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The Systemic Effects of Advanced Cancer pp 9–39Cite as

Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles

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Abstract

Cancer is a systemic disease that induces functional dysregulation in multiple tissues and organs. The great majority of cancer-related deaths are due to metastasis, a multistep process involving crosstalk between cancer cells and stromal cells and immune cells in pre-metastatic niches (PMNs) at distant organs. As message carriers, extracellular vesicles and particles (EVPs) derived from cancer cells can modulate the phenotype of recipient cells by transferring various biomolecules, including nucleic acids, proteins, metabolites and lipids, thereby contributing to PMN formation and metastasis. In this chapter, we highlight the roles of cancer cell-derived EVPs in metastasis progression, with a focus on PMN establishment.

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Acknowledgments

The authors gratefully acknowledge support from the following funding sources: the National Cancer Institute CA224175 (to D.L.), CA210240 (to D.L.), CA232093 (to D.L.), CA163117 (to D.L.), CA207983 (to D.L.), CA163120 (to D.L.), CA169416 (to D.L.), CA169538 (to D.L.), CA218513 (to D.L. and H.Z.) and AI144301 (to D.L.), the United States Department of Defense (W81XWH-13-1-0425, W81XWH-13-1-0427, W81XWH-13-1-0249 and W81XWH-14-1-0199 (to D.L.)), the Malcolm Hewitt Weiner Foundation (to D.L.), the Hartwell Foundation (to D.L.), the Manning Foundation (to D.L.), the Thompson Family Foundation (to D.L.), The Daniel P. and Nancy C. Paduano Family Foundation (to D.L.), the James Paduano Foundation (to D.L.), the Sohn Foundation (to D.L.), the STARR Consortium I9-A9-056 (to D.L. and H.Z.), the STARR Consortium I8-A8-123 (to D.L.), the AHEPA Vth District Cancer Research Foundation (to D.L.), the Pediatric Oncology Experimental Therapeutics Investigator’s Consortium (to D.L.), the Alex’s Lemonade Stand Foundation (to D.L.), the Breast Cancer Research Foundation (to D.L.), the Daedalus Fund (Weill Cornell Medicine, to D.L.), the Feldstein Medical Foundation (to D.L.), the Tortolani Foundation (to D.L.), the Children’s Cancer and Blood Foundation (to D.L.), the Clinical & Translational Science Center (to D.L. and H.Z.), the Mary K. Ash Charitable Foundation (to D.L.), the Selma and Lawrence Ruben Science to Industry Bridge Fund (to D.L.). Figures were created using the templates from Servier Medical Art, licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com.

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  1. Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

    Gang Wang, Candia M. Kenific, Grace Lieberman, Haiying Zhang & David Lyden

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  1. Columbia University Irving Medical Center, New York, NY, USA

    Swarnali Acharyya

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Wang, G., Kenific, C.M., Lieberman, G., Zhang, H., Lyden, D. (2022). Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles. In: Acharyya, S. (eds) The Systemic Effects of Advanced Cancer. Springer, Cham. https://doi.org/10.1007/978-3-031-09518-4_2

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