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Toxoplasmosis in South America

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Infectious Tropical Diseases and One Health in Latin America

Part of the book series: Parasitology Research Monographs ((Parasitology Res. Monogr.,volume 16))

Abstract

The protozoan parasite Toxoplasma gondii is distributed worldwide and parasitizes animals as well as humans. The latter become infected by eating raw or undercooked meat of infected animals (e.g., that of pigs). Infections of pregnant women may lead to infections of the fetus introducing eventually very severe symptoms of disease or even death of the growing fetus. Thus, doctors should inform pregnant women to avoid raw meat.

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References and Further Reading

  • Adomako-Ankomah Y, Wier GM, Boyle JP (2012) Beyond the genome: recent advances in Toxoplasma gondii functional genomics. Parasite Immunol 34(2–3):80–89

    Article  CAS  PubMed  Google Scholar 

  • Aguirre AA, Longcore T, Barbieri M, Dabritz H, Hill D, Klein PN, Lepczyk C, Lilly EL, McLeod R, Milcarsky J, Murphy CE, Su C, Van Wormer E, Yolken R, Sizemore GC (2019) The one health approach to toxoplasmosis: epidemiology, control and prevention strategies. EcoHealth 16:378–390

    Article  PubMed  PubMed Central  Google Scholar 

  • Ajzenberg D, Bañuls AL, Su C et al (2004) Genetic diversity, clonality and sexuality in Toxoplasma gondii. Int J Parasitol 34:1185–1196

    Article  CAS  PubMed  Google Scholar 

  • Alban L, Häsler B, van Schaik G, Ruegg S (2020) Risk-based surveillance for meat-borne parasites. Exp Parasitol 208:107808

    Article  PubMed  Google Scholar 

  • Alday PH, Doggett JS (2017) Drugs in development for toxoplasmosis: advances, challenges, and current status. Drug Des Devel Ther 11:273–293

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alvarado-Esquivel C, Sifuentes-Alvarez A, Narro-Duarte SG, Estrada-Martinez S, Diaz-Garcia JH, Liesenfeld O, Martinez-Garcia SA, Canales-Molina A (2006) Seroepidemiology of Toxoplasma gondii infection in pregnant women in a public hospital in northern Mexico. BMC Infect Dis 6:113

    Article  PubMed  PubMed Central  Google Scholar 

  • Ambroise-Thomas P, Petersen E (2000) Congenital toxoplasmosis. Scientific background, clinical management and control. Springer, Paris, pp 271–275

    Google Scholar 

  • Asthana SP, Macpherson CN, Weiss SH, Stephens R, Denny TN, Sharma RN, Dubey JP (2006) Seroprevalence of Toxoplasma gondii in pregnant women and cats in Grenada, West Indies. J Parasitol 92:644–645

    Article  PubMed  Google Scholar 

  • Baril L, Ancelle T, Goulet V, Thulliez P, Tirard-Fleury V, Carme B (1999) Risk factors for Toxoplasma infection in pregnancy: a case-control study in France. Scand J Infect Dis 31(3):305–309

    Article  CAS  PubMed  Google Scholar 

  • Barrera AM, Castiblanco P, Gomez JE, Lopez MC, Ruiz A, Moncada L, Reyes P, Corredor A (2002) Toxoplasmosis adquirida durante el embarazo, en el Instituto Materno Infantil en Bogota. Rev Salud Publica 4:286–293

    Google Scholar 

  • Basavaraju A (2016) Toxoplasmosis in HIV infection: an overview. Trop Parasitol 6:129–135

    Article  PubMed  PubMed Central  Google Scholar 

  • Benenson MW, Takafuji ET, Lemon SM, Greenup RL, Sulzer AJ (1982) Oocyst-transmitted toxoplasmosis associated with ingestion of contaminated water. N Engl J Med 307:666–669

    Article  CAS  PubMed  Google Scholar 

  • Bertranpetit E, Jombart T, Paradis E, Pena H, Dubey J, Su C, Mercier A, Devillard S, Ajzenberg D (2017) Phylogeography of Toxoplasma gondii points to a South American origin. Infect Genet Evol 48:150–155

    Article  PubMed  Google Scholar 

  • Bigna JJ, Tochie JN, Tounouga DN, Bekolo AO, Ymele NS, Youda EL, Sime PS, Nansseu JR (2020) Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis. Sci Rep 10(1):12102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blaizot R, Nabet C, Blanchet D, Martin E, Mercier A, Dardé ML, Elenga N, Demar M (2019) Pediatric Amazonian toxoplasmosis caused by atypical strains in French Guiana, 2002–2017. Pediatr Infect Dis J 38(3):e39–e42

