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Microbiology of Bone and Joint Infections

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Histopathology of Bone and Joint Infections

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Abstract

Bone and joint infection encompasses various types of infections that can occur, in children or less often in adults, on native joints and tissues or on prosthetic material. These infections can be potentially life-, joint- or limb-threatening, even with proper recognition and treatment. Significant shifts have occurred in terms of incidence, types of infection, characteristics of high-risk patients, and microbiology, with Staphylococcus aureus remaining the most prevalent and destructive pathogen. Due to treatment challenges, having bacteriological documentation is crucial. The quality of this documentation varies depending on different factors such as infection type, sample quality, and laboratory’s expertise. The responsibility of acquiring specimens lies with the clinician, who must possess sufficient knowledge regarding appropriate sampling methods. The microbiologist can employ different techniques, including highly sensitive molecular methods. When determining the interpretation of microbiological findings, several factors need to be considered, such as underlying clinical situation, presence and types of implants, collection and processing of samples, existence or absence of other laboratory or imaging findings suggestive of infection, and prior antibiotic treatment. Considering all this, knowing basic principles is necessary for clinicians, pathologists, and microbiologists to be able to participate in a multidisciplinary discussion and decision-making around microbiological findings interpretation in each specific patient.

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References

  1. Colston J, Atkins B. Bone, and joint infection. Clin Med (Lond). 2018;18(2):150–4. https://doi.org/10.7861/clinmedicine.18-2-150.

    Article  PubMed  Google Scholar 

  2. Murillo O, Grau I, Lora-Tamayo J, Gomez-Junyent J, Ribera A, Tubau F, et al. The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century. Clin Microbiol Infect. 2015;21(3):254.e1–8. https://doi.org/10.1016/j.cmi.2014.09.007.

    Article  CAS  PubMed  Google Scholar 

  3. Letarouilly JG, Clowez A, Senneville E, Cortet B, Flipo RM. Épidémiologie et écologie des infections ostéoarticulaires bactériennes. Rev Rhum Monogr. 2022;89(2):79–83. https://doi.org/10.1016/j.monrhu.2022.01.002.

    Article  Google Scholar 

  4. Sousa R, Carvalho A, Santos AC, Abreu MA. Optimal microbiological sampling for the diagnosis of osteoarticular infection. EFORT Open Rev. 2021;6(6):390–8. https://doi.org/10.1302/2058-5241.6.210011.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dupieux C, Laurent F. Diagnostic des infections ostéo-articulaires. Rev Francoph Lab. 2016;480:47–53. https://doi.org/10.1016/S1773-035X(16)30087-9.

    Article  Google Scholar 

  6. Henry MW, Miller AO, Walsh TJ, Brause BD. Fungal musculoskeletal infections. Infect Dis Clin North Am. 2017;31(2):353–68. https://doi.org/10.1016/j.idc.2017.01.006.

    Article  PubMed  Google Scholar 

  7. García-Arias M, Balsa A, Mola EM. Septic arthritis. Best Pract Res Clin Rheumatol. 2011;25(3):407–21. https://doi.org/10.1016/j.berh.2011.02.001.

    Article  PubMed  Google Scholar 

  8. Shirtliff ME, Mader JT. Acute septic arthritis. Clin Microbiol Rev. 2002;15(4):527–44. https://doi.org/10.1128/CMR.15.4.527-544.2002.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wang DA, Tambyah PA. Septic arthritis in immunocompetent and immunosuppressed hosts. Best Pract Res Clin Rheumatol. 2015;29(2):275–89. https://doi.org/10.1016/j.berh.2015.05.008.

    Article  CAS  PubMed  Google Scholar 

  10. Yagupsky P. Native joint arthritis in children. In: Zimmerli W, editor. Bone and joint Infections from microbiology to diagnostics and treatment. Chichester: Wiley; 2015. p. 55–75.

