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Cat-Scratch Disease in Children and Hearing Loss

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Hearing Loss in Congenital, Neonatal and Childhood Infections

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Abstract

Cat-scratch disease (CSD), a zoonotic disease worldwide, causes significant acute and chronic health problems. Several clinical manifestations of CSD have been reported in humans for more than a century. Until 1993, human diseases caused by Bartonella species have not been well-described [1]. Bartonella spp. were first recognized as a causative agent of endocarditis. With the advances in serological and molecular tests, expansion of up to 30 Bartonella spp. has been detected [2]. Bartonella bacilliformis, Bartonella henselae, and Bartonella quintana are the most common species causing human disease. Bartonella henselae, the causative agent of CSD, is the most common species of Bartonella-associated infection in children. Bartonella clarridgeiae has also been reported in some cases [3].

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References

  1. Anderson BE, Neuman MA. Bartonella spp. as emerging human pathogens. Clin Microbiol Rev. 1997;10:203–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Biswas S, Rolain JM. Bartonella infection: treatment and drug resistance. Future Microbiol. 2010;5:1719–31.

    Article  CAS  PubMed  Google Scholar 

  3. Kordick DL, Hilyard EJ, Hadfield TL, et al. Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease). J Clin Microbiol. 1997;35:1813–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Alsmark CM, Frank AC, Karlberg EO, et al. The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae. Proc Natl Acad Sci U S A. 2004;101:9716–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Howard LM, Edwards KM. Bartonella infections. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry's textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 1240–6.

    Google Scholar 

  6. Zangwill KM. Cat scratch disease and other Bartonella infections. Adv Exp Med Biol. 2013;764:159–66.

    Article  CAS  PubMed  Google Scholar 

  7. Jameson P, Greene C, Regnery R, et al. Prevalence of Bartonella henselae antibodies in pet cats throughout regions of North America. J Infect Dis. 1995;172:1145–9.

    Article  CAS  PubMed  Google Scholar 

  8. Kwon HY, Im JH, Lee SM, et al. The seroprevalence of Bartonella henselae in healthy adults in Korea. Korean J Intern Med. 2017;32:530–5.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Zangwill KM, Hamilton DH, Perkins BA, et al. Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test. N Engl J Med. 1993;329:8–13.

    Article  CAS  PubMed  Google Scholar 

  10. Alonso BR, Alonso-Sardón M, Almeida HMR, et al. Epidemiological of cat scratch disease among inpatients in the Spanish health system (1997–2015). Eur J Clin Microbiol Infect Dis. 2021;40:849–57.

    Article  Google Scholar 

  11. Nelson CA, Saha S, Mead PS. Cat-scratch disease in the United States, 2005–2013. Emerg Infect Dis. 2016;22:1741–6.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Noah DL, Kramer CM, Verbsky MP, et al. Survey of veterinary professionals and other veterinary conference attendees for antibodies to Bartonella henselae and B. quintana. J Am Vet Med Assoc. 1997;210:342–4.

    CAS  PubMed  Google Scholar 

  13. Scolfaro C, Mignone F, Genarri F, et al. Possible donor-recipient bartonellosis transmission in a pediatric liver transplant. Transpl Infect Dis. 2008;10:431–3.

    Article  CAS  PubMed  Google Scholar 

  14. Okaro U, Addisu A, Casanas B, Anderson B. Bartonella species, an emerging cause of blood-culture-negative endocarditis. Clin Microbiol Rev. 2017;30:709–46.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Eicher SC, Dehio C. Bartonella entry mechanisms into mammalian host cells. Cell Microbiol. 2012;14:1166–73.

    Article  CAS  PubMed  Google Scholar 

  16. Balakrishnan N, Cherry NA, Linder KE, et al. Experimental infection of dogs with Bartonella henselae and Bartonella vinsonii subsp. berkhoffii. Vet Immunol Immunopathol. 2013;156:153–8.

    Article  PubMed  Google Scholar 

  17. Nelson CA, Moore AR, Perea AE, Mead PS. Cat scratch disease: U.S. clinicians' experience and knowledge. Zoonoses Public Health. 2018;65:67–73.

    Article  CAS  PubMed  Google Scholar 

  18. Han JY, Vijayan V. Bartonella species (cat-scratch disease). In: Long SS, Prober CG, Fischer M, Kimberlin DW, editors. Principles and practice of pediatric infectious diseases. 6th ed. Philadelphia: Elsevier; 2023. p. 901–5.

    Chapter  Google Scholar 

  19. Nakamura C, Inaba Y, Tsukahara K, et al. A pediatric case with peripheral facial nerve palsy caused by a granulomatous lesion associated with cat scratch disease. Brain Dev. 2018;40:159–62.