    Article  PubMed  Google Scholar 

  • Bonametti AM, Passos JN, Koga da Silva EM, Macedo ZS (1997) Probable transmission of acute toxoplasmosis through breast feeding. J Trop Pediatr 43(2):116–120

    Article  CAS  PubMed  Google Scholar 

  • Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, Withers S, Meier P, McLeod R, Toxoplasmosis Study Group (2005) Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol 192(2):564–571

    Article  PubMed  Google Scholar 

  • Cañón-Franco WA, López-Orozco N, Gómez-Marín JE, Dubey JP (2014) An overview of seventy years of research (1944–2014) on toxoplasmosis in Colombia, South America. Parasite Vectors 7:427

    Article  Google Scholar 

  • Carme B, Demar-Pierre M (2006) Toxoplasmosis in French Guiana. A typical (neo-)tropical features of a cosmopolitan parasitosis. Med Trop (Mars) 66:495–503

    CAS  Google Scholar 

  • Carme B, Bissuel F, Ajzenberg D et al (2002a) Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana. J Clin Microbiol 40:4037–4044

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carme B, Aznar C, Motard A et al (2002b) Serologic survey of Toxoplasma gondii in noncarnivorous free-ranging neotropical mammals in French Guiana. Vector Borne Zoonotic Dis 2:11–17

    Article  CAS  PubMed  Google Scholar 

  • Carme B, Demar M, Ajzenberg D et al (2009) Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French Guiana. Emerg Infect Dis 15:656–658

    Article  PubMed  PubMed Central  Google Scholar 

  • Cenci-Goga BT, Rossitto PV, Sechi P, McCrindle CM, Cullor JS (2011) Toxoplasma in animals, food, and humans: an old parasite of new concern. Foodborne Pathog Dis 8:751–762

    Article  PubMed  Google Scholar 

  • Chiari Cde A, Neves DP (1984) Human toxoplasmosis acquired by ingestion of goat's milk. Mem Inst Oswaldo Cruz 79(3):337–340

    PubMed  Google Scholar 

  • Christoph J, Kattner E, Seitz HM, Reiter-Owona I (2004) Strategien zur Diagnostik und Behandlung der pränatalen Toxoplasma-Infektion. Z Geburtshilfe Neonatol 208:10–16

    Article  CAS  PubMed  Google Scholar 

  • Connolly MP, Goodwin E, Schey C, Zummo J (2017) Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis. Pathog Glob Health 111(1):31–44

    Google Scholar 

  • Crouch EEV, Mittel LD, Southard TL, Cerqueira-Cézar CK, Murata FHA, Kwok OCH, Su C, Dubey JP (2019) Littermate cats rescued from a shelter succumbed to acute, primary toxoplasmosis associated with TOXO DB genotype #4, generally circulating in wildlife. Parasitol Int 72:101942

    Article  CAS  PubMed  Google Scholar 

  • da Costa MA, Pinto-Ferreira F, de Almeida RPA, Martins FDC, Pires AL, Mareze M, Mitsuka-Breganó R, Freire RL, da Rocha Moreira RV, Borges JM, Navarro IT (2020) Artisan fresh cheese from raw cow's milk as a possible route of transmission in a toxoplasmosis outbreak, in Brazil. Zoonoses Public Health 67:122–129

    Article  PubMed  CAS  Google Scholar 

  • da Silva RC, Langoni H (2009) Toxoplasma gondii: host-parasite interaction and behavior manipulation. Parasitol Res 105(4):893–898

    Article  PubMed  Google Scholar 

  • Dard C, Marty P, Brenier-Pinchart MP, Garnaud C, Fricker-Hidalgo H, Pelloux H, Pomares C (2018) Management of toxoplasmosis in transplant recipients: an update. Expert Rev Anti-Infect Ther 16(6):447–460

    Article  CAS  PubMed  Google Scholar 

  • Davidson MG (2000) Toxoplasmosis. Vet Clin North Am Small Anim Pract 30:1051–1062

    Article  CAS  PubMed  Google Scholar 

  • De La Fuente Villar BB, Neves ES, Louro VC, Lessa JF, Rocha DN, Gomes LHF, Junior SCG, Pereira JP Jr, Moreira MEL, Guida LDC (2020) Toxoplasmosis in pregnancy: a clinical, diagnostic, and epidemiological study in a referral hospital in Rio de Janeiro, Brazil. Braz J Infect Dis 24:517–523

