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Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases: Role of Ion Channels

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Cellular and Biochemical Mechanisms of Obesity

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 23))

Abstract

Circadian oscillators are the body’s biological clocks which exhibited in most of living organisms from bacteria to higher vertebrates. They are responsible for organizing a variety of biochemical and physiological cellular functions with a rhythmic period of a day cycle (24 h, circadian, repeat cycle in a day) even without any timing indicators. Any disruption in synchronization of circadian rhythm (chronodistruption) causes a wide range of complications which can be referred to as metabolic syndrome, obesity or type 2 diabetes mellitus (T2DM). Food intake can be stimulated because of its hedonic properties, although energy need is sufficiently provided. Addiction can be determined as excessive intake of either drug or food. Drug and food addiction shares some similar hedonic neuroadaptative properties in perception reward circuits. That could be as a result of childhood physical or psychological trauma by increasing neurotransmitter hypersensivity or dysregulation. Circadian clocks are key players of hormone synthesis and release, which cause cellular adaptations to the body environment. Ion channels are protein structured gate keepers located in the cell membrane, allowing charged ions to move across the membrane. They contribute and regulate many of cellular functions in the body. Ion channels act as an important player in circadian phases and also subsequent physiological functions by contributing in signaling pathway including homeostasis, gene expression, etc. Hence, this review focuses on the importance of chronobiology and its role on prevention of obesity, T2DM and regulation of the ion channels by circadian rhythm.

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Abbreviations

[Ca2+]i:

Intracellular calcium (Ca2+)

AITC:

Allyl isothiocyanate

AP:

Action potential

AT:

Adipose tissue

BAT:

Brown adipose tissue

BK:

Big conductance K+ channels

BMI:

Body mass index

Ca2+:

Calcium ion

CAPC:

Calcium activated K+ channels

CBT:

Core body temperature

CHD:

Coronary heart disease

CLOCK :

Circadian Kaput cycles

CVDs:

Cardiovascular diseases

DD:

Constant darkness

EE:

Energy expenditure

EPIC:

European Prospective Investigation into Cancer

ER:

Endoplasmic reticulum

FBG:

Fasting blood glucose

GIRK:

G protein gated inwardly rectifying K+ channels

GLP-1:

Glucagon-like peptide 1

GLUT-2:

Glucose transporter

GOF:

Gain of function

GSIS:

Glucose-stimulated insulin secretion

HFD:

High fat diet

HMGCoA:

Hydroxymethylglutaryl-CoA

ICAC:

Intermediate-conductance calcium-activated K+ channels

KK:

Knockout mice

LD:

Light-dark cycle

LDL:

Low-density lipoprotein

LOF:

Loss of function

MetS:

Metabolic syndrome

MODY:

Maturity onset diabetes of the young

MS:

Metabolic syndrome

PIP2:

Phosphatidylinositol 4,5-bisphosphate

POMC:

Proopiomelanocortin

PSG:

Polysomnogrephy

SCCA:

Small-conductance calcium-activated

SCN:

Suprachiasmatic nucleus

SD:

Standard deviation

SNP:

Single nucleotide polymorphism

SSTRs:

Somatostatin receptors

STZ:

Streptozotocin

SUR1:

Sulfonylurea receptor 1

T2D:

Type 2 diabetes

TRP:

Transient receptor potential channels

TT:

Sayfa 12 [1]

UCP-1:

Uncoupling protein 1

VDCC:

Voltage dependent Ca2+ channels

WAT:

White adipose tissue

WHR:

Waist to hip ratio

WT:

Wild type

α2-ADRs:

Adrenereceptors

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Acknowledgements

This work has supported by Junta de Extremadura grant (GR18040). Authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Biophysics, School of Medicine, Yozgat Bozok Univeristy, Yozgat, Turkey

    A. Cihangir Uguz

  2. Department of Physiology, Faculty of Science, University of Extremadura, 06006, Badajoz, Spain

    Lourdes Franco Hernandez, Ana Beatriz Rodriguez Moratinos & Jose Antonio Pariente Llanos

  3. School of Natural Sciences, University of Central Lancashire, Preston, UK

    Jaipaul Singh

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  1. A. Cihangir Uguz
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  5. Jose Antonio Pariente Llanos
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Correspondence to Jose Antonio Pariente Llanos .

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  1. St. Boniface Hospital Research, Asper Clinical Research Institute, Winnipeg, MB, Canada

    Paramjit S. Tappia

  2. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Bram Ramjiawan

  3. St. Boniface Hospital Research, Institute of Cardiovascular Science, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Uguz, A.C., Hernandez, L.F., Singh, J., Moratinos, A.B.R., Llanos, J.A.P. (2021). Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases: Role of Ion Channels. In: Tappia, P.S., Ramjiawan, B., Dhalla, N.S. (eds) Cellular and Biochemical Mechanisms of Obesity. Advances in Biochemistry in Health and Disease, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-030-84763-0_6

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