    Chapter  Google Scholar 

  11. Ben-Chetrit E, Zamir A, Natsheh A, Nesher G, Wiener-Well Y, Breuer GS. Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: a 15-years retrospective analysis. Intern Emerg Med. 2020;15(4):655–61. https://doi.org/10.1007/s11739-019-02244-8.

    Article  PubMed  Google Scholar 

  12. Ross JJ. Septic arthritis of native joints. Infect Dis Clin North Am. 2017;31(2):203–18. https://doi.org/10.1016/j.idc.2017.01.001.

    Article  PubMed  Google Scholar 

  13. Moussiegt A, François C, Belmonte O, Jaubert J, Traversier N, Picot S, et al. Gonococcal arthritis: case series of 58 hospital cases. Clin Rheumatol. 2022;41(9):2855–62. https://doi.org/10.1007/s10067-022-06208-w.

    Article  PubMed  Google Scholar 

  14. Andersen K, Bennedbaek FN, Hansen BL. [Septic arthritis in intravenous drug abuse]. Ugeskr Laeger. 1994;156(26):3876–80.

    Google Scholar 

  15. Schmitt SK. Osteomyelitis. Infect Dis Clin North Am. 2017;31(2):325–38. https://doi.org/10.1016/j.idc.2017.01.010.

    Article  PubMed  Google Scholar 

  16. Mathew R, Hong DK. 75—Osteomyelitis. In: Long SS, editor. Principles and practice of pediatric infectious diseases. 6th ed. Philadelphia: Elsevier; 2023. p. 493–500.e3.

    Chapter  Google Scholar 

  17. Gutierrez K. Bone and joint infections in children. Pediatr Clin North Am. 2005;52(3):779–94, vi. https://doi.org/10.1016/j.pcl.2005.02.005.

    Article  PubMed  Google Scholar 

  18. Sukhtankar P, Faust SN, Clarke NMP. Osteomyelitis in children. I. In: Zimmerli W, editor. Bone and joint infections from microbiology to diagnostics and treatment. Chichester: Wiley; 2015. p. 205–20.

    Chapter  Google Scholar 

  19. Krogstad P. Osteomyelitis. In: Feigin RD, Cherry JD, Demmler-Harrison GD, Kaplan SL, editors. Textbook of pediatric infectious diseases. 6th ed. Philadelphia: Saunders Elsevier; 2009. p. 725–42.

    Chapter  Google Scholar 

  20. Uçkay I, Jugun K, Gamulin A, Wagener J, Hoffmeyer P, Lew D. Chronic osteomyelitis. Curr Infect Dis Rep. 2012;14(5):566–75. https://doi.org/10.1007/s11908-012-0286-0.

    Article  PubMed  Google Scholar 

  21. Giurato L, Meloni M, Izzo V, Uccioli L. Osteomyelitis in diabetic foot: a comprehensive overview. World J Diabetes. 2017;8(4):135–42. https://doi.org/10.4239/wjd.v8.i4.135.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Macdonald KE, Boeckh S, Stacey HJ, Jones JD. The microbiology of diabetic foot infections: a meta-analysis. BMC Infect Dis. 2021;21(1):770. https://doi.org/10.1186/s12879-021-06516-7.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Hartemann-Heurtier A, Senneville E. Diabetic foot osteomyelitis. Diabetes Metab. 2008;34(2):87–95. https://doi.org/10.1016/j.diabet.2007.09.005.

    Article  CAS  PubMed  Google Scholar 

  24. Tsantes AG, Papadopoulos DV, Vrioni G, Sioutis S, Sapkas G, Benzakour A, et al. Spinal infections: an update. Microorganisms. 2020;8(4):476. https://doi.org/10.3390/microorganisms8040476.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Uçkay I, Dinh A, Vauthey L, Asseray N, Passuti N, Rottman M, et al. Spondylodiscitis due to Propionibacterium acnes: report of twenty-nine cases and a review of the literature. Clin Microbiol Infect. 2010;16(4):353–8. https://doi.org/10.1111/j.1469-0691.2009.02801.x.