    Article  Google Scholar 

  • de Quadros RM, da Rocha GC, Romagna G, de Oliveira JP, Ribeiro DM, Marques SM (2015) Toxoplasma gondii seropositivity and risk factors in pregnant women followed up by the family health strategy. Rev Soc Bras Med Trop 48(3):338–342

    Article  PubMed  Google Scholar 

  • Demar M, Ajzenberg D, Maubon D et al (2007) Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspects. Clin Infect Dis 45:e88–e95

    Article  PubMed  Google Scholar 

  • Demar M, Hommel D, Djossou F et al (2012) Acute toxoplasmosis in immunocompetent patients hospitalized in an intensive care unit in French Guiana. Clin Microbiol Infect 18:E221–E231

    Article  CAS  PubMed  Google Scholar 

  • Desmettre T (2020) Toxoplasmosis and behavioural changes. J Fr Ophtalmol 43(3):e89–e93

    Article  CAS  PubMed  Google Scholar 

  • Diesel AA, Zachia SA, Müller ALL, Perez AV, Uberti FAF, Magalhães JAA (2019) Follow-up of toxoplasmosis during pregnancy: ten-year experience in a university hospital in southern Brazil. Rev Bras Ginecol Obstet 41:539–547

    Article  PubMed  Google Scholar 

  • Dubey JP (2009) Toxoplasmosis of animals and humans. Parasites and vectors. CRC Press, Boca Raton

    Google Scholar 

  • Dubey JP, Miller NL, Frenkel JK (1970) Toxoplasma gondii life cycle in cats. J Am Vet Med Assoc 157(11):1767–1770

    CAS  PubMed  Google Scholar 

  • Dubey JP, Gomez-Marin JE, Bedoya A, Lora F, Vianna MC, Hill D, Kwok OC, Shen SK, Marcet PL, Lehmann T (2005) Genetic and biologic characteristics of Toxoplasma gondii isolates in free-range chickens from Colombia, South America. Vet Parasitol 134:67–72

    Article  CAS  PubMed  Google Scholar 

  • Dubey JP, Lago EG, Gennari SM, Su C, Jones JL (2012) Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology. Parasitology 139:1375–1424

    Article  CAS  PubMed  Google Scholar 

  • Dubremetz JF (2007) Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction. Cell Microbiol 9:841–848

    Article  CAS  PubMed  Google Scholar 

  • Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG (2018) Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice. Clin Microbiol Rev 31(4):e00057–e00017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Edelhofer R, Prossinger H (2010) Infection with Toxoplasma gondii during pregnancy: seroepidemiological studies in Austria. Zoonoses Public Health 57(1):18–26

    Article  CAS  PubMed  Google Scholar 

  • El Bissati K, Levigne P, Lykins J, Adlaoui EB, Barkat A, Berraho A, Laboudi M, El Mansouri B, Ibrahimi A, Rhajaoui M, Quinn F, Murugesan M, Seghrouchni F, Gómez-Marín JE, Peyron F, McLeod R (2018) Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis. Emerg Microbes Infect 7(1):165

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferguson DJ (2009) Toxoplasma gondii: 1908–2008, homage to Nicolle, Manceaux and Splendore. Mem Inst Oswaldo Cruz 104:133–148

    Article  PubMed  Google Scholar 

  • Flegr J, Prandota J, Sovičková M, Israili ZH (2014) Toxoplasmosis–a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One 9(3):e90203

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Frenkel JK (2000) Biology of Toxoplasma gondii. In: Ambroise-Thomas P, Petersen E (eds) Congenital toxoplasmosis. Scientific background, clinical management and control. Springer, Paris

    Google Scholar 

  • Frenkel JK, Dubey JP, Miller NL (1970) Toxoplasma gondii fecal stages identified as coccidian oocysts. Science 167:893–896

    Article  CAS  PubMed  Google Scholar 

  • Garweg JG (2016) Ocular toxoplasmosis: an update. Klin Monatsbl Augenheilkd 233:534–539

    Article  CAS  PubMed  Google Scholar 

  • Gilbert RE, Freeman K, Lago EG, Bahia-Oliveira LM, Tan HK, Wallon M, Buffolano W, Stanford MR, Petersen E, European Multicentre Study on Congenital Toxoplasmosis (EMSCOT) (2008) Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Negl Trop Dis 2(8):e277

