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Novel Techniques: Solid-State Detectors, Dose Reduction (SPECT/CT)

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Abstract

There has been an evolutionary leap in single photon emission computed tomography (SPECT) imaging with the advent of camera systems which utilize solid-state crystals and novel collimator designs configured specifically for cardiac imaging. Solid-state SPECT camera systems have facilitated dramatic reductions in both imaging time and radiation dose, while maintaining high diagnostic accuracy. These advances are related to simultaneous improvement in photon sensitivity due to the collimator and imaging geometry, as well as image resolution due to the improved energy resolution of the new crystals. Improved photon sensitivity has facilitated fast or low-dose myocardial perfusion imaging and early dynamic imaging has emerged as a technique for assessing myocardial blood flow with SPECT. Lastly, general-purpose solid-state camera systems and hybrid SPECT/CT systems have also been developed which may have important clinical roles in cardiac imaging. This review summarizes state-of-the-art solid-state SPECT myocardial perfusion imaging (MPI) technology and clinical applications, including emerging techniques for SPECT MPI flow estimation. We also discuss imaging protocols used with the new cameras, potential imaging pitfalls and review the latest data providing large-scale validation of the diagnostic and prognostic value of this new technology.

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Acknowledgements

This chapter contains material from the article Slomka et al. J Nucl Med. 2019 Sep;60 (9):1194–1204 Solid-State Detector SPECT Myocardial Perfusion Imaging. Reproduced with permission.

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Authors and Affiliations

  1. Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Piotr J. Slomka, Robert J. H. Miller, Lien-Hsin Hu & Daniel S. Berman

  2. Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada

    Robert J. H. Miller

  3. Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Lien-Hsin Hu

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  1. Piotr J. Slomka
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Correspondence to Piotr J. Slomka .

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  1. Department of Nuclear Medicine, Technical University Munich, Munich, Germany

    Stephan G. Nekolla

  2. Department of Nuclear Medicine, University of Duisburg-Essen, Essen, Nordrhein-Westfalen, Germany

    Christoph Rischpler

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Slomka, P.J., Miller, R.J.H., Hu, LH., Berman, D.S. (2022). Novel Techniques: Solid-State Detectors, Dose Reduction (SPECT/CT). In: Nekolla, S.G., Rischpler, C. (eds) Hybrid Cardiac Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-83167-7_7

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