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Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications pp 29–52Cite as

Biology of Ceramic Bone Substitutes

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Part of the book series: Engineering Materials ((ENG.MAT.))

Abstract

The human skeleton has the miraculous capacity of healing itself when needed through a cascade known as bone remodeling. However, bone tissue is not able to regenerate itself in case of a broad variety of defects. In these cases, bone substitution is necessary to enable and support the process of bone remodeling. The gold standard for the regeneration of critical-sized bone defects is the transplantation of patient's own bone tissue harvested from another body region. This harvested bone tissue is called an autograft. Due to its donor site morbidity and limited availability, the use of bone tissue harvested from another individual (allografts) or from another species (xenograft) or synthetic materials that are chemically and structurally mimicking to native bone tissue (alloplastic grafts) has been established. This book chapter covers the physiological phenomenon of bone tissue remodeling and the different bone substitute materials (BSMs). The chapter also sheds a light on tissue responses to biomaterials, as well as inflammation in physiological bone tissue healing and inflammation induced by implanted BSMs. Inflammation generally has a negative connotation, but this chapter intends to elaborate on inflammation as an inherent and important process in bone tissue healing.

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Authors and Affiliations

  1. BerlinAnalytix GmbH, Ullsteinstrasse 108, 12109, Berlin, Germany

    Mike Barbeck & Said Alkildani

  2. Clinic and Policlinic for Dermatology and Venereology, Rostock University Medical Center, Strempelstraße 13, 18057, Rostock, Germany

    Mike Barbeck, Said Alkildani & Ole Jung

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  1. Faculty of Medicine, University of Niš, Niš, Serbia

    Stevo Najman

  2. (Deceased), Niš, Serbia

    Vojislav Mitić

  3. Department of Biomedical Materials, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

    Thomas Groth

  4. BerlinAnalytix GmbH, Berlin, Germany

    Mike Barbeck

  5. Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

    Po-Yu Chen

  6. School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD, Australia

    Ziqi Sun

  7. Department of Mathematics, Faculty of Electronic Engineering, University of Niš, Niš, Serbia

    Branislav Randjelović

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Barbeck, M., Alkildani, S., Jung, O. (2023). Biology of Ceramic Bone Substitutes. In: Najman, S., et al. Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-031-17269-4_2

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