    Article  PubMed  PubMed Central  Google Scholar 

  • Gómez Marín JE, Zuluaga JD, Pechené Campo EJ, Triviño J, de-la- Torre A (2018) Polymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American setting. Acta Trop 184:83–87

    Article  PubMed  CAS  Google Scholar 

  • Gómez-Marin JE, de-la-Torre A, Angel-Muller E, Rubio J, Arenas J, Osorio E, Nuñez L, Pinzon L, Mendez-Cordoba LC, Bustos A, de-la-Hoz I, Silva P, Beltran M, Chacon L, Marrugo M, Manjarres C, Baquero H, Lora F, Torres E, Zuluaga OE, Estrada M, Moscote L, Silva MT, Rivera R, Molina A, Najera S, Sanabria A, Ramirez ML, Alarcon C, Restrepo N, Falla A, Rodriguez T, Castaño G (2011) First Colombian multicentric newborn screening for congenital toxoplasmosis. PLoS Negl Trop Dis 5(5):e1195

    Google Scholar 

  • Gontijo da Silva M, Clare Vinaud M, de Castro AM (2015) Prevalence of toxoplasmosis in pregnant women and vertical transmission of Toxoplasma gondii in patients from basic units of health from Gurupi, Tocantins, Brazil, from 2012 to 2014. PLoS One 10(11):e0141700

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gross U (ed) (1996) Toxoplasma gondii. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Grossklaus D, Baumgarten HJC (1967) The survival period of Toxoplasma stages in meat of pigs. Fleischwirtschaft 47:1372–1378

    Google Scholar 

  • Halonen SK, Weiss LM (2013) Toxoplasmosis. Handb Clin Neurol 114:125–145

    Article  PubMed  PubMed Central  Google Scholar 

  • Hartmann K, Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hosie MJ, Lloret A, Lutz H, Marsilio F, Möstl K, Pennisi MG, Radford AD, Thiry E, Truyen U, Horzinek MC (2013) Toxoplasma gondii infection in cats: ABCD guidelines on prevention and management. J Feline Med Surg 15:631–637

    Article  PubMed  Google Scholar 

  • Heukelbach J, Meyer-Cirkel V, Moura RC, Gomide M, Queiroz JA, Saweljew P, Liesenfeld O (2007) Waterborne toxoplasmosis, northeastern Brazil. Emerg Infect Dis 13(2):287–289

    Article  PubMed  PubMed Central  Google Scholar 

  • Hill DE, Dubey JP (2016) Toxoplasma gondii as a parasite in food: analysis and control. Microbiol. Spectrum 4(4):PFS-0011-2015

    Google Scholar 

  • Hill DE, Chirukandoth S, Dubey JP (2005) Biology and epidemiology of Toxoplasma gondii in man and animals. Anim Health Res Rev 6:41–61

    Article  PubMed  Google Scholar 

  • Jamra LM, Martins MC, Vieira Mde P (1991) Effect of table salt on Toxoplasma gondii. Rev Inst Med Trop Sao Paulo 33(5):359–363

    Article  CAS  PubMed  Google Scholar 

  • Janssen P, Piekarski G, Korte W (1970) Abortion in women with latent Toxoplasma infections. Klin Wochenschr 48:25–30

    Article  CAS  PubMed  Google Scholar 

  • Jones JL, Dubey JP (2012) Food borne toxoplasmosis. Clin Inf Dis 55:845–851

    Article  Google Scholar 

  • Jones JL, Kruszon-Moran D, Sanders-Lewis K, Wilson M (2007) Toxoplasma gondii infection in the United States, 1999–2004, decline from the prior decade. Am J Trop Med Hyg 77:405–410

    Article  PubMed  Google Scholar 

  • Kaye A (2011) Toxoplasmosis: diagnosis, treatment, and prevention in congenitally exposed infants. J Pediatr Health Care 25:355–264

    Article  PubMed  Google Scholar 

  • Khan K, Khan W (2018) Congenital toxoplasmosis: an overview of the neurological and ocular manifestations. Parasitol Int 67:715–721

    Article  PubMed  Google Scholar 

  • Kim K, Weiss LM (2008) Toxoplasma: the next 100 years. Microbes Infect 10:978–984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lago EG, Conrado GS, Piccoli CS, Carvalho RL, Bender AL (2009) Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis. Eur J Clin Microbiol Infect Dis 28:345–351

