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Abdominal Pain-Related Functional Gastrointestinal Disorder and Disorders of Brain–Gut Interactions

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Pediatric Neurogastroenterology

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Abstract

Chronic abdominal pain accounts for approximately 50% of referrals to pediatric gastroenterologists, with most children suffering from functional abdominal pain (FAP) disorders (FAPDs). FAPDs include functional dyspepsia, irritable bowel syndrome, abdominal migraine, and FAP–not otherwise specified. Etiologies include genetic predisposition and events that lead to disruption of the brain–gut–microbiota axis, such as environmental and psychosocial stressors, disruption of the gut microbiota, and early life events that lead to hyperalgesia, such as cow’s milk protein. FAPDs lead to impaired quality of life and increased health care costs. Unfortunately, treatment options are limited given most are studied in adults and not children, thus making FAPDs difficult to manage in pediatrics.

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  1. Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Miami, Miami, FL, USA

    Liz Febo-Rodriguez & Miguel Saps

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  1. Liz Febo-Rodriguez
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  1. Division of Gastroenterology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada

    Christophe Faure

  2. Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital School of Medicine University of Queensland, Brisbane, QLD, Australia

    Nikhil Thapar

  3. Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, Columbus, OH, USA

    Carlo Di Lorenzo

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Febo-Rodriguez, L., Saps, M. (2022). Abdominal Pain-Related Functional Gastrointestinal Disorder and Disorders of Brain–Gut Interactions. In: Faure, C., Thapar, N., Di Lorenzo, C. (eds) Pediatric Neurogastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-031-15229-0_37

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