    Article  PubMed  Google Scholar 

  26. Babic M, Simpfendorfer CS. Infections of the spine. Infect Dis Clin North Am. 2017;31(2):279–97. https://doi.org/10.1016/j.idc.2017.01.003.

    Article  PubMed  Google Scholar 

  27. Drago L, De Vecchi E. Microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing. Adv Exp Med Biol. 2017;971:51–67. https://doi.org/10.1007/5584_2016_154.

    Article  PubMed  Google Scholar 

  28. Bouaziz A, Uçkay I, Lustig S, Boibieux A, Laurent F, Lew D, et al. Microbiological markers suggesting high inoculum size at time of surgery are risk factors for relapse in patients with Staphylococcus aureus prosthetic joint infection. J Infect. 2012;65(6):582–4. https://doi.org/10.1016/j.jinf.2012.09.006.

    Article  PubMed  Google Scholar 

  29. Campbell KA, Cunningham C, Hasan S, Hutzler L, Bosco JA III. Risk factors for developing Staphylococcus aureus nasal colonization in spine and arthroplasty surgery. Bull Hosp Jt Dis (2013). 2015;73(4):276–81.

    PubMed  Google Scholar 

  30. Tande AJ, Palraj BR, Osmon DR, Berbari EF, Baddour LM, Lohse CM, et al. Clinical presentation, risk factors, and outcomes of hematogenous prosthetic joint infection in patients with Staphylococcus aureus bacteremia. Am J Med. 2016;129(2):221.e11–20. https://doi.org/10.1016/j.amjmed.2015.09.006.

    Article  PubMed  Google Scholar 

  31. Tornero E, Senneville E, Euba G, Petersdorf S, Rodriguez-Pardo D, Lakatos B, et al. Characteristics of prosthetic joint infections due to Enterococcus sp. and predictors of failure: a multi-national study. Clin Microbiol Infect. 2014;20(11):1219–24. https://doi.org/10.1111/1469-0691.12721.

    Article  CAS  PubMed  Google Scholar 

  32. Everts RJ, Chambers ST, Murdoch DR, Rothwell AG, McKie J. Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints. ANZ J Surg. 2004;74(4):210–4. https://doi.org/10.1111/j.1445-2197.2004.02942.x.

    Article  PubMed  Google Scholar 

  33. Rodríguez-Pardo D, Pigrau C, Lora-Tamayo J, Soriano A, del Toro MD, Cobo J, et al. Gram-negative prosthetic joint infection: outcome of a debridement, antibiotics and implant retention approach. A large multicentre study. Clin Microbiol Infect. 2014;20(11):O911–9. https://doi.org/10.1111/1469-0691.12649.

    Article  CAS  PubMed  Google Scholar 

  34. Fernandes A, Dias M. The microbiological profiles of infected prosthetic implants with an emphasis on the organisms which form biofilms. J Clin Diagn Res. 2013;7(2):219–23. https://doi.org/10.7860/JCDR/2013/4533.2732.

    Article  PubMed  PubMed Central  Google Scholar 

  35. de Sanctis J, Teixeira L, van Duin D, Odio C, Hall G, Tomford JW, et al. Complex prosthetic joint infections due to carbapenemase-producing Klebsiella pneumoniae: a unique challenge in the era of untreatable infections. Int J Infect Dis. 2014;25:73–8. https://doi.org/10.1016/j.ijid.2014.01.028.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Gupta A, Berbari EF, Osmon DR, Virk A. Prosthetic joint infection due to Salmonella species: a case series. BMC Infect Dis. 2014;14:633. https://doi.org/10.1186/s12879-014-0633-x.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Shah NB, Tande AJ, Patel R, Berbari EF. Anaerobic prosthetic joint infection. Anaerobe. 2015;36:1–8. https://doi.org/10.1016/j.anaerobe.2015.08.003.