    Article  CAS  PubMed  Google Scholar 

  • Lambooij MS, Veldwijk J, van Gils P, Mangen MJ, Over E, Suijkerbuijk A, Polder J, de Wit GA, Opsteegh M (2019) Consumers’ preferences for freezing of meat to prevent toxoplasmosis- a stated preference approach. Meat Sci 149:1–8

    Article  PubMed  Google Scholar 

  • Luna JC, Zamora A, Hernández-Arango N, Muñoz-Sánchez D, Pinzón MI, Cortés-Vecino JA, Lora-Suarez F, Gómez-Marín JE (2019) Food safety assessment and risk for toxoplasmosis in school restaurants in Armenia, Colombia. Parasitol Res 118:3449–3457

    Article  PubMed  Google Scholar 

  • Mandelbrot L, Kieffer F, Sitta R, Laurichesse-Delmas H, Winer N, Mesnard L, Berrebi A, Le Bouar G, Bory JP, Cordier AG, Ville Y, Perrotin F, Jouannic JM, Biquard F, d'Ercole C, Houfflin-Debarge V, Villena I, Thiébaut R, TOXOGEST Study Group (2018) Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial. Am J Obstet Gynecol 219(4):386.e1–386.e9

    Article  CAS  Google Scholar 

  • Marquez MDLA, Etcheverry IS (2003) Seroprevalence of toxoplasmosis in pregnant women in La Plata area. Acta Bioquim Clin Latinoam 37:413–415

    Google Scholar 

  • Mehlhorn H (2016a) Animal parasites. Springer International, Switzerland

    Book  Google Scholar 

  • Mehlhorn H (2016b) Human parasites. Springer International, Switzerland

    Book  Google Scholar 

  • Mehlhorn H (ed) (2016c) Encyclopedia of parasitology. 4th ed., Springer Berlin, Heidelberg

    Google Scholar 

  • Mehlhorn H, Klimpel S (eds) (2019) Parasite and disease spread by major rivers on earth. Past and future perspectives. Springer, Berlin, New York

    Google Scholar 

  • Mehlhorn T (2018) Analyse der Immunantwort gegen intrazelluläre Pathogene in der GBP2-defizienten Mauslinie. Doktor dissertation, Heinrich Heine University, Düsseldorf

    Google Scholar 

  • Mirza Alizadeh A, Jazaeri S, Shemshadi B, Hashempour-Baltork F, Sarlak Z, Pilevar Z, Hosseini H (2018) A review on inactivation methods of Toxoplasma gondii in foods. Pathog Glob Health 112(6):306–319

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Montoya JG, Remington JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 47(4):554–566

    Article  PubMed  Google Scholar 

  • Moura IPDS, Ferreira IP, Pontes AN, Bichara CNC (2019) Toxoplasmosis knowledge and preventive behavior among pregnant women in the city of Imperatriz, Maranhao, Brazil. Cien Saude Colet 24:3933–3946

    Article  PubMed  Google Scholar 

  • Murillo-León M, Müller UB, Zimmermann I, Singh S, Widdershooven P, Campos C, Alvarez C, Könen-Waisman S, Lukes N, Ruzsics Z, Howard JC, Schwemmle M, Steinfeldt T (2019) Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice. Nat Commun 10(1):1233

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Navarro IT, Vidotto O, Giraldi N, Mitsuka R (1992) Resistance of Toxoplasma gondii to sodium chloride and condiments in pork sausage. Bol Oficina Sanit Panam 112(2):138–143

    CAS  PubMed  Google Scholar 

  • Ngoungou EB, Bhalla D, Nzoghe A, Dardé ML, Preux PM (2015) Toxoplasmosis and epilepsy—systematic review and meta analysis. PLoS Negl Trop Dis 9(2):e0003525

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nicolle C, Manceaux G (1908) Sur une infection a corps de Leishman (ou organismvoirsins) du gondi. C R Acad Sci 147:736

    Google Scholar 

  • Nicolle C, Manceaux G (1909) Sur une protozoaire nouveau du gondi. C R Acad Sci 148:369

    Google Scholar 

  • Olbrich Neto J, Meira DA (2004) Seroprevalence of HTLV-I/II, HIV, syphilis and toxoplasmosis among pregnant women seen at Botucatu–Sao Paulo–Brazil: risk factors for HTLV-I/II infection. Rev Soc Bras Med Trop 37:28–32

    Article  PubMed  Google Scholar 

  • Oliveira GMS, Simões JM, Schaer RE, Freire SM, Nascimento RJM, Pinheiro AMCM, Carvalho SMS, Mariano APM, Carvalho RC, Munhoz AD (2019) Frequency and factors associated with Toxoplasma gondii infection in pregnant women and their pets in Ilheus, Bahia, Brazil. Rev Soc Bras Med Trop 52:e20190250

