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Engineering Dynamic 3D Models of Lung

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Engineering Translational Models of Lung Homeostasis and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1413))

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Abstract

The lung parenchyma—consisting of gas-filled alveoli, vasculature, and connective tissue—is the site for gas exchange in the lung and plays a critical role in a number of chronic lung diseases. In vitro models of lung parenchyma can, therefore, provide valuable platforms for the study of lung biology in health and disease. Yet modeling such a complex tissue requires integrating multiple components, including biochemical cues from the extracellular environment, geometrically defined multicellular interactions, and dynamic mechanical inputs such as the cyclic stretch of breathing. In this chapter, we provide an overview of the broad spectrum of model systems that have been developed to recapitulate one or more features of lung parenchyma, and some of the scientific advances generated by those models. We discuss the use of both synthetic and naturally derived hydrogel materials, precision-cut lung slices, organoids, and lung-on-a-chip devices, with perspectives on the strengths, weaknesses, and potential future directions of these engineered systems.

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    Rachel Blomberg, Rukshika S. Hewawasam, Predrag Šerbedžija, Kamiel Saleh, Thomas Caracena & Chelsea M. Magin

  2. Department of Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

    Chelsea M. Magin

  3. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

    Chelsea M. Magin

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Blomberg, R., Hewawasam, R.S., Šerbedžija, P., Saleh, K., Caracena, T., Magin, C.M. (2023). Engineering Dynamic 3D Models of Lung. In: Magin, C.M. (eds) Engineering Translational Models of Lung Homeostasis and Disease. Advances in Experimental Medicine and Biology, vol 1413. Springer, Cham. https://doi.org/10.1007/978-3-031-26625-6_9

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