    Article  PubMed  Google Scholar 

  20. Mazur-Melewska K, Mania A, Kemnitz P, Figlerowicz M, Służewski W. Cat-scratch disease: a wide spectrum of clinical pictures. Postepy Dermatol Alergol. 2015;32:216–20.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Chang CC, Lee CJ, Ou LS, Wang CJ, Huang YC. Disseminated cat-scratch disease: case report and review of the literature. Paediatr Int Child Health. 2016;36:232–4.

    Article  PubMed  Google Scholar 

  22. Del Pozo AA, Angulo-Cruzado M, Amenero-Vega R, et al. Hepatosplenic abscesses in an immunocompetent child with cat-scratch disease from Peru. Ann Clin Microbiol Antimicrob. 2019;18:23.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Arisoy ES, Correa AG, Wagner ML, Kaplan SL. Hepatosplenic cat-scratch disease in children: selected clinical features and treatment. Clin Infect Dis. 1999;28:778–84.

    Article  CAS  PubMed  Google Scholar 

  24. Zouari S, Khrouf F, M’Ghirbi Y, Bouattour A. First molecular detection and characterization of zoonotic Bartonella species in fleas infesting domestic animals in Tunisia. Parasit Vectors. 2017;10(1):436.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Sodini C, Zani EM, Pecora F, et al. A case of atypical bartonellosis in a 4-year-old immunocompetent child. Microorganisms. 2021;9:950.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Jacobs RF, Schutze GE. Bartonella henselae as a cause of prolonged fever and fever of unknown origin in children. Clin Infect Dis. 1998;26:80–4.

    Article  CAS  PubMed  Google Scholar 

  27. Florin TA, Zaoutis TE, Zaoutis LB. Beyond cat scratch disease: widening spectrum of Bartonella henselae infection. Pediatrics. 2008;121:1413–25.

    Article  Google Scholar 

  28. Fournier P, Franck T, Richet H, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010;51:131–40.

    Article  CAS  PubMed  Google Scholar 

  29. Nawrocki CC, Max RJ, Marzec NS, et al. Atypical manifestations of cat-scratch disease, United States, 2005-2014. Emerg Infect Dis. 2020;26:1438–46.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Reynolds MG, Holman RC, Curns AT, et al. Epidemiology of cat-scratch disease hospitalizations among children in the United States. Pediatr Infect Dis J. 2005;24:700–4.

    Article  PubMed  Google Scholar 

  31. Carithers HA, Margileth AM. Cat-scratch disease. Acute encephalopathy and other neurologic manifestations. Am J Dis Child. 1991;145:98–101.

    Article  CAS  PubMed  Google Scholar 

  32. Johnson A. Ocular complications of cat scratch disease. Br J Ophthalmol. 2020;104:1640–6.

    Article  PubMed  Google Scholar 

  33. Dixon MK, Dayton CL, Anstead GM. Parinaud's oculoglandular syndrome: a case in an adult with flea-borne typhus and a review. Trop Med Infect Dis. 2020;5:126.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Domínguez I, Cartes C, Sabat P, Ortiz O, Matus G, Traipe L. Isolated conjunctival granuloma as a first manifestation of Parinaud's oculoglandular syndrome: a case report. Am J Ophthalmol Case Rep. 2019;14:58–60.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Seth A, Raina UK, Thirumalai S, Batta S, Ghosh B. Full-thickness macular hole in Bartonella henselae neuroretinitis in an 11-year-old girl. Oman J Ophthalmol. 2015;8:44–6.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Ahmadi S, Azizi B, Tsang AC, Coupland S, Gottlieb C, Zackon D. Neuroretinitis with branch retinal artery occlusion in a 15-year-old female. Case Rep Ophthalmol. 2013;4:265–8.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Schattner A, Uliel L, Dubin I. The cat did it: erythema nodosum and additional atypical presentations of Bartonella henselae infection in immunocompetent hosts. BMJ Case Rep. 2018;2018:bcr2017222511.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zellali K, Benard E, Smokvina E, Belgaid A, Labbé F, Bertrand V. Multifocal pelvic osteomyelitis in a child associated with cat-scratch disease: a case report and review of the literature. Paediatr Int Child Health. 2019;39:290–3.

    Article  CAS  PubMed  Google Scholar 

  39. Maman E, Bickels J, Ephros M, et al. Musculoskeletal manifestations of cat-scratch disease. Clin Infect Dis. 2007;45:1535–40.

    Article  PubMed  Google Scholar 

  40. Lins KA, Drummond MR, Velho PE. Cutaneous manifestations of bartonellosis. An Bras Dermatol. 2019;94:594–602.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Le Joncour A, Bidegain F, Ziol M, et al. Hemophagocytic lymphohistiocytosis associated with Bartonella henselae infection in an HIV-infected patient. Clin Infect Dis. 2016;62:804–6.

