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Bacteriospermia and Male Infertility: Role of Oxidative Stress

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1358))

Abstract

Male infertility is one of the major challenging and prevalent diseases having diverse etiologies of which bacteriospermia play a significant role. It has been estimated that approximately 15% of all infertility cases are due to infections caused by uropathogens and in most of the cases bacteria are involved in infection and inflammation leading to the development of bacteriospermia. In response to bacterial load, excess infiltration of leukocytes in the urogenital tract occurs and concomitantly generates oxidative stress (OS). Bacteria may induce infertility either by directly interacting with sperm or by generating reactive oxygen species (ROS) and impair sperm parameters such as motility, volume, capacitation, hyperactivation. They may also induce apoptosis leading to sperm death. Acute bacteriospermia is related with another clinical condition called leukocytospermia and both compromise male fertility potential by OS-mediated damage to sperm leading to male infertility. However, bacteriospermia as a clinical condition as well as the mechanism of action remains poorly understood, necessitating further research in order to understand the role of individual bacterial species and their impact in male infertility.

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Authors and Affiliations

  1. Department of Life Science and Bioinformatics, Assam University, Silchar, India

    Sandipan Das & Shubhadeep Roychoudhury

  2. Department of Human Physiology, Ambedkar College, Fatikroy, Tripura, India

    Anwesha Dey

  3. Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, India

    Niraj Kumar Jha

  4. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, India

    Dhruv Kumar

  5. Department of Microbiology, R. G. Kar Medical College and Hospital, Kolkata, India

    Shatabhisha Roychoudhury

  6. Health Centre, Assam University, Silchar, India

    Shatabhisha Roychoudhury

  7. Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic

    Petr Slama

  8. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo, Finland

    Kavindra Kumar Kesari

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  1. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo, Finland

    Kavindra Kumar Kesari

  2. Department of Life Science and Bioinformatics, Assam University, Silchar, India

    Shubhadeep Roychoudhury

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Das, S. et al. (2022). Bacteriospermia and Male Infertility: Role of Oxidative Stress. In: Kesari, K.K., Roychoudhury, S. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1358. Springer, Cham. https://doi.org/10.1007/978-3-030-89340-8_7

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