increased Cell Membrane Permeability to Na+ and K+ Induced by Thyroid Hormone in Rat Skeletal Muscle. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_22

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  • DOI: https://doi.org/10.1007/978-3-0348-5559-4_22

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5561-7

  • Online ISBN: 978-3-0348-5559-4

  • eBook Packages: Springer Book Archive

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