    Article  PubMed  Google Scholar 

  42. Yang T, Mei Q, Zhang L, et al. Hemophagocytic lymphohistiocytosis is associated with Bartonella henselae infection in a patient with multiple susceptibility genes. Ann Clin Microbiol Antimicrob. 2020;19(1):28.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Poudel A, Lew J, Slayton W, Dharnidharka VR. Bartonella henselae infection inducing hemophagocytic lymphohistiocytosis in a kidney transplant recipient. Pediatr Transplant. 2014;18:e83–7.

    Article  PubMed  Google Scholar 

  44. Spach DH, Kaplan SL. Treatment of cat-scratch disease. In: Calderwood SB, Edwards MS, editors. UpToDate. Waltham, MA: UpToDate; 2022. Updated: Dec 09, 2021; literature review. https://www.uptodate.com/contents/treatment-of-cat-scratch-disease. Accessed 3Nov 2022.

    Google Scholar 

  45. Rose SR, Koehler JE. Bartonella, including cat-scratch disease. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett's principles and practice of infectious diseases. 9th ed. Philadelphia: Elsevier; 2020. p. 2824–43.

    Google Scholar 

  46. Silver BE, Bean CS. Cat scratch encephalopathy. Del Med J. 1991;63:365–8.

    CAS  PubMed  Google Scholar 

  47. Yagupsky P, Sofer S. Cat-scratch encephalopathy presenting as status epilepticus and lymphadenitis. Pediatr Emerg Care. 1990;6:43–5.

    Article  CAS  PubMed  Google Scholar 

  48. Whitman BW, Krafte-Jacobs B. Cat-scratch disease associated with pleural effusions and encephalopathy in a child. Respiration. 1995;62:171–3.

    Article  CAS  PubMed  Google Scholar 

  49. Canneti B, Cabo-López I, Puy-Núñez A, et al. Neurological presentations of Bartonella henselae infection. Neurol Sci. 2019;40:261–8.

    Article  CAS  PubMed  Google Scholar 

  50. Jacomo V, Kelly PJ, Raoult D. Natural history of Bartonella infections (an exception to Koch's postulate). Clin Diagn Lab Immunol. 2002;9:8–18.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Pischel L, Radcliffe C, Vilchez GA, Charifa A, Zhang XC, Grant M. Bartonellosis in transplant recipients: a retrospective single-center experience. World J Transplant. 2021;11:244–53.

    Article  PubMed  PubMed Central  Google Scholar 

  52. American Academy of Pediatrics. Antimicrobial therapy according to clinical syndromes. In: Bradley JS, Nelson JD, Barnett ED, et al., editors. 2022 Nelson's pediatric antimicrobial therapy. 28th ed. Itasca, IL: American Academy of Pediatrics; 2022. p. 65.

    Google Scholar 

  53. Purvin V, Sundaram S, Kawasaki A. Neuroretinitis: review of the literature and new observations. J Neuroophthalmol. 2011;31:58–68.

    Article  PubMed  Google Scholar 

  54. Raihan AR, Zunaina E, Wan-Hazabbah WH, Adil H, Lakana-Kumar T. Neuroretinitis in ocular bartonellosis: a case series. Clin Ophthalmol. 2014;8:1459–66.

    PubMed  PubMed Central  Google Scholar 

  55. Habot-Wilner Z, Trivizki O, Goldstein M, et al. Cat-scratch disease: ocular manifestations and treatment outcome. Acta Ophthalmol. 2018;96:524–32.

    Article  Google Scholar 

  56. Fan J, Ali H. Cat scratch disease causing encephalitis. Proc (Baylor Univ Med Cent). 2020;33:440–1.

    Article  Google Scholar 

  57. Clinicalinfo. Bartonellosis. In: Panel on opportunistic infections in HIV-infected adults and adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America (updated: Jun 11, 2021; reviewed: Jul 13, 2022). 2022:C1–C8. https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/adult-adolescent-oi/bartonellosis-adult-adolescent-oi.pdf. Accessed 3 Nov 2022.

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Kara, S.S., Arısoy, E.S., Correa, A.G. (2023). Cat-Scratch Disease in Children and Hearing Loss. In: Arısoy, A.E., Arısoy, E.S., Bayar Muluk, N., Cingi, C., Correa, A.G. (eds) Hearing Loss in Congenital, Neonatal and Childhood Infections. Comprehensive ENT. Springer, Cham. https://doi.org/10.1007/978-3-031-38495-0_39

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  • DOI: https://doi.org/10.1007/978-3-031-38495-0_39

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