    Article  PubMed  Google Scholar 

  • Overdulve JP (1970) The identity of Toxoplasma Nicolle and Manceaux, 1909 with Isospora Schneider, 1881. Proc K Ned Akad Wet C 73(1):138–151

    Google Scholar 

  • Pappas G, Roussos N, Falagas ME (2009) Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 39:1385–1394

    Article  PubMed  Google Scholar 

  • Pardini L, Bernstein M, Carral LA, Kaufer FJ, Dellarupe A, Gos ML, Campero LM, Moré G, Messina MT, Schneider MV, Freuler CB, Durlach RA, Unzaga JM, Venturini MC (2019) Congenital human toxoplasmosis caused by non-clonal Toxoplasma gondii genotypes in Argentina. Parasitol Int 68:48–52

    Article  PubMed  Google Scholar 

  • Petersen E, Kijlstra A, Stanford M (2012) Epidemiology of ocular toxoplasmosis. Ocul Immunol Inflamm 20:68–75

    Article  PubMed  Google Scholar 

  • Piekarski G, Witte HM (1970) The agents of toxoplasmosis: a specific parasite of cats. Umschau 11:342–343

    Google Scholar 

  • Pinto-Ferreira F, Caldart ET, Pasquali AKS, Mitsuka-Breganó R, Freire RL, Navarro IT (2019) Patterns of transmission and sources of infection in outbreaks of human toxoplasmosis. Emerg Infect Dis 25(12):2177–2182

    Article  PubMed  PubMed Central  Google Scholar 

  • Pleyer U, Gross U, Schlüter D, Wilking H, Seeber F (2019) Toxoplasmosis in Germany. Dtsch Arztebl Int 116:435–444

    PubMed  PubMed Central  Google Scholar 

  • Porto AM, Amorim MM, Coelho IC, Santos LC (2008) Serologic profile of toxoplasmosis in pregnant women attended at a teaching-hospital in Recife. Rev Assoc Med Bras (1992) 54(3):242–248

    Article  Google Scholar 

  • Rajapakse S, Weeratunga P, Rodrigo C, de Silva NL, Fernando SD (2017) Prophylaxis of human toxoplasmosis: a systematic review. Pathog Glob Health 111:333–342

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rajendran C, Su C, Dubey JP (2012) Molecular genotyping of Toxoplasma gondii from central and South America revealed high diversity within and between populations. Infect Genet Evol 12:359–368

    Article  CAS  PubMed  Google Scholar 

  • Ramanan P, Scherger S, Benamu E, Bajrovic V, Jackson W, Hage CA, Hakki M, Baddley JW, Abidi MZ (2020) Toxoplasmosis in non-cardiac solid organ transplant recipients: a case series and review of literature. Transpl Infect Dis 22(1):e13218

    Article  PubMed  Google Scholar 

  • Ramsewak S, Gooding R, Ganta K, Seepersadsingh N, Adesiyun AA (2008) Seroprevalence and risk factors of Toxoplasma gondii infection among pregnant women in Trinidad and Tobago. Rev Panam Salud Publica 23:164–170

    Article  PubMed  Google Scholar 

  • Reis MM, Tessaro MM, D’Azevedo PA (2006) Serologic profile of toxoplasmosis in pregnant women from a public hospital in Porto Alegre. Rev Bras Ginecol Obstet 28:158–164

    Google Scholar 

  • Reiter-Owona I, Bialek R, Rockstroh JK, Seitz HM (1998) The probability of acquiring primary Toxoplasma infection in HIV-infected patients: results of an 8-year retrospective study. Infection 26(1):20–25

    Article  CAS  PubMed  Google Scholar 

  • Rey LC, Ramalho IL (1999) Seroprevalence of toxoplasmosis in Fortaleza, Ceara, Brazil. Rev Inst Med Trop Sao Paulo 41:171–174

    Article  CAS  PubMed  Google Scholar 

  • Rickard E, Costagliola M, Outen E, Cicero M, Garcia G, Dieguez N (1999) Toxoplasmosis antibody prevalence in pregnancy in Buenos Aires province, Argentina. Clin Microbiol Infect 5(Suppl 3):171

    Google Scholar 

  • Robert-Gangneux F, Belaz S (2016) Molecular diagnosis of toxoplasmosis in immunocompromised patients. Curr Opin Infect Dis 29:330–339

