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PI3K Isoforms in B Cells

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PI3K and AKT Isoforms in Immunity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 436))

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Abstract

Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology. Three different classes of PI3K have been described, all of which are expressed in B cells. However, it is the class IA PI3Ks, and the p110δ catalytic subunit in particular, which seem to play the most critical role in B cells. Here we discuss the important role that class IA PI3K plays in B cell development, activation and differentiation, as well as examine what is known about the other classes of PI3Ks in B cells.

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Abbreviations

AID:

Activation-induced cytidine deaminase protein

BCR:

B cell receptor

DZ:

Dark zone

FOXO:

Forkhead box O

GCs:

Germinal centres

GOF:

Gain of function

Ig:

Immunoglobulin

LOF:

Loss of function

LZ:

Light zone

mTORC1:

Mechanistic target of rapamycin complex 1

mTORC2:

Mechanistic target of rapamycin complex 2

MZ:

Marginal Zone

PDK1:

Phosphoinositide-dependent kinase-1

PI3K:

Phosphatidylinositol-3-kinase

PI-(4,5)-P2:

Phosphatidylinositol-(4,5)-biphosphate

PIP3:

Phosphatidylinositol-(3,4,5)-trisphosphate

PTEN:

Phosphatase and tensin homolog deleted on chromosome ten

RAG1:

Recombination-activating genes 1

RAG2:

Recombination-activating genes 2

SHIP:

SH2-domain containing inositol-5-phosphatases

TD:

T dependent

TI:

T independent

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Authors and Affiliations

  1. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    Elissa K. Deenick, Julia Bier & Anthony Lau

  2. Faculty of Medicine and Health, UNSW, Sydney, Australia

    Elissa K. Deenick

  3. St Vincent’s Clinical School, Faculty of Medicine and Health, UNSW, Sydney, Australia

    Julia Bier & Anthony Lau

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  1. Elissa K. Deenick
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  2. Julia Bier
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  3. Anthony Lau
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Correspondence to Elissa K. Deenick .

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  1. Faculty of Medicine, Imperial College London, London, UK

    Margarita Dominguez-Villar

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Deenick, E.K., Bier, J., Lau, A. (2022). PI3K Isoforms in B Cells. In: Dominguez-Villar, M. (eds) PI3K and AKT Isoforms in Immunity . Current Topics in Microbiology and Immunology, vol 436. Springer, Cham. https://doi.org/10.1007/978-3-031-06566-8_10

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