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Gerobiotics: Probiotics for Healthy Aging

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Book cover Gut Microbiota in Aging and Chronic Diseases

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 17))

Abstract

Aging, despite its ubiquity, and its underlying mechanisms are still not well understood. A collection of biological processes known as hallmarks of aging offer to explain this unavoidable phenomenon, while the interdisciplinary field of geroscience strives to define its physiological mechanisms at both a molecular and cellular level. Geroscience hypothesizes that comprehensively targeting these hallmarks can prevent aging-related pathogenesis, therefore, improving the healthspan of most people. There is also growing awareness that probiotics can be used prophylactically to maintain health and improve life quality among the elderly. Rapidly advancing geroscience research includes a focus on anti-aging probiotics. If extensive preclinical and clinical research confirms a particular probiotic’s efficacy to truly attenuate the fundamental mechanisms of aging, reduce physiological aging processes, and thereby extend the healthspan of the host, then this strain along with its derived postbiotics and para-probiotics could be designated as “gerobiotics”. This chapter highlights the significance of the novel field of gerobiotics, epitomizing biomarkers of aging and recommending a path by which to discover gerobiotic strains and develop their ensuing products. Finally, we will provide several examples of potential gerobiotics. By exploiting these unique strains, we could formulate interventional strategies that slow or even reverse expressions of aging, improving healthspan and longevity for future generations.

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Authors and Affiliations

  1. Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan

    Ying-Chieh Tsai

  2. Institute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan

    Sabrina Wang

  3. Bened Biomedical Co., Ltd., Taipei, 10448, Taiwan

    Li-Hao Cheng & One-Jang Jeng

  4. ReGenera R&D International for Aging Intervention and Longevity & Vitality in Medical Science Commission, FEMTEC World Federation, Milan, Italy

    Francesco Marotta

Authors
  1. Ying-Chieh Tsai
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  2. Sabrina Wang
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  3. Li-Hao Cheng
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  4. One-Jang Jeng
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  5. Francesco Marotta
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Correspondence to Ying-Chieh Tsai .

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  1. ReGenera R&D International for Aging Intervention, Milan, Italy

    Francesco Marotta

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Tsai, YC., Wang, S., Cheng, LH., Jeng, OJ., Marotta, F. (2023). Gerobiotics: Probiotics for Healthy Aging. In: Marotta, F. (eds) Gut Microbiota in Aging and Chronic Diseases. Healthy Ageing and Longevity, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-031-14023-5_16

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