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Cancer Metastasis Through the Lymphovascular System pp 121–128Cite as

Circulating Tumor Cells and ctDNA in Sarcomas

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Abstract

Sarcomas are clustered in two oncological entities named bone and soft tissue sarcomas. Both are rare cancers originating from the mesenchyme, characterized by their propensity to induce the development of lung metastases. Sarcoma cells escaping from the primary tumor site spread to the pulmonary tissue through the bloodstream where they found a favorable microenvironment to establish metastatic foci. The low number of patients, the high histological, genetic, and molecular heterogeneity of sarcomas combined with the absence of specific markers expressed by cancer cells make the detection and follow-up of the minimal residual disease challenging. Over the last decade, tremendous technological progress has been made towards the detection of recurrent diseases. The literature is now enriched of information describing the use of liquid biopsies in clinical care of sarcoma patients. This chapter aims to give a brief overview of the most recent data available on the detection of circulating tumor cells and circulating tumor DNA in sarcomas.

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Acknowledgments

The authors are also grateful to M. Clément Heymann for reviewing the English style.

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Authors and Affiliations

  1. Nantes Université, CNRS, US2B, UMR 6286, Institut de Cancérologie de l’Ouest, Blvd Jacques Monod, Saint-Herblain, France

    Camille Jubelin, Denis Cochonneau, Emilie Moranton, Javier Muñoz-Garcia & Dominique Heymann

  2. Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

    Dominique Heymann

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  1. Camille Jubelin
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  2. Denis Cochonneau
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  4. Javier Muñoz-Garcia
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Correspondence to Dominique Heymann .

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Editors and Affiliations

  1. Department of Surgery and Melanoma Center, California Pacific Medical Center and Research Institute, San Francisco, CA, USA

    Stanley P. Leong

  2. Henry Ford Cancer Institute, Detroit, MI, USA

    S. David Nathanson

  3. Moffitt Cancer Center, Tampa, FL, USA

    Jonathan S. Zager

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Jubelin, C., Cochonneau, D., Moranton, E., Muñoz-Garcia, J., Heymann, D. (2022). Circulating Tumor Cells and ctDNA in Sarcomas. In: Leong, S.P., Nathanson, S.D., Zager, J.S. (eds) Cancer Metastasis Through the Lymphovascular System. Springer, Cham. https://doi.org/10.1007/978-3-030-93084-4_12

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