    Article  CAS  PubMed  Google Scholar 

  38. Fang C, Wong TM, Lau TW, To KK, Wong SS, Leung F. Infection after fracture osteosynthesis—part I: pathogenesis, diagnosis and classification. J Orthop Surg (Hong Kong). 2017;25(1):2309499017692712. https://doi.org/10.1177/2309499017692712.

    Article  PubMed  Google Scholar 

  39. Suzuki T, Morgan SJ, Smith WR, Stahel PF, Gillani SA, Hak DJ. Postoperative surgical site infection following acetabular fracture fixation. Injury. 2010;41(4):396–9. https://doi.org/10.1016/j.injury.2009.11.005.

    Article  PubMed  Google Scholar 

  40. Fenton P, Singh K, Cooper M. Clostridium difficile infection following hip fracture. J Hosp Infect. 2008;68(4):376–7. https://doi.org/10.1016/j.jhin.2008.01.021.

    Article  CAS  PubMed  Google Scholar 

  41. Hsu WK, Chou YC, Chuang CH, Li CL, Wu PT. Aeromonas hydrophilia-infected nonunion of a closed tibial fracture in a healthy adolescent: a case report. J Orthop Surg (Hong Kong). 2021;29(2):23094990211001588. https://doi.org/10.1177/23094990211001587.

    Article  Google Scholar 

  42. Kwan K, Ho ST. Mycobacterium chelonae and Mycobacterium fortuitum infection following open fracture: a case report and review of the literature. Indian J Med Microbiol. 2010;28(3):248–50. https://doi.org/10.4103/0255-0857.66488.

    Article  CAS  PubMed  Google Scholar 

  43. Themes UFO. Tuberculosis and other unusual infections. Musculoskeletal key. 2016. https://musculoskeletalkey.com/tuberculosis-and-other-unusual-infections/.

  44. Adetunji SA, Ramirez G, Foster MJ, Arenas-Gamboa AM. A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. PLoS Negl Trop Dis. 2019;13(1):e0007112. https://doi.org/10.1371/journal.pntd.0007112.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Beeching NJ, Madkour MM. Brucellosis. In: Farrar J, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, editors. Manson’s tropical infectious diseases. 23rd ed. London: W.B. Saunders; 2014. p. 371–378.e1. https://doi.org/10.1016/B978-0-7020-5101-2.00029-7.

    Chapter  Google Scholar 

  46. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352(22):2325–36. https://doi.org/10.1056/NEJMra050570.

    Article  CAS  PubMed  Google Scholar 

  47. Esmaeilnejad-Ganji SM, Esmaeilnejad-Ganji SMR. Osteoarticular manifestations of human brucellosis: a review. World J Orthop. 2019;10(2):54–62. https://doi.org/10.5312/wjo.v10.i2.54.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Taj-Aldeen SJ, Rammaert B, Gamaletsou M, Sipsas NV, Zeller V, Roilides E, et al. Osteoarticular infections caused by non-aspergillus filamentous fungi in adult and pediatric patients. Medicine (Baltimore). 2015;94(50):e2078. https://doi.org/10.1097/MD.0000000000002078.

    Article  CAS  PubMed  Google Scholar 

  49. Mack D, Warren S, Palanivel S, Conlon CP. Fungal bone and joint infections. In: Kibbler CC, Barton R, Gow NAR, Howell S, MacCallum DM, Manuel RJ, et al., editors. Oxford textbook of medical mycology. 2018 online ed. Oxford: Oxford Academic; 2017. https://doi.org/10.1093/med/9780198755388.003.0020.

  50. Drago L, Clerici P, Morelli I, Ashok J, Benzakour T, Bozhkova S, et al. The World Association against Infection in Orthopaedics and Trauma (WAIOT) procedures for microbiological sampling and processing for Periprosthetic Joint Infections (PJIs) and other implant-related infections. J Clin Med. 2019;8(7):933. https://doi.org/10.3390/jcm8070933.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Couderc M, Bart G, Coiffier G, Godot S, Seror R, Ziza JM, et al. Recommandations françaises 2020 sur la prise en charge des arthrites septiques sur articulation native de l’adulte. Rev Rhum. 2020;87(6):428–38. https://doi.org/10.1016/j.rhum.2020.05.004.

