Abstract
Brown adipose tissue innervation as well as the effects of denervation and nerve stimulation on the metabolic activity of this tissue are briefly discussed. Direct control of the metabolic activity of brown adipocytes by sympathetic nerves was studied. Electrical stimulation was found to mimick the effects of norepinephrine on the adipocytes, i.e., it caused an increase in both NAD(P)H production and oxygen consumption of the tissue and a depolarization of the cytomembrane. These effects were graded as a function of stimulation frequency. The temporal relationship of the responses was determined and it was found that depolarization started first, was followed by pyridine nucleotide reduction and finally by an increase in respiration.
Supported by the Swiss National Foundation for Scientific Research Grant 3.522.75.
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Seydoux, J., Girardier, L. (1978). Control of Brown Fat Thermogenesis by the Sympathetic Nervous System. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_17
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DOI: https://doi.org/10.1007/978-3-0348-5559-4_17
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