Abstract
Coronary CT angiography (cCTA) is an alternative imaging modality to functional stress testing in patients with reasonable clinical suspicion of nonacute ischemia or acute coronary syndromes (ACS) without definite objective evidence of ACS on EKG or myocardial necrosis by biomarkers. It allows a safe early discharge of patients presenting to the ED with chest pain. It is also useful when the stress test result is equivocal, when baseline ECG abnormalities are present, or when the patient is unable to walk. Cardiac CT can also assess the total coronary calcium burden and the calcium burden of each coronary artery. Coronary calcium has a weak correlation with the presence and severity of an angiographic stenosis, and thus it is most clinically reasonable to utilize in the decision to withhold, postpone, or initiate statin therapy if there is uncertainty about cardiovascular risk or if it is the patient preference to avoid statin therapy.
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Abbreviations
- ACS:
-
Acute coronary syndromes
- ASCVD:
-
Atherosclerotic cardiovascular disease
- CABG:
-
Coronary artery bypass graft
- CAC:
-
Coronary artery calcium
- CAD:
-
Coronary artery disease
- CAD-RADS:
-
Coronary Artery Disease-Reporting and Data System
- CCS:
-
Coronary calcium score
- cCTA:
-
Coronary computed tomography angiography
- CT:
-
Computed tomography
- ECG:
-
Electrocardiogram
- FFRCT:
-
Fractional flow reserve derived from computed tomography
- HU:
-
Hounsfield units
- ICA:
-
Invasive coronary angiography
- LM:
-
Left main
- MACE:
-
Major adverse cardiac events
- MDCT:
-
Multi-detector computed tomography
References
Taylor AJ, Cerqueira M, Hodgson JM, Mark D, Min J, O’Gara P, et al. ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American college of cardiology foundation appropriate use criteria task force, the society of cardiovascular computed tomography, the American college of radiology, the American heart association, the American society of echocardiography, the American society of nuclear cardiology, the north American society for cardiovascular imaging, the society for cardiovascular angiography and interventions, and the society for cardiovascular magnetic resonance. J Am Coll Cardiol. 2010;56(22):1864–94. https://doi.org/10.1016/j.jacc.2010.07.005.
Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol. 2008;52(21):1724–32. https://doi.org/10.1016/j.jacc.2008.07.031.
Meijboom WB, Meijs MF, Schuijf JD, Cramer MJ, Mollet NR, van Mieghem CA, et al. Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol. 2008;52(25):2135–44. https://doi.org/10.1016/j.jacc.2008.08.058.
Miller JM, Rochitte CE, Dewey M, Arbab-Zadeh A, Niinuma H, Gottlieb I, et al. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med. 2008;359(22):2324–36. https://doi.org/10.1056/NEJMoa0806576.
Douglas PS, Hoffmann U. Anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;373(1):91. https://doi.org/10.1056/NEJMc1505594.
Investigators S-H, Newby DE, Adamson PD, Berry C, Boon NA, Dweck MR, et al. Coronary CT angiography and 5-year risk of myocardial infarction. N Engl J Med. 2018;379(10):924–33. https://doi.org/10.1056/NEJMoa1805971.
Puchner SB, Liu T, Mayrhofer T, Truong QA, Lee H, Fleg JL, et al. High-risk plaque detected on coronary CT angiography predicts acute coronary syndromes independent of significant stenosis in acute chest pain: results from the ROMICAT-II trial. J Am Coll Cardiol. 2014;64(7):684–92. https://doi.org/10.1016/j.jacc.2014.05.039.
Goldstein JA, Chinnaiyan KM, Abidov A, Achenbach S, Berman DS, Hayes SW, et al. The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) trial. J Am Coll Cardiol. 2011;58(14):1414–22. https://doi.org/10.1016/j.jacc.2011.03.068.
Litt HI, Gatsonis C, Snyder B, Singh H, Miller CD, Entrikin DW, et al. CT angiography for safe discharge of patients with possible acute coronary syndromes. N Engl J Med. 2012;366(15):1393–403. https://doi.org/10.1056/NEJMoa1201163.
Hoffmann U, Truong QA, Schoenfeld DA, Chou ET, Woodard PK, Nagurney JT, et al. Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med. 2012;367(4):299–308. https://doi.org/10.1056/NEJMoa1201161.
Cury RC, Abbara S, Achenbach S, Agatston A, Berman DS, Budoff MJ, et al. CAD-RADS(TM) coronary artery disease - reporting and data system. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology. J Cardiovasc Comput Tomogr. 2016;10(4):269–81. https://doi.org/10.1016/j.jcct.2016.04.005.
Greenland P, Blaha MJ, Budoff MJ, Erbel R, Watson KE. Coronary calcium score and cardiovascular risk. J Am Coll Cardiol. 2018;72(4):434–47. https://doi.org/10.1016/j.jacc.2018.05.027.
Budoff MJ, Nasir K, McClelland RL, Detrano R, Wong N, Blumenthal RS, et al. Coronary calcium predicts events better with absolute calcium scores than age-sex-race/ethnicity percentiles: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2009;53(4):345–52. https://doi.org/10.1016/j.jacc.2008.07.072.
Rozanski A, Gransar H, Shaw LJ, Kim J, Miranda-Peats L, Wong ND, et al. Impact of coronary artery calcium scanning on coronary risk factors and downstream testing the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) prospective randomized trial. J Am Coll Cardiol. 2011;57(15):1622–32. https://doi.org/10.1016/j.jacc.2011.01.019.
Peng AW, Mirbolouk M, Orimoloye OA, Osei AD, Dardari Z, Dzaye O, et al. Long-term all-cause and cause-specific mortality in asymptomatic patients with CAC >/=1,000: results from the CAC consortium. JACC Cardiovasc Imaging. 2020;13(1 Pt 1):83–93. https://doi.org/10.1016/j.jcmg.2019.02.005.
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Lima, B.B., Patel, P., Gleason, P. (2022). Coronary CTA and Calcium Scoring. In: Bhargava, A.A., Wells, B.J., Quintero, P.A. (eds) Handbook of Outpatient Cardiology . Springer, Cham. https://doi.org/10.1007/978-3-030-88953-1_8
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