    Article  Google Scholar 

  52. Sigmund IK, McNally MA. Diagnosis of bone and joint infections. Orthop Trauma. 2019;33(3):144–52. https://doi.org/10.1016/j.mporth.2019.03.001.

    Article  Google Scholar 

  53. Dubost JJ, Soubrier M, Sauvezie B. Arthrite septique à pyogène de l’adulte. Rev Rhum. 2000;67(1):17–27.

    Article  Google Scholar 

  54. La Société de Pathologie Infectieuse de Langue Française (SPILF), Collège des Universitaires de Maladies Infectieuses et Tropicales (CMIT), Groupe de Pathologie Infectieuse Pédiatrique (GPIP), Société Française d’Anesthésie et de Réanimation (SFAR), Société Française de Chirurgie Orthopédique et Traumatologique (SOFCOT), Société Française d’Hygiène Hospitalière (SFHH), et al.Recommandations de pratique clinique. Infections ostéo-articulaires sur matériel (prothèse, implant, ostéo-synthèse). Med Mal Infect. 2009;39(11):815–63. https://doi.org/10.1016/j.medmal.2009.05.004.

    Article  Google Scholar 

  55. Spellberg B, Aggrey G, Brennan MB, Footer B, Forrest G, Hamilton F, et al. Use of novel strategies to develop guidelines for management of pyogenic osteomyelitis in adults: a WikiGuidelines Group Consensus Statement. JAMA Netw Open. 2022;5(5):e2211321. https://doi.org/10.1001/jamanetworkopen.2022.11321.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Woods CR, Bradley JS, Chatterjee A, Copley LA, Robinson J, Kronman MP, et al. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Pediatr Infect Dis Soc. 2021;10(8):801–44. https://doi.org/10.1093/jpids/piab027.

    Article  Google Scholar 

  57. Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, et al. 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis. 2015;61(6):e26–46. https://doi.org/10.1093/cid/civ482.

    Article  PubMed  Google Scholar 

  58. Lacasse M, Derolez S, Bonnet E, Amelot A, Bouyer B, Carlier R, et al. Review group. 2022 SPILF—Clinical Practice guidelines for the diagnosis and treatment of disco-vertebral infection in adults. Infect Dis Now. 2023;53(3):104647. https://doi.org/10.1016/j.idnow.2023.01.007.

    Article  CAS  PubMed  Google Scholar 

  59. Schechter MC, Ali MK, Risk BB, Singer AD, Santamarina G, Rogers HK, et al. Percutaneous bone biopsy for diabetic foot osteomyelitis: a systematic review and meta-analysis. Open Forum Infect Dis. 2020;7(10):ofaa393. https://doi.org/10.1093/ofid/ofaa393.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Kosmopoulou OA, Dumont IJ. Feasibility of percutaneous bone biopsy as part of the management of diabetic foot osteomyelitis in a 100% neuropathic, grade 3 IDSA/IWGDF population on an outpatient basis. Int J Low Extrem Wounds. 2020;19(4):382–7. https://doi.org/10.1177/1534734620902609.

    Article  PubMed  Google Scholar 

  61. Chometon S, Benito Y, Chaker M, Boisset S, Ploton C, Bérard J, et al. Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children. Pediatr Infect Dis J. 2007;26(5):377–81. https://doi.org/10.1097/01.inf.0000259954.88139.f4.

    Article  PubMed  Google Scholar 

  62. Esteban J, Gómez-Barrena E. An update about molecular biology techniques to detect orthopaedic implant-related infections. EFORT Open Rev. 2021;6(2):93–100. https://doi.org/10.1302/2058-5241.6.200118.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Coiffier G, Bart G. Tuberculosis vertebral del adulto. EMC—Aparato Locomotor. 2020;53(4):1–18.