    Article  PubMed  Google Scholar 

  • Robert-Gangneux F, Dardé ML (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25:264–296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rosso F, Les JT, Agudelo A, Villalobos C, Chaves JA, Tunubala GA, Messa A, Remington JS, Montoya JG (2008) Prevalence of infection with Toxoplasma gondii among pregnant women in Cali, Colombia, South America. Am J Trop Med Hyg 78:504–508

    Article  PubMed  Google Scholar 

  • Rostami A, Riahi SM, Gamble HR, Fakhri Y, Nourollahpour Shiadeh M, Danesh M, Behniafar H, Paktinat S, Foroutan M, Mokdad AH, Hotez PJ, Gasser RB (2020) Global prevalence of latent toxoplasmosis in pregnant women: a systematic review and meta-analysis. Clin Microbiol Infect 26(6):673–683

    Article  CAS  PubMed  Google Scholar 

  • Rudzinski M, Khoury M, Couto C, Ajzenberg D (2016) Reactivation of ocular toxoplasmosis in non-Hispanic persons, Misiones Province, Argentina. Emerg Infect Dis 22:912–913

    Article  PubMed  PubMed Central  Google Scholar 

  • Sabin AB (1942) Toxoplasmosis: a recently recognized disease of human beings. Adv Pediatr 1:1–60

    Google Scholar 

  • Sabin AB, Feldman HA (1948) Dyes as microchemical indicators of a new immunity phenomenon affecting a protozoon parasite (Toxoplasma). Science 108:660–663

    Article  CAS  PubMed  Google Scholar 

  • Sabin AB, Olitski PK (1937) Toxoplasma and obligate intracellular parasitism. Science 85:336–338

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Gutierrez A, Martin-Hernandez I, Garcia-Izquierdo SM (2003) Estudio de reactividad a Toxoplasma gondii en embarazadas de las provincias Ciudad de la Habana y Pinardel Rio, Cuba. Bioquimia 28:3–8

    Google Scholar 

  • Sauer A, de la Torre A, Gomez-Marin J, Bourcier T, Garweg J, Speeg-Schatz C, Candolfi E (2011) Prevention of retinochoroiditis in congenital toxoplasmosis: Europe versus South America. Pediatr Infect Dis J 30:601–603

    Article  PubMed  Google Scholar 

  • Schlaen A, Colombero D, Ormaechea S, Ladeveze E, Rudzinski C, Ingolotti M, Couto C, Rudzinski M (2019) Regional differences in the clinical manifestation of ocular toxoplasmosis between the center and northeast of Argentina. Ocul Immunol Inflamm 27:722–730

    Article  PubMed  Google Scholar 

  • Schlüter D, Barragan A (2019) Advances and challenges in understanding cerebral toxoplasmosis. Front Immunol 10:242

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Scholtyseck E, Mehlhorn H (1970) Ultrastructural study of characteristic organelles (paired organelles, micronemes, micropores) of sporozoa and related organisms. Z Parasitenkd (Parasitol Res) 34(2):97–127

    CAS  Google Scholar 

  • Scholtyseck E, Mehlhorn H, Hammond DM (1972) Electron microscope studies of microgametogenesis in Coccidia and related groups. Z Parasitenkd (Parasitol Res) 38(2):95–131

    Article  CAS  Google Scholar 

  • Shuralev EA, Shamaev ND, Mukminov MN, Nagamune K, Taniguchi Y, Saito T, Kitoh K, Arleevskaya MI, Fedotova AY, Abdulmanova DR, Aleksandrova NM, Efimova MA, Yarullin AI, Valeeva AR, Khaertynov KS, Takashima Y (2018) Toxoplasma gondii seroprevalence in goats, cats and humans in Russia. Parasitol Int 67(2):112–114

    Article  PubMed  Google Scholar 

  • Sibley LD, Khan A, Ajioka JW, Rosenthal BM (2009) Genetic diversity of toxoplasma gondii in animals and humans. Philos Trans R Soc Lond Ser B Biol Sci 364(1530):2749–2761

    Article  Google Scholar 

  • Silva LA, Fernandes MD, Machado AS, Reis-Cunha JL, Bartholomeu DC, Almeida Vitor RW (2019) Efficacy of sulfadiazine and pyrimethamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol 202:7–14

    Article  CAS  PubMed  Google Scholar 

  • Soares JAS, Caldeira AP (2019) Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease. Rev Soc Bras Med Trop 52:e20180228

