Abstract
Liver transplantation is now the standard of care for children with end-stage liver disease, an increasing list of metabolic diseases and, more recently, liver tumours. It can also be used as pre-emptive treatment for some infants with metabolic diseases, where the enzyme defect resides in the liver without other structural liver dysmorphology. This chapter describes liver transplantation as it is conducted at a centre for paediatric liver disease. It is important to emphasize that liver replacement as treatment should be conducted in a setting of a multidisciplinary team specializing in all aspects of paediatric liver disease. Indications, assessment before surgery, surgical technique of donor organ procurement, split liver transplant, living donation and recipient liver explantation and insertion, are presented. Post-operative care including management of immunosuppression, post-transplant infections, surgical complications and long-term outcome are presented in detail.
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References
Brenner DA, Thomas E (2017) Starzl: transplantation pioneer. Proc Natl Acad Sci U S A 114:10808–10809
Charlton M et al (2018) International Liver Transplantation Society consensus statement on immunosuppression in liver transplant recipients. Transplantation 102:727–743
Cuenca AG et al (2017) Pediatric liver transplantation. Semin Pediatr Surg 26:217–223
de Ville de Goyet J et al (1995) Standardized quick en-bloc technique for procurement of cadaveric liver grafts for pediatric liver transplantation. Transpl Int 8:280–285
Ferreira-Meirelles R et al (2015) Liver transplantation: history, outcomes and perspectives. Einstein (Sao Paulo) 13:149–152
Fischler B et al (2019) Similarities and differences in allocation policies for pediatric liver transplantation across the world. J Pediatr Gastroenterol Nutr 68:700–705
Kochhar G et al (2013) Biliary complications following liver transplantation. World J Gastroenterol 19:2841–2846
Kohli R et al (2018) Liver transplantation in children: state of the art and future perspectives. Arch Dis Child 103:192–198
Mazariegos G et al (2014) Liver transplantation for pediatric metabolic disease. Mol Genet Metab 111:418–427
Miller C et al (1988) Rapid flush technique for donor hepatectomy: safety and efficacy of an improved method of liver recovery for transplantation. Transplant Proc 20:948–950
Montenovo MI et al (2019) Living liver donation improves patient and graft survival in the pediatric population. Pediatr Transplant 23:e13318. https://doi.org/10.1111/petr.13318
Otte JB (2002) History of pediatric liver transplantation. Where are we coming from? Where do we stand? PediatrTranspl 6:378–387
Ramos-Gonzales G et al (2019) Predictors of need for liver transplantation in children undergoing hepatoportoenterostomy for biliary atresia. J Pediatr Surg 54:1127–1131
Safinia N et al (2018) Cell therapy in organ transplantation: our experience on the clinical translation of regulatory T-cells. Front Immunol 9:e354. https://doi.org/10.3389/fimmu.2018.00354
Shneider BL (2002) Pediatric liver transplantation in metabolic disease: clinical decision making. Pediatr Transplant 6(1):25–29
Yersitz H et al (2003) One hundred in situ split-liver transplantations. A single center experience. Ann Surg 238:496–507
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Sharif, K., Millar, A.J.W. (2023). Pediatric Liver Transplantation. In: Puri, P., Höllwarth, M.E. (eds) Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-81488-5_87
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DOI: https://doi.org/10.1007/978-3-030-81488-5_87
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