    Article  Google Scholar 

  64. Agashe VM, Johari AN, Shah M, Anjum R, Romano C, Drago L, et al. Diagnosis of osteoarticular tuberculosis: perceptions, protocols, practices, and priorities in the endemic and non-endemic areas of the world—a WAIOT view. Microorganisms. 2020;8(9):1312. https://doi.org/10.3390/microorganisms8091312.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Dorman SE, Schumacher SG, Alland D, Nabeta P, Armstrong DT, King B, et al. Xpert MTB/RIF ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis. 2018;18(1):76–84. https://doi.org/10.1016/S1473-3099(17)30691-6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Menichini M, Lari N, Lupetti A, Rindi L. Evaluation of Xpert MTB/RIF Ultra assay for rapid diagnosis of pulmonary and extra-pulmonary tuberculosis in an Italian center. Eur J Clin Microbiol Infect Dis. 2020;39(8):1597–600. https://doi.org/10.1111/j.1574-695X.2012.00972.x.

    Article  CAS  PubMed  Google Scholar 

  67. Fan L, Chen Z, Hao XH, Hu ZY, Xiao HP. Interferon-gamma release assays for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis. FEMS Immunol Med Microbiol. 2012;65(3):456–66.

    Article  CAS  PubMed  Google Scholar 

  68. Rangaka MX, Wilkinson KA, Glynn JR, Ling D, Menzies D, Mwansa-Kambafwile J, et al. Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(1):45–55. https://doi.org/10.1016/S1473-3099(11)70210-9.

    Article  CAS  PubMed  Google Scholar 

  69. Yagupsky P, Morata P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev. 2019;33(1):e00073–19. https://doi.org/10.1128/CMR.00073-19.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Chelli Bouaziz M, Ladeb MF, Riahi H, Achour W, Berriche A, Ammari L, et al. Imaging of spinal brucellosis. In: Ladeb MF, Peh WCG, editors. Imaging of spinal infection. Cham: Springer International Publishing; 2021. p. 183–97. https://doi.org/10.1007/978-3-030-70459-9_10.

    Chapter  Google Scholar 

  71. Nace J, Siddiqi A, Talmo CT, Chen AF. Diagnosis and management of fungal periprosthetic joint infections. J Am Acad Orthop Surg. 2019;27(18):e804–18. https://doi.org/10.5435/JAAOS-D-18-00331.

    Article  PubMed  Google Scholar 

  72. Sambri A, Zunarelli R, Fiore M, Bortoli M, Paolucci A, Filippini M, et al. Epidemiology of fungal periprosthetic joint infection: a systematic review of the literature. Microorganisms. 2023;11(1):84. https://doi.org/10.3390/microorganisms11010084.

    Article  CAS  Google Scholar 

  73. Bariteau JT, Waryasz GR, McDonnell M, Fischer SA, Hayda RA, Born CT. Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg. 2014;22(6):390–401. https://doi.org/10.5435/JAAOS-22-06-390.

    Article  PubMed  Google Scholar 

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Acknowledgments

Thank you to Dr. Basma Mnif for providing the photos.

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Authors and Affiliations

  1. Laboratory Ward, National Bone Marrow Transplant Center—Research Laboratory LR18ES39, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia

    Yosra Chebbi, Siwar Frigui & Wafa Achour

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  1. Yosra Chebbi
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  2. Siwar Frigui
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Correspondence to Wafa Achour .

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  1. Department of Pathology, Charles-Nicolle Hospital, Tunis, Tunisia

    Soumaya Rammeh Rommani

  2. Department of Radiology, Mohamed Kassab Institute of Orthopedics, Ksar Said, Tunisia

    Mohamed Fethi Ladeb

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Chebbi, Y., Frigui, S., Achour, W. (2024). Microbiology of Bone and Joint Infections. In: Rammeh Rommani, S., Ladeb, M.F. (eds) Histopathology of Bone and Joint Infections. Springer, Cham. https://doi.org/10.1007/978-3-031-54888-8_2

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