    Article  PubMed  Google Scholar 

  • Spalding SM, Amendoeira MR, Klein CH, Ribeiro LC (2005) Serological screening and toxoplasmosis exposure factors among pregnant women in south of Brazil. Rev Soc Bras Med Trop 38:173–177

    Article  PubMed  Google Scholar 

  • Splendore A (1908) Un buovo protozoa parassita de conigli incontrato nelle lessioni anatomiche d’ une mallattia che ricorda in molti punti il Kala-azar dell’ uoma. Rev Soc Sci Sao Paulo 3:109–112

    Google Scholar 

  • Strang AGGF, Ferrari RG, do Rosário DK, Nishi L, Evangelista FF, Santana PL, de Souza AH, Mantelo FM, Guilherme ALF (2020) The congenital toxoplasmosis burden in Brazil: systematic review and meta-analysis. Acta Trop 211:105608

    Article  PubMed  Google Scholar 

  • Tenter AM (2009) Toxoplasma gondii in animals used for human consumption. Mem Inst Oswaldo Cruz 104:364–369

    Article  PubMed  Google Scholar 

  • Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30(12–13):1217–1258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Torgerson PR, Mastroiacovo P (2013) The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ 91(7):501–508

    Article  PubMed  PubMed Central  Google Scholar 

  • Torrey EF, Yolken RH (2007) Schizophrenia and toxoplasmosis. Schizophr Bull 33(3):727–728

    Article  PubMed  PubMed Central  Google Scholar 

  • Triolo-Mieses M, Traviezo-Valles L (2006) Serological prevalence of Toxoplasma gondii antibodies in pregnancy in Palavecino municipality. Lara State, Venezuela. Kasmera 34:7–13

    Google Scholar 

  • Varella IM, Wagner MB, Darela AC, Nunes LM, Muller RW (2003) Seroprevalence of toxoplasmosis in pregnant women. J Pediatr 79:69–74

    Google Scholar 

  • Velásquez Serra GC, Piloso Urgiles LI, Guerrero Cabredo BP, Chico Caballero MJ, Zambrano SL, Yaguar Gutierrez EM, Barrera Reyes CG (2020) Current situation of congenital toxoplasmosis in Ecuador. J Community Health 45(1):170–175

    Article  PubMed  Google Scholar 

  • Wallace MR, Rossetti RJ, Olson PE (1993) Cats and toxoplasmosis risk in HIV-infected adults. JAMA 269(1):76–77

    Article  CAS  PubMed  Google Scholar 

  • Wallochnik J (2011) Parasites: unwished guests in human bodies. Ueberreuter Publisher, Vienna

    Google Scholar 

  • Wei HX, Wei SS, Lindsay DS, Peng HJ (2015) A systematic review and meta-analysis of the efficacy of anti-Toxoplasma gondii medicines in humans. PLoS One 10(9):e0138204

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wolf A, Cowen D (1937) Granulomatous encephalomyelitis due to an encephalitozoon (encephalitic ancephalomyelitis): a new protozoan disease of man. Bull Neurol Inst NY 6:306–335

    Google Scholar 

  • Wolf A, Cowen D, Paige B (1939) Human toxoplasmosis: occurrence in infants as encephalomyelitis verification by transmission to animals. Science 89:226–227

    Article  CAS  PubMed  Google Scholar 

  • Wyrosdick HM, Schaefer JJ (2015) Toxoplasma gondii: history and diagnostic test development. Anim Health Res Rev 16(2):150–162

    Article  PubMed  Google Scholar 

  • Zapata M, Reyes L, Holst I (2005) Decreased prevalence of toxoplasma gondii antibodies in adults form the Central Valley in Costa Rica. Parasitol Latinoam 60:32–37

    Article  Google Scholar 

  • Zhang K, Lin G, Han Y, Li J (2016) Serological diagnosis of toxoplasmosis and standardization. Clin Chim Acta 461:83–89

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Parasitology, Heinrich Heine University, Düsseldorf, Germany

    Heinz Mehlhorn

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  1. Department of Parasitology, Heinrich Heine University, Düsseldorf, Germany

    Heinz Mehlhorn

  2. Departamento de Saúde Comunitária, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil

    Jorg Heukelbach

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Mehlhorn, H. (2022). Toxoplasmosis in South America. In: Mehlhorn, H., Heukelbach, J. (eds) Infectious Tropical Diseases and One Health in Latin America. Parasitology Research Monographs, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-030-99712-0_7

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